18 Matching Results

Search Results

Advanced search parameters have been applied.
in subjects: "Erythropoiesis"  
Results: 1 - 18
open access

Studies of Porphyrin Metabolism, 3. The Relation of Erythropoiesis to the Excretion of Coproporphyrin by Dogs and Rabbits, and to the Concentration of Coproporphyrin and Protoporphyrin in Rabbit Erythrocytes

Description: Report discussing studies regarding porphyrin excretion and hemoglobin metabolism in animals with phenylhydrazine anemia, and studies regarding the coproporphyrin and protoporphyrin in the red blood cells of rabbits.
Date: November 25, 1945
Creator: Schwartz, Samuel; Glickman, Marcia; Hunter, Rosie & Wallace, Jean
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
open access

Kinetics of Erythroblastic Cell Populations in the Dog, Studied with Tritiated Thymidine

Description: In the erythroblastic series of several species, including man and dog, nuclear pyknosis in the last stages of maturation, before nuclear extrusion, is accompanied by a loss of the ability to synthesize DNA (1, 5). Cells of this group never appear labeled during the first hour after injection of tritiated thymidine. Less mature erythroblastic cells appear labeled or not on early samples, according to their functional status in the cell cycle. DNA synthesis indeed is not seen just before, during… more
Date: 1962
Creator: Odartchenko, N.; Bond, V. P.; Feinendegen, L. E. & Cottier, H.
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
open access

Novel secreted isoform of adhesion molecule ICAM-4: Potential regulator of membrane-associated ICAM-4 interactions

Description: ICAM-4, a newly characterized adhesion molecule, is expressed early in human erythropoiesis and functions as a ligand for binding a4b1 and aV integrin-expressing cells. Within the bone marrow, erythroblasts surround central macrophages forming erythroblastic islands. Evidence suggests that these islands are highly specialized subcompartments where cell adhesion events, in concert with cytokines, play critical roles in regulating erythropoiesis and apoptosis. Since erythroblasts express a4b1 and… more
Date: February 18, 2003
Creator: Lee, Gloria; Spring, Frances A.; Parons, Stephen F.; Mankelow, Tosti J.; Peters, Luanne L.; Koury, Mark J. et al.
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
open access

Fox-2 Splicing Factor Binds to a Conserved Intron Motif to PromoteInclusion of Protein 4.1R Alternative Exon 16

Description: Activation of protein 4.1R exon 16 (E16) inclusion during erythropoiesis represents a physiologically important splicing switch that increases 4.1R affinity for spectrin and actin. Previous studies showed that negative regulation of E16 splicing is mediated by the binding of hnRNP A/B proteins to silencer elements in the exon and that downregulation of hnRNP A/B proteins in erythroblasts leads to activation of E16 inclusion. This paper demonstrates that positive regulation of E16 splicing can b… more
Date: March 1, 2006
Creator: Ponthier, Julie L.; Schluepen, Christina; Chen, Weiguo; Lersch,Robert A.; Gee, Sherry L.; Hou, Victor C. et al.
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
open access

Erythroblastic Islands: Specialized Mircoenvironmental Niches forErythropoiesis

Description: This review focuses on current understanding of molecular mechanisms operating within erythroblastic islands including cell-cell adhesion, regulatory feedback, and central macrophage function. RECENT FINDINGS: Erythroblasts express a variety of adhesion molecules and recently two interactions have been identified that appear to be critical for island integrity. Erythroblast macrophage protein, expressed on erythroblasts and macrophages, mediates cell-cell attachments via homophilic binding. Ery… more
Date: January 6, 2006
Creator: Chasis, Joel Anne
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
open access

Alternative pre-mRNA splicing switches modulate gene expression in late erythropoiesis

