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Endothelial Cell Migration and Vascular Endothelial Growth Factor Expression Are the Result of Loss of Breast Tissue Polarity

Description: Recruiting a new blood supply is a rate-limiting step in tumor progression. In a three-dimensional model of breast carcinogenesis, disorganized, proliferative transformed breast epithelial cells express significantly higher expression of angiogenic genes compared with their polarized, growth-arrested nonmalignant counterparts. Elevated vascular endothelial growth factor (VEGF) secretion by malignant cells enhanced recruitment of endothelial cells (EC) in heterotypic cocultures. Significantly, p… more
Date: May 26, 2009
Creator: Chen, Amy; Cuevas, Ileana; Kenny, Paraic A; Miyake, Hiroshi; Mace, Kimberley; Ghajar, Cyrus et al.
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
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Enhancement of the RAD51 Recombinase Activity by the Tumor Suppressor PALB2

Description: Homologous recombination mediated by the RAD51 recombinase helps eliminate chromosomal lesions, such as DNA double-stranded breaks induced by radiation or arising from injured DNA replication forks. The tumor suppressors BRCA2 and PALB2 act together to deliver RAD51 to chromosomal lesions to initiate repair. Here we document a new function of PALB2 in the enhancement of RAD51's ability to form the D-loop. We show that PALB2 binds DNA and physically interacts with RAD51. Importantly, while PALB2… more
Date: August 24, 2010
Creator: Dray, Eloise; Etchin, Julia; Wiese, Claudia; Saro, Dorina; Williams, Gareth J.; Hammel, Michal et al.
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
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THE EFFECT OF EPINEPHRINE ON SERUM LIPOPROTEINS

Description: Epinephrine injection has been shown to produce a two and three fold increase of the higher Sf classes of serum lipoproteins in the rabbit. The previously observed elevation of serum lipids was confirmed. The hyperlipoproteinemia following epinephrine injection appears about the same time as in certain conditions of stress. (auth)
Date: November 21, 1957
Creator: Young, W. & Hayes, T.L.
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
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Breast cancer and personal environmental risk factors in Marin County - Pilot study

Description: The purpose of the Personal Environmental Risk Factor Study (PERFS) pilot project was to develop methodologies and a questionnaire for a future population-based case-control study to investigate the role of selected environmental exposures in breast cancer development. Identification of etiologically relevant exposures during a period of potential vulnerability proximate to disease onset offers the possibility of clinical disease prevention even when disease initiation may have already occurred… more
Date: February 1, 2003
Creator: Erdmann, C. A.; Farren, G.; Baltzell, K.; Chew, T.; Clarkson, C.; Fleshman, R. et al.
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
open access

Characterizing Tissue with Acoustic Parameters Derived from Ultrasound Data

Description: In contrast to standard reflection ultrasound (US), transmission US holds the promise of more thorough tissue characterization by generating quantitative acoustic parameters. We compare results from a conventional US scanner with data acquired using an experimental circular scanner operating at frequencies of 0.3 - 1.5 MHz. Data were obtained on phantoms and a normal, formalin-fixed, excised breast. Both reflection and transmission-based algorithms were used to generate images of reflectivity, … more
Date: January 23, 2002
Creator: Littrup, P.; Duric, N.; Leach, R. R.; Azevedo, S. G.; Candy, J. V.; Moore, T. et al.
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
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A prospective study of XRCC1 haplotypes and their interaction with plasma carotenoids on breast cancer risk

Description: The XRCC1 protein is involved in the base excision repair pathway through interactions with other proteins. Polymorphisms in the XRCC1 gene may lead to variation in repair proficiency and confer inherited predisposition to cancer. We prospectively assessed the associations between polymorphisms and haplotypes in XRCC1 and breast cancer risk in a nested case-control study within the Nurses' Health Study (incident cases, n 1004; controls, n 1385). We further investigated gene-environment interact… more
Date: January 15, 2004
Creator: Mohrenweiser, H W; Han, J; Hankinson, S E; De Vivo, I; Spiegelman, D; Tamimi, R M et al.
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
open access

Automated analysis for microcalcifications in high resolution digital mammograms

Description: Digital mammography offers the promise of significant advances in early detection of breast cancer. Our overall goal is to design a digital system which improves upon every aspect of current mammography technology: the x-ray source, detector, visual presentation of the mammogram and computer-aided diagnosis capabilities. This paper will discuss one part of our whole-system approach -- the development of a computer algorithm using gray-scale morphology to automatically analyze and flag microcalc… more
Date: October 1, 1994
Creator: Mascio, Laura N.; Hernandez, Jose M. & Logan, Clinton M.
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
open access

