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Description of Facilities and Mechanical Components: Medical Research Reactor (MRR)

Description: Report issued by the Brookhaven National Laboratory discussing the Medical Research Reactor at the Medical Research Center. Design, tests, and operations of the reactor are presented. This report includes tables, illustrations, and photographs.
Date: February 1960
Creator: Godel, Jules B.
Partner: UNT Libraries Government Documents Department
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Chemonuclear Processing

Description: Technical report giving an overview of the use of nuclear energy to produce chemicals including a rough estimate of the economic potential.
Date: February 1962
Creator: Steinberg, Meyer, 1924-
Partner: UNT Libraries Government Documents Department
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Efficiency pf Multiple Traversal Targets

Description: The efficiency of multiple traversal targets is defined as the probability that a proton dies by making a nuclear collision in the target rather than by hitting the limit of the synchrotron aperture. The efficiencies of Be, Al, Cu, and Pb targets are shown for 15 and 30-Bev protons in the Brooknaven AGS. Beryllium was found to be the most efficient. (M.C.G.)
Date: February 5, 1962
Creator: Courant, E.D.
Partner: UNT Libraries Government Documents Department
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Metabolism of C¹⁴-Carboxyl-Labeled-3-Hydroxyanthranilic Acid in Normal and Neoplastic Mice

Description: The o-aminophenol, 3-hydroxyanthranilic acid (3-OHAA) is a metabolite of tryptophan normally present in urine in trace quantities. C14-3-OHAA was given to normal mice and mice with either mammary adenocarcinoma, glioblastoma multiforme or ascites tumor to study the influence of these transplantable tumors on metabolism of 3-OHAA.
Date: February 16, 1962
Creator: Hankes, Lawrence Valentine; Schmaeler, Max & Stoner, Richard D.
Partner: UNT Libraries Government Documents Department
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Eddy Transport in Liquid-Metal Heat Transfer

Description: This report seeks to "develop a practical method of evaluating the eddy diffusivity of heat transfer for liquid metals, so that it can be incorporated into the more or less standard theoretical methods to give heat transfer coefficients which are in reasonable agreement with experimental facts"--from introduction.
Date: February 18, 1962
Creator: Dwyer, Orrington Embry, 1912-
Partner: UNT Libraries Government Documents Department
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Abscopal Effects of Localized Irradiation by Accelerator Beams

Description: The aim of this series of experiments was to evaluate the existence of abscopal effects of irradiation. No attempt was made towards the elucidation of mechanisms. Very early in the history of radiological research it was noticed radiation produces both local and general effects involving the entire body. Gauss and Lembcke introduced the term "Roentgenkater" (radiation sickness). They ascribed these "General Effects" to the circulation of toxic substances released from cells that disintegrated f… more
Date: February 1, 1963
Creator: Jansen, C. R.; Bond, V. P.; Rai, K. R. & Lippincott, S. W.
Partner: UNT Libraries Government Documents Department
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The Calculation of Zero-Point Energies of Molecules by Perturbation Methods

Description: Two methods are proposed for calculating zero-point energies of molecules. The first makes use of the fact that one can easily write down the quantum mechanical Hamiltonian for a vibration system. The zero-point energy can then be obtained by a perturbation scheme without solving the secular equation. The second method requires a knowledge of the normal modes and frequencies of a reference molecule, but then enables one to calculate isotope effects by a perturbation scheme. The methods are appl… more
Date: February 1963
Creator: Wolfsberg, Max
Partner: UNT Libraries Government Documents Department
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Chronic Excess Salt Consumption as an Etiologic Factor in Human Hypertension

Description: Since 1940 it has been known that extra salt (i.e. sodium chloride) facilitated the development of experimental hypertension induced by various sterols; subsequently hypertension was induced by desoxycorticosterone acetate plus sodium chloride; then hypertension was produced by using hypertonic saline as the sole source of liquid; and finally, in 1953, Menesly and his associates reported that chronic ingestion of excess dietary salt alone would produce hypertension in rats. Furthermore, in conf… more
Date: February 1, 1963
Creator: Dahl, Lewis K.
Partner: UNT Libraries Government Documents Department
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Di-Interstitial Annealing During the First Neutron Irradiation of Graphite: The Mobility of C2

