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The History of the Brookhaven Biology Department Mouse Colony No. 1 (Swiss-Bridge-Bagg-O'Grady-Walter Reed Strain) With Endemic Occult Cerebral Encephalitozoönosis and Colony No. 2

Description: Innes, Zemen, Frenkel, Borner and Wright (1962) described an outbreak of encephalitozoönosis of the central nervous system in mice, a summary of which is given below for an understanding of why this appendix may be of interest. When the paper was presented for publication, the editors of the journal decided to omit the history of our mouse colony. In our opinion, to understand (a) how this infection may have arisen and (b) may have spread, and still exist in some colonies, it is of prime import… more
Date: February 25, 1963
Creator: Innes, J. R. M. & Borner, G
Partner: UNT Libraries Government Documents Department
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Mode Identification in the Iris-Loaded Waveguide of a RF Particle Separator

Description: The theoretical and practical aspects of the accelerating mode (TM01) in iris-loaded waveguides have been covered extensively in many reports and publications. The pulse shortening observed in linacs and the possible application of an iris-loaded waveguides as the deflecting structure for rf particle separators stimulated the interest in the nature of higher order modes. Some experimental results on higher order modes in iris-loaded waveguides are available in references. Results of studies don… more
Date: February 18, 1963
Creator: Hahn, H. & Halama, H. J.
Partner: UNT Libraries Government Documents Department
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Wave Functions for Quadrupole Antishielding Factors

Description: The purpose of this paper is to present tables of the perturbed wave functions which have been recently obtained in a calculation of the quadruple antishielding factors γ∞ for the Mn+2, Fe+3, Ga+3, and Ag+ ions. The wave functions v'1(nℓ-ℓ) which are tabulated represent the effect of the perturbation due to a nuclear quadruple moment Q on the wave functions of the outermost electrons of the ion core.
Date: February 25, 1963
Creator: Sternheimer, R. M.
Partner: UNT Libraries Government Documents Department
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Studies of the Rapid Beam Ejector at the Cosmotron

Description: For an experiment to measure the magnetic moment of the Λ hyperon, it was necessary to extract the external beam of the Cosmotron with maximum efficiency and with minimum time duration. To accomplish this end, the standard external beam of the machine was supplemented with the Rapid Beam Ejector. It was found that, unfortunately, the ejection efficiency of the beam was less than normal when the RBE was used. Measurements of the ejection efficiency were made by irradiating polyethylene foils at … more
Date: February 7, 1963
Creator: Barton, M. Q.
Partner: UNT Libraries Government Documents Department
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Fluorimetric Assay of α-Chymotrypsin

Description: The enzymolysis by α-chymotrypsin of the substrates, N-acetyl-L-tryptophane ethyl ester and N-acetyl-L-tyrosine ethyl ester, was followed by means of fluorescence whose intensity increased fourfold and threefold per mole respectively as substrate was transformed into amino acid. The assay by fluorescence was several orders of magnitude more sensitive than the assay by differential absorption spectra of these substances and was in agreement with it in those concentration regions where both metho… more
Date: February 25, 1963
Creator: Bielski, Benon H. J. & Freed, Simon
Partner: UNT Libraries Government Documents Department
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An Isochronal Differential Microcalorimeter

Description: An isochronal differential-type microcalorimeter has been designed and constructed. As a result of its simple design it is very easy to handle the samples and assemble the calorimeter. Important to the operation of the calorimeter is a program, also working on the differential principle, that provides linear temperature rise of the samples. This calorimeter is used to measure very small energy releases such as those found in precipitation, stored energy, etc. It is demonstrated that the calorim… more
Date: February 25, 1963
Creator: Arndt, R. A. & Fujita, F. E.
Partner: UNT Libraries Government Documents Department
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A Re-Analysis of Short-Range Order in Cu3Au

