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BLIP: the Brookhaven linac isotope producer program

Description: The BLIP serves as a beam stop snd utilizes the excess beam capacity of the 200-MeV proton injector linac for the Alternatmg Gradient Synchrotron. The primary objective of the BLIP program is the development of improved radiopharmaceuticals. The production methods for iron-52, xenon-127, and xenon- 123 are outlined, and research work on the production of other radioisotopes is summarized. (WHK)
Date: April 30, 1974
Creator: Lebowitz, E.; Richards, P. & Stang, L.G. Jr.
Partner: UNT Libraries Government Documents Department


Description: The new Isotope Production Facility (IPF) at Los Alamos National Laboratory has been commissioned during the spring of 2004. Commissioning activities focused on the establishment of a radionuclide database, the review and approval of two specific target stack designs, and four trial irradiation runs with subsequent chemical processing and data analyses. This paper highlights some aspects of the facility and the targetry of the two approved target stacks used during the commissioning process.
Date: October 5, 2004
Creator: Nortier, F.M.; Fassbender, M.E.; DeJohn, M.; Hamilton, V.T.; Heaton, R.C.; Jamriska, D.J. et al.
Partner: UNT Libraries Government Documents Department

National Biomedical Tracer Facility. Project definition study

Description: We request a $25 million government-guaranteed, interest-free loan to be repaid over a 30-year period for construction and initial operations of a cyclotron-based National Biomedical Tracer Facility (NBTF) in North Central Texas. The NBTF will be co-located with a linear accelerator-based commercial radioisotope production facility, funded by the private sector at approximately $28 million. In addition, research radioisotope production by the NBTF will be coordinated through an association with an existing U.S. nuclear reactor center that will produce research and commercial radioisotopes through neutron reactions. The combined facilities will provide the full range of technology for radioisotope production and research: fast neutrons, thermal neutrons, and particle beams (H{sup -}, H{sup +}, and D{sup +}). The proposed NBTF facility includes an 80 MeV, 1 mA H{sup -} cyclotron that will produce proton-induced (neutron deficient) research isotopes.
Date: February 14, 1995
Creator: Schafer, R.
Partner: UNT Libraries Government Documents Department

Report to the Nuclear energy Research Advisory Committee (NERAC) Subcommittee on "Long-Term Isotope Research and Productions Plan" - Responses to Questions

Description: This report presents responses to two series of questions that were raised by a subcommittee of the Nuclear Energy Research Advisory Committee (NERAC) that has been charged with producing a ''Long-Term Isotope Research and Production Plan.'' The NERAC subcommittee is chaired by Dr. Richard Reba, and the Hanford Site Visit team, which comprises a subset of the subcommittee members, is chaired by Dr. Thomas Ruth. The first set of questions raised by the subcommittee on isotope production at the Hanford Site was received from Dr. Ruth on May 10, 1999, and the second set was received from him on July 5, 1999. Responses to the first set of questions were prepared as part of a June 1999 report entitled ''Isotope Production at the Hanford Site in Richland, Washington'' (PNNL 1999a). The responses to these questions are summarized in this document, with frequent references to the June 1999 report for additional details. Responses to the second set of questions from the NERAC subcommittee are presented in this document for the first time.
Date: July 1, 1999
Creator: Ammoniums
Partner: UNT Libraries Government Documents Department

Position measurements for the isotope production facility and the switchyard kicker upgrade projects

