Brain Delivery of Thyrotropin-Releasing Hormone via a Novel Prodrug Approach
Description:
Using thyrotropin-releasing hormone (TRH) as a model, paper explores whether synergistic combination of lipoamino acid(s) and a linker cleaved by prolyl oligopeptidase (POP) can be used as a promoiety for prodrug design for the preferential brain delivery of the peptide.
Date:
July 18, 2019
Creator:
Prokai-Tatrai, Katalin; De La Cruz, Daniel L.; Nguyen, Vien; Ross, Benjamin P.; Toth, Istvan & Prókai, László, 1958-
Item Type:
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Partner:
UNT Health Science Center