Description: Cowley's measurements of the short-range order parameters, αi, in Cu3Au at T=405°C have been re-evaluated taking into account the effects of thermal vibrations and static displacements due to differing atomic sizes. The separate corrections for the thermal vibrations and the first-neighbor atomic size factor are found to be quite large, demonstrating their importance in the usual experiments. When combined, the corrections in this case largely cancel, and only the values of α1 and α3 are apprec… more
Date: February 25, 1963
Creator: Walker, C. B. & Keating, D. T.
Partner: UNT Libraries Government Documents Department
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Antibody Formation by Transplanted Bone Marrow, Spleen, Lymph Node and Thymus Cells in Irradiated Recipients

Description: The role of the marrow as a site for antibody formation has been considered for many years. In 1912 Ludke reported the appearance of antibody in cultures of marrow cells obtained from previously immunized rabbits. Specific agglutinins for killed typhoid bacilli and lysins for ox red cells and sheep red cells were detected in the culture media 2 to 5 days later. However, the cultured cells failed to produce antibody when these antigens were added to the media. Similar findings by Reiter, Przygod… more
Date: February 25, 1963
Creator: Stoner, Richard D. & Bond, Victor P.
Partner: UNT Libraries Government Documents Department
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Bromine Exchange in Graphite-Bromine Lamellar Compounds

Description: A kinetic study of the exchange of normal and radioactive bromine in graphite-bromine lamellar compounds has been made at temperatures of 30° to 50°C. Natural and synthetic graphite powders were investigated. Two alternative mechanisms for the exchange, volume diffusion and surface exchange, were considered. The data were in better agreement with the diffusion mechanism. Diffusion coefficients of 10 -9 to 10 -8 cm2/sec and an activation energy of 11 to 14 kcal/mole were calculated for the natur… more
Date: February 25, 1963
Creator: Aronson, Seymour
Partner: UNT Libraries Government Documents Department
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Crystal Structure of a Sodium Cobalt Molybdate

Description: The cobalt and molybdenum positions had been derived from a three-dimensional Patterson function based on complete data out to λ-1 sin θMo≈ 1. From the separation of the separation of the Mo atoms it was thought that the structure contained free, unlinked MoO4 -2 ions, and this, together with the observed density and analyses for Co and Mo, suggested that the composition was probably Co2(MoO4)3. The paucity of structural information on complex oxide systems and the interesting properties, both … more
Date: February 25, 1963
Creator: Ibers, James A. & Smith, G. W.
Partner: UNT Libraries Government Documents Department
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Electric Currents, Membranes, and Biological Sources of Electromotive Force

Description: The analysis of closed circuit systems in which spontaneous steady-state electric currents appear can be carried out with the use of the function [function not transcribed]. The analysis indicates that any open circuit system of the form. Phase 1, barrier 1, phase 2, ......, phase b, barrier b, phase 1' is a chemical source of electromotive force when the phase 1 and 1' are identical, when the system contains two or more barriers whose sets of ionic transport members are different, and when the… more
Date: February 25, 1963
Creator: Nims, Leslie F.
Partner: UNT Libraries Government Documents Department
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The Microbeam as a Tool in Radiobiology

Description: In the analysis of the effect of ionizing radiation on living systems, the problem is complicated by the interaction of one part of the system with other parts. If an entire mouse is subjected to radiation, only a few of the most radiosensitive organs, the "weak links," react to the insult and essentially limit the size of the dose delivered since there is little to be learned from irradiating a dead mouse. Thus an insensitive organ like muscle will not respond at all to a total body dose. Like… more
Date: February 1, 1963
Creator: Curtis, Howard J.
Partner: UNT Libraries Government Documents Department
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Mitotic Indices of Human Bone Marrow Cells. Duration of Some Phases of Erythrocytic and Granulocytic Proliferation Computed From Mitotic Indices

