Knockdown of zebrafish tmem242 enhances the production of ROS that signals to increase f9a expression resulting in DIC-like condition
Description:
Article investigates the role of the transmembrane protein TMEM242 in hemostasis using zebrafish thrombocytes and gene knockdown experiments. The findings show that TMEM242 depletion increases bleeding and reactive oxygen species levels, disrupts coagulation and fibrin formation, and alters clotting factor gene expression, suggesting a mechanism involving impaired ATP synthase, ROS signaling, and upregulation of SIRT6 and NRF2.
Date:
January 24, 2025
Creator:
Deebani, Afnan; Mary, Jabila; Dhinoja, Sanchi; Al Qaryoute, Ayah; Fallatah, Weam & Jagadeeswaran, Pudur
Partner:
UNT College of Science