Description: The Los Alamos Neutron Science Center (LANSCE) is installing two beam lines to both improve operational tuning and provide new capabilities within the facility. The Isotope Production Facility (IPF) will provide isotopes for medical purposes by using the H' beam spur at 100 MeV and the Switchyard Kicker Upgrade (SYK) will allow the LANSCE 800-MeV H beam to be rapidly switched between various beam lines within the facility. The beam position measurements for both of these beam lines uses a standard micro-stripline beam position monitor (BPM) with both a 50-mm and 75-mm radius. The cable plant is unique in that it unambiguously provides a method of verifying the operation of the complete position measurement. The processing electronics module uses a log ratio technique with error corrections such that it has a dynamic range of -12 dBm to -85 dBm with errors less than 0.15 dB within this range. This paper will describe the primary components of these measurement systems and provide initial data of their operation.
Date: January 1, 2003
Creator: Gilpatrick, J. D. (John Douglas); Barr, D. S. (Dean S.); O'Hara, J. F. (James F.); Shurter, R. B. (Robert B.); Stettler, M. W. (Matthew W.) & Martinez, D. G. (Derwin G.)
Partner: UNT Libraries Government Documents Department

Letter to Eduard Smetanin, dated March 2, 2007: Final CRADA report.

Description: The IPP/DOE program office has finished its evaluation of the alpha-emitting isotope work with Kurchatov Institute and IPPE, and they have made an important decision about the future of this work. IPP/DOE has directed us to re-program the work and add more funds, so the emphasis will be on production of Th228. By making this re-direction of the isotope work, IPPE will see several important benefits: (a) the payments will be made faster to IPPE by using the ISTC Agreement; (b) a larger amount of money will be paid to IPPE; and (c) a profitable future business opportunity for IPPE is more probable.
Date: March 2, 2007
Creator: Ehst, D. A.
Partner: UNT Libraries Government Documents Department

Production of Ra225 precursor for Ac225/Bi213 generators. Final CRADA Report.

Description: Russian subcontractors shipped two small deliveries of Ra225 to PNNL for evaluation. The activity was close to the requisite amount in the subcontract. The first labeled properly; the second did not. This showed that the Russians could supply Ra225 to the US; however they proved unable to meet future demands for larger amounts of activity. The US DOE attempts to get Ra225 from Russian should be terminated; the Russians, under Rosatom, are not interested in this business.
Date: October 2, 2009
Creator: Ehst, D. A.
Partner: UNT Libraries Government Documents Department

Scoping assessment on medical isotope production at the Fast Flux Test Facility

Description: The Scoping Assessment addresses the need for medical isotope production and the capability of the Fast Flux Test Facility to provide such isotopes. Included in the discussion are types of isotopes used in radiopharmaceuticals, which types of cancers are targets, and in what way isotopes provide treatment and/or pain relief for patients.
Date: August 29, 1997
Creator: Scott, S.W.
Partner: UNT Libraries Government Documents Department

A Thermal/Hydraulic Safety Assessment of the Blanket Conceptual Design for the Accelerator Production of Tritium Facility

Description: In support of the Accelerator Production of Tritium (APT) project, safety analyses for the blanket system have been performed based on the conceptual design for the Target/Blanket (T/B) Facility. During mitigated event sequences safety engineered features, such as the residual heat removal (RHR) and cavity flood systems, provide sufficient protection for maintaining the structural integrity of the blanket system and its components. During unmitigated (with beam shutdown only) event sequences, passive features such as natural circulation, thermal inertia, and boil-off provide significant time for corrective measures to be taken.
Date: September 1, 1998
Creator: Hamm, L.L.; Lee, S.Y.; Shadday, M.A. & Smith, F.G. III
Partner: UNT Libraries Government Documents Department

A 3He{sup +}{sup +} RFQ accelerator for the production of PET isotopes

Description: Project status of the 3He{sup +}{sup +} 10.5 MeV RFQ Linear Accelerator for the production of PET isotopes will be presented. The accelerator design was begun in September of 1995 with a goal of completion and delivery of the accelerator to BRF in Shreveport, Louisiana by the summer of 1997. The design effort and construction is concentrated in Lab G on the Fermilab campus. Some of the high lights include a 25 mA peak current 3He` ion source, four RFQ accelerating stages that are powered by surplus Fermilab linac RF stations, a gas jet charge doubler, and a novel 540 degree bending Medium Energy Beam Transport (MEBT). The machine is designed to operate at 360 Hz repetition rate with a 2.5% duty cycle. The average beam current is expected to be 150-300 micro amperes electrical, 75- 150 micro amperes particle current.
Date: May 1, 1997
Creator: Pasquinelli, R.J. & Collaboration, E887
Partner: UNT Libraries Government Documents Department