Description: Differentiating erythroid cells execute a unique gene expression program that insures synthesis of the appropriate proteome at each stage of maturation. Standard expression microarrays provide important insight into erythroid gene expression but cannot detect qualitative changes in transcript structure, mediated by RNA processing, that alter structure and function of encoded proteins. We analyzed stage-specific changes in the late erythroid transcriptome via use of high-resolution microarrays t… more
Date: February 3, 2009
Creator: Yamamoto, Miki L.; Clark, Tyson A.; Gee, Sherry L.; Kang, Jeong-Ah; Schweitzer, Anthony C.; Wickrema, Amittha et al.
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
open access

Chromatin condensation in terminally differentiating mouse erythroblasts does not involve special architectural proteins but depends on histone deacetylation

Description: Terminal erythroid differentiation in vertebrates is characterized by progressive heterochromatin formation, chromatin condensation and, in mammals, culminates in nuclear extrusion. To date, although mechanisms regulating avian erythroid chromatin condensation have been identified, little is known regarding this process during mammalian erythropoiesis. To elucidate the molecular basis for mammalian erythroblast chromatin condensation, we used Friend virus-infected murine spleen erythroblasts th… more
Date: August 21, 2008
Creator: Popova, Evgenya Y.; Krauss, Sharon Wald; Short, Sarah A.; Lee, Gloria; Villalobos, Jonathan; Etzell, Joan et al.
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
open access

Targeted Gene Deletion Demonstrates that Cell Adhesion MoleculeICAM-4 is Critical for Erythroblastic Island Formation

Description: Erythroid progenitors differentiate in erythroblastic islands, bone marrow niches composed of erythroblasts surrounding a central macrophage. Evidence suggests that within islands adhesive interactions regulate erythropoiesis and apoptosis. We are exploring whether erythroid intercellular adhesion molecule-4 (ICAM-4), animmunoglobulin superfamily member, participates in island formation. Earlier, we identified alpha V integrins as ICAM-4 counter receptors. Since macrophages express alpha V, ICA… more
Date: February 15, 2006
Creator: Lee, Gloria; Lo, Annie; Short, Sarah A.; Mankelow, Tosti J.; Spring, Frances; Parsons, Stephen F. et al.
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
open access

Nuclear substructure reorganization during late stageerythropoiesis is selective and does not involve caspase cleavage ofmajor nuclear substructural proteins

Description: Enucleation, a rare feature of mammalian differentiation, occurs in three cell types: erythroblasts, lens epithelium and keratinocytes. Previous investigations suggest that caspase activation functions in lens epithelial and keratinocyte enucleation, as well as in early erythropoiesis encompassing BFU-E differentiation to proerythroblast. To determine whether caspase activation contributes to later erythropoiesis and whether nuclear substructures other than chromatin reorganize, we analyzed dis… more
Date: April 6, 2005
Creator: Krauss, Sharon Wald; Lo, Annie J.; Short, Sarah A.; Koury, MarkJ.; Mohandas, Narla & Chasis, Joel Anne
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
open access

Hemopoietic cell precursor responses to erythropoietin in plasma clot cultures

Description: The time dependence of the response of mouse bone marrow cells to erythropoietin (Ep) in vitro was studied. Experiments include studies on the Ep response of marrow cells from normal, plethoric, or bled mice. Results with normal marrow reveal: (1) Not all erythroid precursors (CFU-E) are alike in their response to Ep. A significant number of the precursors develop to a mature erythroid colony after very short Ep exposures, but they account for only approx. 13% of the total colonies generated wh… more
Date: January 1, 1979
Creator: Kennedy, W.L.
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
open access

Basic study on the role of thymus in hemopoietic differentiation

Description: Marrow, after in vitro treatment with either ..cap alpha.. Thy 1.2 or nonimmune serum and complement, was transplanted to separate groups of lethally irradiated isogenic mice. Mice of several different genotypes were used in 12 studies. Macroscopic spleen colony numbers were similar in the two groups, but differences were found when spleens were examined microscopically. The most striking and consistent finding was a decrease in granulopoietic colonies in recipients of ..cap alpha.. Thy 1.2 tre… more
Date: January 1, 1977
Creator: Goodman, J W; Basford, N L & Shinpock, S G
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
Back to Top of Screen