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Extending the cereus group genomics to putative food-borne pathogens of different toxicity

Description: The cereus group represents sporulating soil bacteriacontaining pathogenic strains which may cause diarrheic or emetic foodpoisoning outbreaks. Multiple locus sequence typing revealed a presencein natural samples of these bacteria of about thirty clonal complexes.Application of genomic methods to this group was however biased due tothe major interest for representatives closely related to B. anthracis.Albeit the most important food-borne pathogens were not yet defined,existing dataindicate that… more
Date: August 24, 2006
Creator: Lapidus, Alla; Goltsman, Eugene; Auger, Sandrine; Galleron, Nathalie; Segurens, Beatrice; Dossat, Carole et al.
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
open access

Genome-wide experimental determination of barriers to horizontal gene transfer

Description: Horizontal gene transfer, in which genetic material is transferred from the genome of one organism to another, has been investigated in microbial species mainly through computational sequence analyses. To address the lack of experimental data, we studied the attempted movement of 246,045 genes from 79 prokaryotic genomes into E. coli and identified genes that consistently fail to transfer. We studied the mechanisms underlying transfer inhibition by placing coding regions from different species … more
Date: September 24, 2007
Creator: Rubin, Edward; Sorek, Rotem; Zhu, Yiwen; Creevey, Christopher J.; Francino, M. Pilar; Bork, Peer et al.
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
open access

Multi-Probe Investigation of Proteomic Structure of Pathogens

Description: Complete genome sequences are available for understanding biotransformation, environmental resistance and pathogenesis of microbial, cellular and pathogen systems. The present technological and scientific challenges are to unravel the relationships between the organization and function of protein complexes at cell, microbial and pathogens surfaces, to understand how these complexes evolve during the bacterial, cellular and pathogen life cycles, and how they respond to environmental changes, che… more
Date: January 24, 2008
Creator: Malkin, A J; Plomp, M; Leighton, T J; Vogelstein, B & Wheeler, K E
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
open access

Use of a transfected and amplified Drosophila heat shock promoter construction for inducible production of toxic mouse c-myc proteins in CHO cells

Description: After transfection and selection with methotrexate, CHO cell lines were established which contained up to 2000 copies of an expression vector for c-myc protein. The vector contained the Drosophila heat shock protein 70 (hsp70) promoter fused with the coding region of the mouse c-myc gene. Incubation of cells for up to 3 hours at 43/sup 0/C resulted in at least a 100-fold induction of recombinant c-myc mRNA. When cells were shifted back to 37/sup 0/C, within 1 to 4 hours, this RNA was translated… more
Date: July 24, 1987
Creator: Wurm, F.M.; Gwinn, K.A.; Papoulas, O.; Pallavicini, M. & Kingston, R.E.
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
open access

Final Report on Development of Thermoanaerobacterium saccharolyticum for the conversion of lignocellulose to ethanol

Description: This project addressed the need for economical technology for the conversion of lignocellulosic biomass to fuels, specifically the conversion of pretreated hardwood to ethanol. The technology developed is a set of strains of the bacterium Thermoanaerobacterium saccharolyticum and an associated fermentation process for pretreated hardwood. Tools for genetic engineering and analysis of the organism were developed, including a markerless mutation method, a complete genome sequence and a set of gen… more
Date: January 24, 2012
Creator: Herring, Christopher D.; Kenealy, William R.; Shaw, A. Joe; Raman, Babu; Tschaplinski, Timothy J.; Brown, Steven D. et al.
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
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Most of rare missense alleles in humans are deleterious:implications for evolution of complex disease and associationstudies

Description: The accumulation of mildly deleterious missense mutations inindividual human genomes has been proposed to be a genetic basis forcomplex diseases. The plausibility of this hypothesis depends onquantitative estimates of the prevalence of mildly deleterious de novomutations and polymorphic variants in humans and on the intensity ofselective pressure against them. We combined analysis of mutationscausing human Mendelian diseases, human-chimpanzee divergence andsystematic data on human SNPs and foun… more
Date: October 24, 2006
Creator: Kryukov, Gregory V.; Pennacchio, Len A. & Sunyaev, Shamil R.
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
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Science and Technology Challenges for Homeland Security

Description: Preventing and protecting against catastrophic terrorism is a complex and dynamic challenge. Small groups or individuals can use advanced technology to cause massive destruction, and the rapid pace of technology and ease of information dissemination continually gives terrorists new tools. A 100% defense is not possible. It's a numbers problem--there are simply too many possible targets to protect and too many potential attack scenarios and adversaries to defend against. However, science and tec… more
Date: March 24, 2006
Creator: Murray, C A
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
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High Performance for Labeling, Separation and Detection Methods for Genome Analysis 12

Description: OAK-B135 Our research efforts over the past year have focused on the development of advanced integrated PCR reactors on chips, the development of robust integrated valves, the development of integrated optical detectors, and the development of microdevices for performing integrated genetic analysis. The details of all the projects will be found in the listed papers.
Date: November 24, 2003
Creator: Mathies, Richard A.
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
open access