Isotope production target irradiation experience at the annular core research reactor

Description: As a result of an Environmental Impact Statement (EIS) recently issued by the Department of Energy, Sandia National Laboratories (SNL) has been selected as the {open_quotes}most appropriate facility{close_quotes} for the production of {sup 99}Mo. The daughter product of {sup 99}Mo is {sup 99m}Tc, a radioisotope used in 36,000 medical procedures per day in the U.S.{close_quote} At SNL, the {sup 99}Mo would be created by the fission process in UO{sub 2} coated {open_quotes}targets{close_quotes} and chemically separated in the SNL Hot Cell Facility (HCF). SNL has recently completed the irradiation of five production targets at its Annular Core Research Reactor (ACRR). Following irradiation, four of the targets were chemically processed in the HCF using the Cintichem process.
Date: February 1, 1997
Creator: Talley, D.G.
Partner: UNT Libraries Government Documents Department

Magnet design concepts for the 100 MeV isotope production facility

Description: The North Port Target Facility proposal includes a 100 MeV beam line to be is built at the LANSCE accelerator. In developing cost and schedule estimates for the proposal the greatest uncertainties are associated with the kicker magnet that is needed to divert portions of the beam into the new beam line. This magnet must fit into a rigidly defined space within the transition region of the existing accelerator and must operate in synchrony with the current accelerator operations systems, In addition, it must not degrade the beam qualify when beam is directed to other areas of the complex. Because of these constraints the magnet must be specifically designed and built for this intended application. We have produced conceptual designs of a kicker-magnet and power supply that will meet all of the design requirements. The power supply design is based on a working design for the RIKI kicker magnet that switches 800 MeV beam into the PSR. This report presents the kicker-magnet and power-supply designs and cost and schedule estimates for incorporation into the EP facility proposal. The feasibility of various design alternatives are briefly discussed.
Date: October 7, 1996
Creator: Wadlinger, E.A.; Merrill, F.E. & Power, J.F.
Partner: UNT Libraries Government Documents Department

A new optical design for the BNL isotope production transport line

Description: The 200 MeV linac at BNL has recently been upgraded. As a result, 2.5 times more average beam current can be delivered to the Brookhaven Isotope Resource Center (BIRC), formerly called BLIP, a facility which produces radionuclides and radiopharmaceutical for the medical community, and also supports a research program seeking more effective diagnostic and therapeutic agents. The optics of the beam transport line to BIRC was redesigned to (a) reduce transverse fluctuations of the beam at the target due to any linac energy fluctuations, (b) produce a flat beam distribution at the target, in order to avoid melting certain target materials, and (c) handle the higher beam intensity while keeping radiation levels low. A profile monitor was also modified to monitor the flatness of the beam using the algebraic reconstruction technique (ART). The above improvements will be described, and results of the commissioning of the line during the 1996 running period will be discussed.
Date: October 1, 1996
Creator: Kponou, A.; Alessi, J.G.; Raparia, D.; Mapes, M. & Tsoupas, N.
Partner: UNT Libraries Government Documents Department

Development of the accelerator-driven energy production concept

Description: This is the final report of a three-year, Laboratory-Directed Research and Development (LDRD) project at the Los Alamos National Laboratory (LANL). Accelerator Driven Transmutation Technology (ADTT) offers a means of generating nuclear energy in a clean, safe way that can be attractive to the general public. However, there are issues associated with the energy story (both at the system level and technical detail) that have to be seriously addressed before the scientific community, the public, and potential industrial sponsors can be compellingly convinced of its cost/benefit.
Date: October 1, 1996
Creator: Venneri, F.; Beard, C. & Bowman, C.
Partner: UNT Libraries Government Documents Department