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open access

IRES Track II - Cape Horn ASIs: Climate change and disease ecology at the southern end of the Americas

Description: Research giving students the opportunity to be trained in quantitative experimental design and work as part of a multinational research collaboration to study infectious disease emergence in one of the few remaining pristine places on Earth. The Cape Horn Biosphere Reserve (CHBR) off the southern tip of South America protects pristine ecosystem is perfect for this type of graduate student training.
Date: 2021-09-01/2021-08-31
Creator: Gregory, Andrew; Kennedy, James H. & Rozzi, Ricardo, 1960-
Partner: UNT College of Science
open access

Fatty Acid Amide Hydrolases and Chemical Communication in Plants

Description: Research seeking to understand how an evolutionarily-conserved group of plant enzymes utilizes chemical signals to regulate growth and to influence their microbial environment. Specific research aims include the discovery of new enzymes and their substrate molecules that act as communication signals. Broader applications of this research may offer new strategies to enhance agricultural outputs by manipulating plant-microbe interactions in crop and soil systems.
Date: 2021-07-01/2024-06-30
Creator: Chapman, Kent Dean; Aziz, Mina & Blancaflor, Elison B.
Partner: UNT College of Science
open access

Non-Genetic Inheritance of Hypoxia Tolerance in Fishes: Dynamics and Mechanisms

Description: Research quantifying the inheritance of tolerance to low oxygen in a model fish and then determine the tolerance mechanisms, at organismal to molecular levels, that are passed on from parents to their offspring. The investigators will not only focus on conventional, well-studied genetic mechanisms for inheritance, but will explore so-called “epigenetic” forms of inheritance that may transfer parental characteristics for only a generation or two. Such “temporary inheritance” might actually require less energy and be more beneficial to a species than the more permanent form of genetic inheritance.
Date: 2021-06-15/2025-05-31
Creator: Burggren, Warren W. & Padilla, Pamela A.
Partner: UNT College of Science
open access

G-RISE at the University of North Texas

Description: The University of North Texas (UNT) serves over 32,000 undergraduate and 7,000 graduate students of which 50% of the undergraduate population and 20% of the graduate population are underrepresented minority (URM). UNT is ranked by the Carnegie Classification as a Tier 1 institute, is a Hispanic Serving Institute, and is dedicated to providing quality mentoring to a diverse group of Ph.D. students. The UNT G-­RISE mission is to provide a biomedical Ph.D. training program that is inclusive, culturally responsive, increases diversity, enhances scientific skill sets, develops trainee career and professional skill sets, provides opportunities to participants, and increases faculty development as a mentor.
Date: 2021-05-01/2022-04-30
Creator: Padilla, Pamela A.; Burggren, Warren W.; Cisneros, Gerardo Andrés & Hughes, Lee E.
Partner: UNT College of Science
open access

NSFDEB-NERC: Collaborative Research: Wildlife corridors: do they work and who benefits?

Description: Research on the impact of wildlife corridors using genetics as the measure of effectiveness. The study will use 20 independent landscapes to quantify how corridor traits affect gene flow, and will use non-flying mammals as focal species because they are strongly affected by fragmentation. The research team hypothesizes (1) a strong non-linear decline in success (gene flow) with corridor length, reflecting the skewed distribution of dispersal distances within species; (2) success will drop steeply as corridor width falls below a threshold, with the threshold determined by species traits; and (3) species that are bigger, are habitat specialists, or have greater dispersal abilities (relative to brain size or reproductive rate) will benefit more from corridors. Testing these hypotheses will allow generalization to a wide range of mammal species not included in this project. We will use highly flexible Random Forest models to answer the overarching question: What landscape traits (e.g., corridor width, degree of human disturbance) and species traits (mobility, affinity to particular land cover types) are associated with effective corridors?
Date: 2021-01-15/2023-12-31
Creator: Gregory, Andrew
Partner: UNT College of Science
captions transcript