Insights into the genome evolution of Yersinia pestis through whole genome comparison with Yersinia pseudotuberculosis

Description: Yersinia pestis, the causative agent of plague, is a highly uniform clone that diverged recently from the enteric pathogen Yersinia pseudotuberculosis. Despite their close genetic relationship, they differ radically in their pathogenicity and transmission. Here we report the complete genomic sequence of Y. pseudotuberculosis IP32953 and its use for detailed genome comparisons to available Y. pestis sequences. Analyses of identified differences across a panel of Yersinia isolates from around the… more
Date: January 24, 2004
Creator: Souza, B; Stoutland, P; Derbise, A; Georgescu, A; Elliott, J; Land, M et al.
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
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2009 MICROBIAL POPULATION BIOLOGY GORDON RESEARCH CONFERENCES JULY 19-24,2009

Description: The 2009 Gordon Conference on Microbial Population Biology will cover a diverse range of cutting edge issues in the microbial sciences and beyond. Firmly founded in evolutionary biology and with a strongly integrative approach, past Conferences have covered a range of topics from the dynamics and genetics of adaptation to the evolution of mutation rate, community ecology, evolutionary genomics, altruism, and epidemiology. The 2009 Conference is no exception, and will include sessions on the evo… more
Date: July 24, 2009
Creator: Dean, Anthony
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
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Supervised and unsupervised discretization methods for evolutionary algorithms

Description: This paper introduces simple model-building evolutionary algorithms (EAs) that operate on continuous domains. The algorithms are based on supervised and unsupervised discretization methods that have been used as preprocessing steps in machine learning. The basic idea is to discretize the continuous variables and use the discretization as a simple model of the solutions under consideration. The model is then used to generate new solutions directly, instead of using the usual operators based on s… more
Date: January 24, 2001
Creator: Cantú-Paz, Erick
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
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Association of Host and Microbial Species Diversity across Spatial Scales in Desert Rodent Communities

Description: Article describes study in which researchers employed a natural gradient of rodent species richness and quantified bacterial communities in rodent blood at several hierarchical spatial scales to test the hypothesis that associations between host and microbial species diversity will be positive in communities dominated by organisms with broad niches sampled at large scales.
Date: October 24, 2014
Creator: Gavish, Yoni; Kedem, Hadar; Messika, Irit; Cohen, Carmit; Toh, Evelyn; Munro, Daniel et al.
Item Type: Refine your search to only Article
Partner: UNT College of Arts and Sciences
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Genome of Methylobacillus flagellatus, Molecular Basis for Obligate Methylotrophy, and Polyphyletic Origin of Methylotrophy

Description: Along with methane, methanol and methylated amines represent important biogenic atmospheric constituents; thus, not only methanotrophs but also nonmethanotrophic methylotrophs play a significant role in global carbon cycling. The complete genome of a model obligate methanol and methylamine utilizer, Methylobacillus flagellatus (strain KT) was sequenced. The genome is represented by a single circular chromosome of approximately 3 Mbp, potentially encoding a total of 2,766 proteins. Based on geno… more
Date: July 24, 2007
Creator: Chistoserdova, Ludmila; Lapidus, Alla; Han, Cliff; Goodwin, Lynne; Saunders, Liz; Brettin, Tom et al.
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
open access

Genetic Information: Legal Issues Relating to Discrimination and Privacy

Description: On June 26, 2000, in a special ceremony at the White House, the completion of the "rough draft" of the human genome was announced. This milestone, which has been compared to the discoveries of Galileo, and other advances in genetics have created novel legal issues relating to genetic information.
Date: January 24, 2001
Creator: Jones, Nancy Lee
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
open access

STI. DE-FG02-00ER1505 [Brief summary of 11th International Conference on Arabidopsis Research]

Description: The 11th International Conference on Arabidopsis Research was held in Madison, Wisconsin, June 24 through June 28, 2000. Arabidopsis thaliana has been the subject of genetic study for many years. However, during the last decade, the number of research laboratories using Arabidopsis as a model system has increased tremendously, and Arabidopsis is currently being used to study all aspects of plant biology. The rapid rate of progress in Arabidopsis research, including the completion of the genomic… more
Date: June 24, 2000
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
open access

Celebrating 20 Years of Genetic Discoveries in Legume Nodulation and Symbiotic Nitrogen Fixation

Description: This article is a review cataloging and contextualizing all of the plant genes currently known to be required for SNF in two model legume species, Medicago truncatula and Lotus japonicus, and two crop species, Glycine max (soybean) and Phaseolus vulgaris (common bean). The authors also briefly consider the future of SNF genetics in the era of pan-genomics and genome editing.
Date: October 24, 2019
Creator: Roy, Sonali; Liu, Wei; Nandety, Raja Sekhar; Crook, Ashley; Mysore, Kirankumar S.; Pislariu, Catalina I. et al.
Item Type: Refine your search to only Article
Partner: UNT College of Science
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