Description: Data on the mitotic indices of human bone marrow cells were reported in the first paper of this series, and theoretical considerations on the applicability and limitations of the index in determining kinetic parameters were discussed. In the present paper an attempt is made to compute time parameters of normal bone marrow cell proliferation from the data presented in the first paper.
Date: February 1, 1963
Creator: Killmann, S. A.; Cronkite, E. P.; Fliedner, T. M. & Bond, V. P.
Partner: UNT Libraries Government Documents Department
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The Effects of 250-kv X-Ray on the Dog's Pancreas: Morphological and Functional Changes

Description: Previous investigations that the pancreas is a radioresistant organ. Ivy in 1924 noted the presence of a fibrotic atrophic pancreas in a dog which had received one erythema dose to the epigastrium. Fisher in 1923 reported that four to five erythema doses delivered in a single application caused complete disappearance of the irradiated pancreatic remnant in about two months. These dogs died because of uncontrolled diabetes. One dog that received four erythema doses (possibly 200 r) was sacrifice… more
Date: February 1, 1963
Creator: Archamefau, John; Griem, Melvin & Harper, Paul
Partner: UNT Libraries Government Documents Department
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Elimination of Phases the Life Cycle of Leukemic Cells From in Vivo Labeling in Human Beings With Tritiated Thymidine

Description: Our earlier in vitro studies have suggested that malignant tumors may not produce new cells more rapidly than normal cells are produced in the "steady state" equilibrium. Obviously tumors of all typed represent a diversion from "steady state" production with a net gain in mass of tissue. However, the increase in mass is not necessarily constant and may fluctuate in the natural history of the disorder. DNA labeling with tritiated thymidine had made it possible to characterize normal "steady stat… more
Date: February 1, 1963
Creator: Killmann, S. A.; Cronkite, E. P.; Robertson, J. S.; Fliedner, T. M. & Bond, V. P.
Partner: UNT Libraries Government Documents Department
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Radiation Effect on the RNA Metabolism of the Central Nervous System

Description: Numerous studies on the effects of radiation on the central nervous system used traditional pathomorphological changes as parameters of radiosensitivity, but pathogenesis and mechanisms of radiation injury to the nervous tissue are still little understood. Furthermore, the great discrepancy of dose requirement leading to physiological responses and on the other hand to pathomorphological changes in the central nervous system is not satisfactorily explained.
Date: February 1, 1963
Creator: Yamamoto, Y. L.; Feinendegen, L. E. & Bond, V. P.
Partner: UNT Libraries Government Documents Department
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Indirect Effect of X-Radiation on Bone Growth in Rats

Description: It has been known for many years that bone growth may be retarded by relatively large doses of therapeutic radiation. Similar doses of radiation have also shown retarded growth in animals. More recently, reports of studies of Japanese children exposed to the Atomic Bomb Detentions at Hiroshima and Nagasaki and Marshallese children exposed to radiation in the fallout accident of 1954 have indicated some impairment in their growth and development, possibly related to radiation exposure. Since the… more
Date: February 1, 1963
Creator: Conard, R. A.
Partner: UNT Libraries Government Documents Department
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Effects of Trichinella Spiralis Infection on Incorporation of Amino Acids into Serum and Hemoglobin

Description: Encysted Trichinella spiralis larvae incorporated carbon-14 from mice fed diets containing C14 -labeled glycerine and DL-alanine. In general, a higher level of C14 activity (C14 per gram of dry tissue) was found in muscle larvae than in muscle tissue. The presence of encysted Trichinella larvae in the muscles of 56-day and 180-day infected mice did not alter incorporation of C14 from these amino acids into infected muscle protein when compared with noninfected muscle. These experiments were ext… more
Date: February 1, 1963
Creator: Hankes, Lawrence V. & Stone, Richard D.
Partner: UNT Libraries Government Documents Department
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Lysogeny in Rhizobium Leguminosarum and R. Trifolii

