DNA Repair Decline During Mouse Spermiogenesis Results in the Accumulation of Heritable DNA Damage
Description:
The post-meiotic phase of mouse spermatogenesis (spermiogenesis) is very sensitive to the genomic effects of environmental mutagens because as male germ cells form mature sperm they progressively lose the ability to repair DNA damage. We hypothesized that repeated exposures to mutagens during this repair-deficient phase result in the accumulation of heritable genomic damage in mouse sperm that leads to chromosomal aberrations in zygotes after fertilization. We used a combination of single or fr…
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Date:
December 1, 2007
Creator:
Marchetti, Francesco; Marchetti, Francesco & Wyrobek, Andrew J.
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Partner:
UNT Libraries Government Documents Department