A Combined Scintimammography/Stereotactic Core Biopsy Digital X-ray System

Description: Jefferson Lab, Hampton University and the Riverside Regional Medical Center are collaborating in a clinical study employing a dual modality imaging system utilizing scintimammography and digital radiography. The purpose of the study is to obtain clinical data on the reliability of scintimammography in predicting the malignancy of suspected breast lesions with the ultimate goal to reduce the number of false positives associated with conventional x-ray mammography. The scintimammography gamma cam… more
Date: October 20, 2000
Creator: Weisenberger, A. G.; Barbosa, F.; Green, T. D.; Hoefer, R.; Keppel, C.; Kross, B. et al.
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
open access

Research on human genetics in Iceland. Progress report

Description: Records of the Icelandic Population are being used to investigate the possible inheritance of disabilities and diseases as well as other characters and the effect of environment on man. The progress report of research covers the period 1977 to 1980. The investigation was begun in 1965 by the Genetical Committee of the University of Iceland and the materials used are demographic records from the year 1840 to present and various medical information. The records are being computerized and linked t… more
Date: October 31, 1980
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
open access

Progress report on research on human genetics in Iceland

Description: Records of the Icelandic population are being used to investigate the possible inheritance of disabilities and diseases as well as other characteristics and the effect of environment on man. The progress report of research covers the period from 1977 to 1980. The investigation was begun in 1965 by the Genetical Committee of the University of Iceland and the materials used are demographic records from the year 1840 to present and various medical information. The records are being computerized an… more
Date: October 31, 1980
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
open access

Dose-projection considerations for emergency conditions at nuclear power plants

Description: The purpose of this report is to review the problems and issues associated with making environmental radiation-dose projections during emergencies at nuclear power plants. The review is divided into three areas: source-term development, characterization of atmospheric dispersion and selection of appropriate dispersion models, and development of dosimetry calculations for determining thyroid dose and whole-body dose for ground-level and elevated releases. A discussion of uncertainties associated… more
Date: May 1, 1983
Creator: Stoetzel, G.A.; Ramsdell, J.V.; Poeton, R.W.; Powell, D.C. & Desrosiers, A.E.
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
open access

Short Term Effects of External Electric Fields on Electrical Activity of the Pineal Gland in Rats

Description: The effects of short term exposure (5 minutes) to EEFs at relatively high dosages (10, 25, 39, kV/m) on the electrical activity in rat pineal glands was studied. Daytime and nighttime recordings were taken from an implanted microelectrode in the gland. The data show that (1) both the activity and frequency were enhanced when the animals were exposed to EEFs at 39 kV/m continuously and discontinuously; (2) the later condition yielded a sustained increase (36%) whereas the former a brief (10 sec)… more
Date: May 1996
Creator: Vu, Hung Quoc
Item Type: Refine your search to only Thesis or Dissertation
Partner: UNT Libraries
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AZU-1: A Candidate Breast Tumor Suppressor and Biomarker for Tumor Progression

Description: To identify genes misregulated in the final stages of breast carcinogenesis, we performed differential display to compare the gene expression patterns of the human tumorigenic mammary epithelial cells, HMT-3522-T4-2, with those of their immediate premalignant progenitors, HMT-3522-S2. We identified a novel gene, called anti-zuai-1 (AZU-1), that was abundantly expressed in non- and premalignant cells and tissues but was appreciably reduced in breast tumor cell types and in primary tumors. The AZ… more
Date: February 4, 2000
Creator: Chen, Huei-Mei; Schmeichel, Karen L; Mian, I. Saira; Lelie`vre, Sophie; Petersen, Ole W & Bissell, Mina J
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
open access

An integrative genomic and proteomic analysis of PIK3CA, PTEN and AKT mutations in breast cancer

Description: Phosphatidylinositol-3-kinase (PI3K)/AKT pathway aberrations are common in cancer. By applying mass spectroscopy-based sequencing and reverse phase protein arrays to 547 human breast cancers and 41 cell lines, we determined the subtype specificity and signaling effects of PIK3CA, AKT and PTEN mutations, and the effects of PIK3CA mutations on responsiveness to PI3K inhibition in-vitro and on outcome after adjuvant tamoxifen. PIK3CA mutations were more common in hormone receptor positive (33.8%) … more
Date: May 6, 2008
Creator: Stemke-Hale, Katherine; Gonzalez-Angulo, Ana Maria; Lluch, Ana; Neve, Richard M.; Kuo, Wen-Lin; Davies, Michael et al.
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
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The Effect of Intermediate Filament Inhibitors on Steroidogenesis and Cytoskeleton in Y-1 Mouse Adrenal Tumor Cells