Description: Seven lysogenic strains - three of Rhizobium Leguminosarum and four of R-trifolii - were identified among a total of 54 strains from these two species and R. phascoli. The R. leguminosarum strain may be multiply lysogenic; two of them also produce lethal agents resembling bacteriocins in their effects. Lysogeny was confirmed by standard criteria of UV-inducibility, self-immunity, and reproductive ability. Lysogenic conversion involving symbiotic characteristics was not observed. A minimum of s… more
Date: February 1, 1963
Creator: Schwinghamer, E. A. & Reinhardt, D. J.
Partner: UNT Libraries Government Documents Department
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Thermodynamics of Fused Salt Mixtures From EMF Measurements. The Systems NaCl-KCl, NaCl-MgCl2, and NaCl-CeCl3.

Description: The following cells were operated at 820°C: [equations not transcribed] where the over-all reaction in each cell is simply the transfer of NaCl from pure NaCl to the mixtures of the right hand compartment. The porcelain acts as a pure sodium ion conductor in these cells. The relative partial molar free energy of mixing for sodium chloride, FMNaCl, is given by [equation not transcribed] where E is the EMF of the cell. Results are given over the entire composition range in each system and compare… more
Date: February 1, 1963
Creator: Egan, James J. & Bracker, John
Partner: UNT Libraries Government Documents Department
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Tissue Distribution and Storage Forms of Vitamin B12 Injected and Orally Administered to the Dog

Description: Previous attempts by the present authors to compare the behavior of orally administered vitamin B12 with that of injected material have been inconclusive. Thus, 30 days after administration to normal humans, 0.19% of a tracer amount (0.5 μg) of injected radioactive vitamin B12 is excreted per day; and in an independent study, the eventual daily output was found to be 0.23% of a 3 μg dose. By contrast the total excretion rate of normal vitamin B12 from body stores appears to be only ≈0.03% per d… more
Date: February 1, 1963
Creator: Rosenblum, Charles; Reizenstein, Peter G.; Cronicite, Eugene P. & Meriwether, Henry T.
Partner: UNT Libraries Government Documents Department
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Abscopal Effects of Localized Irradiation by Accelerator Beams

Description: The aim of this series of experiments was to evaluate the existence of abscopal effects of irradiation. No attempt was made towards the elucidation of mechanisms. Very early in the history of radiological research it was noticed radiation produces both local and general effects involving the entire body. Gauss and Lembcke introduced the term "Roentgenkater" (radiation sickness). They ascribed these "General Effects" to the circulation of toxic substances released from cells that disintegrated f… more
Date: February 1, 1963
Creator: Jansen, C. R.; Bond, V. P.; Rai, K. R. & Lippincott, S. W.
Partner: UNT Libraries Government Documents Department
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The Fate of Transfused H3 Thymidine Labeled Bone Marrow Cells in Irradiated Recipients

Description: It has been established by chromosome marker studies, histochemical, immunological, and cytological methods that the hemopoietic tissues of animals exposed to lethal doses of whole-body irradiation can be repopulated by transfused autologous, homologous or heterologous bone marrow cells. However, the morphology of the cell responsible for the regeneration of hematopoietic activity in the various hemopoietic organs has not been identified. It has been shown that the bone marrow contains the cell… more
Date: February 1, 1963
Creator: Fliedner, T. M.; Thomas, E. D.; Meyer, L. M. & Cronkite, E. P.
Partner: UNT Libraries Government Documents Department
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The Effects of Radiations of Different let on Early Responses in the Mammal

Description: This paper will first note briefly the place and status of radiobiotopical investigations with fast neutrons. The monoenergetic (fast) neutron technique employed at this laboratory will be then described and results of studies with various criteria-of-effect in the mouse will be reviewed. Finally, certain general patterns of response for these systems will be pointed out as functions of neutron energy.
Date: February 1, 1963
Creator: Bateman, J. L. & Bond, V. P.
Partner: UNT Libraries Government Documents Department
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