Description: Radiation and annealing mechanisms for dimensional and c-axis changes in which the di-interstitial can be mobile at any or all temperatures above absolute zero are shown to be concordant with earlier work used to determine the migration energy energy of single interstitials and the absolute rate of displacing atoms in graphite. The mechanisms account for the stability of c-axis and dimensional changes with time in the absence of irradiation and with observed c-axis annealing at room temperature… more
Date: February 1, 1963
Creator: Schweitzer, Donals G.
Partner: UNT Libraries Government Documents Department
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The Effects of 250-kv X-Ray on the Dog's Pancreas: Morphological and Functional Changes

Description: Previous investigations that the pancreas is a radioresistant organ. Ivy in 1924 noted the presence of a fibrotic atrophic pancreas in a dog which had received one erythema dose to the epigastrium. Fisher in 1923 reported that four to five erythema doses delivered in a single application caused complete disappearance of the irradiated pancreatic remnant in about two months. These dogs died because of uncontrolled diabetes. One dog that received four erythema doses (possibly 200 r) was sacrifice… more
Date: February 1, 1963
Creator: Archamefau, John; Griem, Melvin & Harper, Paul
Partner: UNT Libraries Government Documents Department
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The Effects of Chronic Gamma Irradiation on the Growth of Kalanchoe cv. "Brilliant Star"

Description: Kalanchoe seedlings were exposed to 330 r/20 hrs/day from a Co60 source. Samples were harvested weekly. No new leaves were produced after initial exposure to irradiation. Mitosis in the apical meristem appears to have been suppressed. However, the axillary meristem and the cambium continue their activity. This results in a much broadened stem tip with enlarged cells, supported by a stout internode in which cell size has remained relatively normal but cell number has increased. After about 26 da… more
Date: February 1, 1963
Creator: Stein, O. L. & Sparrow, A. H.
Partner: UNT Libraries Government Documents Department
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The Effects of Radiations of Different let on Early Responses in the Mammal

Description: This paper will first note briefly the place and status of radiobiotopical investigations with fast neutrons. The monoenergetic (fast) neutron technique employed at this laboratory will be then described and results of studies with various criteria-of-effect in the mouse will be reviewed. Finally, certain general patterns of response for these systems will be pointed out as functions of neutron energy.
Date: February 1, 1963
Creator: Bateman, J. L. & Bond, V. P.
Partner: UNT Libraries Government Documents Department
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Effects of Trichinella Spiralis Infection on Incorporation of Amino Acids into Serum and Hemoglobin

Description: Encysted Trichinella spiralis larvae incorporated carbon-14 from mice fed diets containing C14 -labeled glycerine and DL-alanine. In general, a higher level of C14 activity (C14 per gram of dry tissue) was found in muscle larvae than in muscle tissue. The presence of encysted Trichinella larvae in the muscles of 56-day and 180-day infected mice did not alter incorporation of C14 from these amino acids into infected muscle protein when compared with noninfected muscle. These experiments were ext… more
Date: February 1, 1963
Creator: Hankes, Lawrence V. & Stone, Richard D.
Partner: UNT Libraries Government Documents Department
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Elimination of Phases the Life Cycle of Leukemic Cells From in Vivo Labeling in Human Beings With Tritiated Thymidine

Description: Our earlier in vitro studies have suggested that malignant tumors may not produce new cells more rapidly than normal cells are produced in the "steady state" equilibrium. Obviously tumors of all typed represent a diversion from "steady state" production with a net gain in mass of tissue. However, the increase in mass is not necessarily constant and may fluctuate in the natural history of the disorder. DNA labeling with tritiated thymidine had made it possible to characterize normal "steady stat… more
Date: February 1, 1963
Creator: Killmann, S. A.; Cronkite, E. P.; Robertson, J. S.; Fliedner, T. M. & Bond, V. P.
Partner: UNT Libraries Government Documents Department
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The Fate of Transfused H3 Thymidine Labeled Bone Marrow Cells in Irradiated Recipients

Description: It has been established by chromosome marker studies, histochemical, immunological, and cytological methods that the hemopoietic tissues of animals exposed to lethal doses of whole-body irradiation can be repopulated by transfused autologous, homologous or heterologous bone marrow cells. However, the morphology of the cell responsible for the regeneration of hematopoietic activity in the various hemopoietic organs has not been identified. It has been shown that the bone marrow contains the cell… more
Date: February 1, 1963
Creator: Fliedner, T. M.; Thomas, E. D.; Meyer, L. M. & Cronkite, E. P.
Partner: UNT Libraries Government Documents Department
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The Function of Bridging Groups in Electron-Transfer Reactions