How Tiny Zebrafish and Their Surprisingly Human-Like Genome Can Benefit Medical Research

Description: Presentation highlighting the use of zebrafish to identify genes relating to predisposition to thromboembolism and cardiovascular disease in people with African ancestry. It was presented at the UNT Transdisciplinary Conference on Ancestral Genomics Research which was held virtually on November 20-21, 2020.
Date: November 21, 2020
Duration: 16 minutes 54 seconds
Creator: Jagadeeswaran, Pudur
Partner: University of North Texas
open access

Impact of Nutrient Intake on Hydration Biomarkers Following Exercise and Rehydration Using a Clustering-Based Approach

Description: This article investigates the impact of nutrient intake on hydration biomarkers in cyclists before and after a 161 km ride, including one hour after a 650 mL water bolus consumed post-ride. Most predictor groups showed significant association with at least one hydration biomarker: (1) Glycemic Load + Carbohydrates + Sodium, (2) Protein + Fat + Zinc, (3) Magnesium + Calcium, (4) Pinitol, (5) Caffeine, (6) Fiber + Betaine, and (7) Water; potassium + three polyols, and mannitol + sorbitol showed no significant associations with any hydration biomarker. The authors conclude that in a real-life scenario, some nutrients may serve as mediators of body water, and urine-specific hydration biomarkers may be more responsive to nutrient intake than measures derived from plasma or body mass.
Date: April 30, 2020
Creator: Muñoz, Colleen X.; Johnson, Evan C.; Kunces, Laura J.; McKenzie, Amy L.; Wininger, Michael; Butts, Cory L. et al.
Partner: UNT College of Education
open access

Underlying Ossification Phenotype in a Murine Model of Metastatic Synovial Sarcoma

Description: This article presents the analysis of genetic mouse models of synovial sarcoma to determine the extent of ossification in the tumors and its relationship with morbidity. The authors noted higher ossification within their metastatic mouse model of synovial sarcoma. Their conclusion is that both metastasis and ossification are dependent on time, but that they are independent of one another.
Date: April 10, 2020
Creator: Kirkham, Matthew; Kalivas, Austen; Fatema, Kaniz; Luelling, Sarah; Dubansky, Brooke H.; Dubansky, Benjamin et al.
Partner: UNT College of Science
open access

Improved Yield and Photosynthate Partitioning in AVP1 Expressing Wheat (Triticum aestivum) Plants

Description: Article presents data consistent with the positive effect that the expression of the Arabidopsis thaliana H+-PPase (AVP1) has on reduced carbon partitioning and yield increases in wheat.
Date: March 17, 2020
Creator: Regmi, Kamesh C.; Yogendra, Kalenahalli; Gomes Farias, Júlia; Li, Lin; Kandel, Raju; Yadav, Umesh P. et al.
Partner: UNT College of Science
open access

Brassinosteroids Inhibit Autotropic Root Straightening by Modifying Filamentous-Actin Organization and Dynamics

Description: Article describes study testing the hypothesis that epi-brassinolide (eBL) might enhance root gravitropism through its effects on filamentous-actin (F-actin) in plants.
Date: February 4, 2020
Creator: Bang, Louise de; Paez-Garcia, Ana; Cannon, Ashley E.; Chin, Sabrina; Kolape, Jaydeep; Liao, Fuqi et al.
Partner: UNT College of Science
open access

Prioritizing riparian corridors for ecosystem restoration in urbanizing watersheds

Description: This article explores restoration, rather than protection, being the basis for developing a watershed level strategy for improving water quality in urbanizing watersheds.This study uses a geographical information system (GIS) approach that utilizes riparian characteristics extracted from 40-meter wide corridors centered on streams and rivers. The model was applied to 90 sub-watersheds in the watershed of an important drinking water reservoir in north central Texas, USA.
Date: February 4, 2020
Creator: Atkinson, Samuel F. & Lake, Matthew C.
Partner: UNT College of Science
open access