Description: When Y-1 mouse adrenal tumor cells were treated with sodium orthovanadate, an intermediate filament (IF) inhibitor in BHK21-F cells, there was no change in the amount of 20α-dihydroprogesterone produced. A neurofilament inhibitor, β, β'-iminodipropionitrile (IDPN), enhanced the ability of Y-1 cells to produce steroid in response to ACTH by acting on the plasma membrane. Electron microscopy of Y-1 cells extracted with Triton X-100 revealed that both vanadate and IDPN caused the aggregation of cy… more
Date: August 1982
Creator: Lee, Hyun Sook
Item Type: Refine your search to only Thesis or Dissertation
Partner: UNT Libraries
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Preparation of Single Cells for Imaging Mass Spectrometry

Description: Characterizing chemical changes within single cells is important for determining fundamental mechanisms of biological processes that will lead to new biological insights and improved disease understanding. Imaging biological systems with mass spectrometry (MS) has gained popularity in recent years as a method for creating precise chemical maps of biological samples. In order to obtain high-quality mass spectral images that provide relevant molecular information about individual cells, samples m… more
Date: October 24, 2007
Creator: Berman, E. S.; Fortson, S. L.; Kulp, K. S.; Checchi, K. D.; Wu, L.; Felton, J. S. et al.
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
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Investigation of near infrared autofluorescence imaging for the detection of breast cancer

Description: Detection of breast cancer in fresh tissue obtained from surgery is investigated using Near-infrared autofluorescence imaging under laser excitation at 532-nm and 632.8-nm. The differences in intensity between the three main components of breast tissue (cancer, fibrous and adipose) are estimated and compared to those obtained from cross-polarized light scattering images recorded under polarized illumination at 700-nm. The optical spectroscopic images for each tissue sample were subsequently com… more
Date: August 19, 2005
Creator: Demos, S. G.; Bold, R.; White, R. D. & Ramsamooj, R.
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
open access

Image quality in mammography

Description: In mammography, image quality is a function of the shape, size, and x-ray absorption properties of the anatomic part to be radiographed and of the lesion to be detected; it also depends on geometric unsharpness, and the resolution, characteristic curve and noise properties of the recording system. X-ray energy spectra, modulation transfer functions, Wiener spectra, characteristic and gradient curves, and radiographs of a breast phantom and of a resected breast specimen containing microcalcifica… more
Date: January 1, 1976
Creator: Haus, A. G.; Doi, K.; Metz, C. E. & Bernstein, J.
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
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Proliferation of Estrogen Receptor alpha Positive Mammary Epithelial Cells is Restrained by TGFbeta1 in Adult Mice

Description: Transforming growth factor {beta}1 (TGF{beta}1) is a potent inhibitor of mammary epithelial proliferation. In human breast, estrogen receptor {alpha} (ER{alpha}) cells rarely co-localize with markers of proliferation, but their increased frequency correlates with breast cancer risk. To determine whether TGF{beta}1 is necessary for the quiescence of ER{alpha}-positive population, we examined mouse mammary epithelial gland at estrus. Approximately 35% of cells showed TGF{beta}1 activation, which … more
Date: March 3, 2005
Creator: Ewan, Kenneth B.R.; Oketch-Rabah, Hellen A.; Ravani, Shraddha A.; Shyamala, G.; Moses, Harold L. & Barcellos-Hoff, Mary Helen
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
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Flor-Essence? Herbal Tonic Promotes Mammary Tumor Development in Sprague Dawley Rats

Description: Background: Women who are diagnosed with breast cancer often self-administer complementary and alternative medicines to augment their conventional treatments, improve health, or prevent recurrence. Flor-Essence{reg_sign} Tonic is a complex mixture of herbal extracts used by cancer patients because of anecdotal evidence that it can treat or prevent disease. Methods: Female Sprague Dawley rats were given water or exposed to 3% or 6% Flor-Essence{reg_sign} beginning at one day of age. Mammary tumo… more
Date: January 28, 2004
Creator: Bennett, L; Montgomery, J; Steinberg, S & Kulp, K
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
open access

Ultrasound Imaging Using Diffraction Tomography in a Cylindrical Geometry

Description: Tomographic images of tissue phantoms and a sample of breast tissue have been produced from an acoustic synthetic array system for frequencies near 500 kHz. The images for sound speed and attenuation show millimeter resolution and demonstrate the feasibility of obtaining high-resolution tomographic images with frequencies that can deeply penetrate tissue. The image reconstruction method is based on the Born approximation to acoustic scattering and is a simplified version of a method previously … more
Date: January 24, 2002
Creator: Chambers, D H & Littrup, P
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
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