Description: Electron-transfer reactions involving bridged transition states are examined from the point of view of adiabatic electron transfer theory. One important function of the bridging group is to decrease the effective dipole moment of the charge system of the reaction ions. The effect on the activation energy is different for outer-sphere and inner-sphere reactions. Trends in the halide and hydroxide catalysis of isotopic exchange reactions of transition metal ions are discussed.
Date: February 1, 1963
Creator: Hush, N. S.
Partner: UNT Libraries Government Documents Department
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Fundamental Problem of Late Neurological EffectFollowing Acute Irradiation

Description: Since the end of the last century (Tarknow, 1896) radiation effect o the nervous tissue has been studied in experimental animals and humans by numerous investigators, using mostly pathomorphological changes as a parameter of radiosensitivity . With increasing time intervals following radiation, pathomorphological changes are more evident, which has been known for quite some time.
Date: February 1, 1963
Creator: Yamamoto, Y. L.
Partner: UNT Libraries Government Documents Department
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Indirect Effect of X-Radiation on Bone Growth in Rats

Description: It has been known for many years that bone growth may be retarded by relatively large doses of therapeutic radiation. Similar doses of radiation have also shown retarded growth in animals. More recently, reports of studies of Japanese children exposed to the Atomic Bomb Detentions at Hiroshima and Nagasaki and Marshallese children exposed to radiation in the fallout accident of 1954 have indicated some impairment in their growth and development, possibly related to radiation exposure. Since the… more
Date: February 1, 1963
Creator: Conard, R. A.
Partner: UNT Libraries Government Documents Department
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Inelastic Interactions of 11.4 Bec/c π" Mesons in Hydrogen

Description: Production cross sections and angular distributions of Λ and K° particles produced by 11.4 Bev/c π" mesons in hydrogen have been measured. A systematic investigation was made of all two-body decays of unstable neutral particles. No events inconsistent with γ, Λ, or K° were found. Production cross sections, angular distributions and effective mass distributions of π mesons produced in 4-prong events were also measured. No evidence for dominance of any high mass multi-pion resonance was found. Bo… more
Date: February 1, 1963
Creator: Ferbel, T. & Taft, H.
Partner: UNT Libraries Government Documents Department
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Lysogeny in Rhizobium Leguminosarum and R. Trifolii

Description: Seven lysogenic strains - three of Rhizobium Leguminosarum and four of R-trifolii - were identified among a total of 54 strains from these two species and R. phascoli. The R. leguminosarum strain may be multiply lysogenic; two of them also produce lethal agents resembling bacteriocins in their effects. Lysogeny was confirmed by standard criteria of UV-inducibility, self-immunity, and reproductive ability. Lysogenic conversion involving symbiotic characteristics was not observed. A minimum of s… more
Date: February 1, 1963
Creator: Schwinghamer, E. A. & Reinhardt, D. J.
Partner: UNT Libraries Government Documents Department
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The Microbeam as a Tool in Radiobiology

Description: In the analysis of the effect of ionizing radiation on living systems, the problem is complicated by the interaction of one part of the system with other parts. If an entire mouse is subjected to radiation, only a few of the most radiosensitive organs, the "weak links," react to the insult and essentially limit the size of the dose delivered since there is little to be learned from irradiating a dead mouse. Thus an insensitive organ like muscle will not respond at all to a total body dose. Like… more
Date: February 1, 1963
Creator: Curtis, Howard J.
Partner: UNT Libraries Government Documents Department
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Mitotic Indices of Human Bone Marrow Cells. Duration of Some Phases of Erythrocytic and Granulocytic Proliferation Computed From Mitotic Indices

Description: Data on the mitotic indices of human bone marrow cells were reported in the first paper of this series, and theoretical considerations on the applicability and limitations of the index in determining kinetic parameters were discussed. In the present paper an attempt is made to compute time parameters of normal bone marrow cell proliferation from the data presented in the first paper.
Date: February 1, 1963
Creator: Killmann, S. A.; Cronkite, E. P.; Fliedner, T. M. & Bond, V. P.
Partner: UNT Libraries Government Documents Department
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Possibilities and Limitations in the use of Tritiated Thymidine for in Vivo Cytokinetic Studies on Lymphoreticular Tissue

Description: Tritiated thymidine (H3TDR), a specific precursor of deoxyribonucleic acid (DNA), has proved to be a valuable tool in the study of in vivo cellular kinetics. Various methods of analysis have been used in autoradiographic investigations of proliferative patterns and time parameters in different cell lines.
Date: February 1, 1963
Creator: Cottier, H.; Odartchenko, N.; Feinendegen, L. E. & Bond, V. P.
Partner: UNT Libraries Government Documents Department
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