Sub-Antarctic Freshwater Invertebrate Thermal Tolerances: An Assessment of Critical Thermal Limits and Behavioral Responses

Description: Describes study which assessed the upper (CTmax) and lower (CTmin) thermal limits of three freshwater macroinvertebrate taxa with restricted low elevation distribution (20 m a.s.l.) and three taxa restricted to upper elevations (480 and 700 m a.s.l.) in the Magellanic sub-Antarctic ecoregion of southern Chile, and argues that their low tolerance to temperature increase can make them useful as indicators of thermal alteration in their habitats.
Date: February 4, 2020
Creator: Rendoll-Cárcamo, Javier; Contador, Tamara; Convey, Peter & Kennedy, James H.
Partner: UNT College of Science
open access

A Small Compound Targeting Prohibitin with Potential Interest for Cognitive Deficit Rescue in Aging mice and Tau Pathology Treatment

Description: Article describes study analyzing the effects of a new purine derivative drug, PDD005, in attenuating mechanisms involved in the pathogenesis of neurodegenerative diseases, using both in vivo and in vitro models.
Date: January 24, 2020
Creator: Guyot, Anne-Cécile; Leuxe, Charlotte; Disdier, Clémence; Oumata, Nassima; Costa, Narciso; Le Roux, Gwenaëlle et al.
Partner: UNT College of Science
open access

ARABIDOPSIS DEHISCENCE ZONE POLYGALACTURONASE 1 (ADPG1) releases latent defense signals in stems with reduced lignin content

Description: Article highlights the importance of pectin in cell wall integrity and the value of lignin modification as a tool to interrogate the informational content of plant cell walls.
Date: January 23, 2020
Creator: Gallego-Giraldo, Lina; Liu, Chang; Pose-Albacete, Sara; Pattathil, Sivakumar; Peralta, Angelo Gabriel; Young, Jenna et al.
Partner: UNT College of Science
open access

Phenotypic Switching Resulting From Developmental Plasticity: Fixed or Reversible?

Description: Article explores the question of whether animals with switched phenotypes during early development are unable to return to a normal range of adult phenotypes, or whether they do not experience the specific environmental conditions necessary for them to switch back to the normal range of adult phenotypes.
Date: January 21, 2020
Creator: Burggren, Warren W.
Partner: UNT College of Science
open access

Multifeature analyses of vascular cambial cells reveal longevity mechanisms in old Ginkgo biloba trees

Description: This article investigates age-related changes in Ginkgo biloba trees to learn more about the molecular and metabolic mechanisms underlying their longevity. The results revealed that long-lived trees have evolved compensatory mechanisms to maintain a balance between growth and aging processes.
Date: January 13, 2020
Creator: Wang, Li; Cui, Jiawen; Jin, Biao; Zhao, Jiangou; Xu, Huimin; Lu, Zhaogeng et al.
Partner: UNT College of Science
open access

Liquid Chromatography Tandem Mass Spectrometry Quantification of ¹³C-Labeling in Sugars

Description: This article describes a new methodology for monitoring sucrose labeling using liquid chromatography tandem mass spectrometry (LC-MS/MS). To date, the most commonly used method to monitor sucrose labeling is by nuclear magnetic resonance, which requires substantial amounts of biological sample.
Date: January 10, 2020
Creator: Cocuron, Jean-Christophe; Ross, Zacchary & Alonso, Ana P.
Partner: UNT College of Science
open access

Hypoxic level and duration differentially affect embryonic organ system development of the chicken (Gallus gallus)

Description: This article investigates how key organ systems are affected by hypoxia. The results indicated that either modest hypoxia (15% O2) throughout development, or hypoxia at any level during the late stages (d 11 to 18), increased the heart and chorioallantoic membrane weight, which partly compensated for the detrimental effects of hypoxia on embryonic development.
Date: December 11, 2019
Creator: Zhang, H. & Burggren, Warren W.
Partner: UNT College of Science
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