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Description: The new Isotope Production Facility (IPF) at Los Alamos National Laboratory has been commissioned during the spring of 2004. Commissioning activities focused on the establishment of a radionuclide database, the review and approval of two specific target stack designs, and four trial irradiation runs with subsequent chemical processing and data analyses. This paper highlights some aspects of the facility and the targetry of the two approved target stacks used during the commissioning process.
Date: October 5, 2004
Creator: Nortier, F.M.; Fassbender, M.E.; DeJohn, M.; Hamilton, V.T.; Heaton, R.C.; Jamriska, D.J. et al.
Partner: UNT Libraries Government Documents Department

BLIP: the Brookhaven linac isotope producer program

Description: The BLIP serves as a beam stop snd utilizes the excess beam capacity of the 200-MeV proton injector linac for the Alternatmg Gradient Synchrotron. The primary objective of the BLIP program is the development of improved radiopharmaceuticals. The production methods for iron-52, xenon-127, and xenon- 123 are outlined, and research work on the production of other radioisotopes is summarized. (WHK)
Date: April 30, 1974
Creator: Lebowitz, E.; Richards, P. & Stang, L.G. Jr.
Partner: UNT Libraries Government Documents Department

National Biomedical Tracer Facility. Project definition study

Description: We request a $25 million government-guaranteed, interest-free loan to be repaid over a 30-year period for construction and initial operations of a cyclotron-based National Biomedical Tracer Facility (NBTF) in North Central Texas. The NBTF will be co-located with a linear accelerator-based commercial radioisotope production facility, funded by the private sector at approximately $28 million. In addition, research radioisotope production by the NBTF will be coordinated through an association with an existing U.S. nuclear reactor center that will produce research and commercial radioisotopes through neutron reactions. The combined facilities will provide the full range of technology for radioisotope production and research: fast neutrons, thermal neutrons, and particle beams (H{sup -}, H{sup +}, and D{sup +}). The proposed NBTF facility includes an 80 MeV, 1 mA H{sup -} cyclotron that will produce proton-induced (neutron deficient) research isotopes.
Date: February 14, 1995
Creator: Schafer, R.
Partner: UNT Libraries Government Documents Department

Scoping assessment on medical isotope production at the Fast Flux Test Facility

Description: The Scoping Assessment addresses the need for medical isotope production and the capability of the Fast Flux Test Facility to provide such isotopes. Included in the discussion are types of isotopes used in radiopharmaceuticals, which types of cancers are targets, and in what way isotopes provide treatment and/or pain relief for patients.
Date: August 29, 1997
Creator: Scott, S.W.
Partner: UNT Libraries Government Documents Department

A Thermal/Hydraulic Safety Assessment of the Blanket Conceptual Design for the Accelerator Production of Tritium Facility

Description: In support of the Accelerator Production of Tritium (APT) project, safety analyses for the blanket system have been performed based on the conceptual design for the Target/Blanket (T/B) Facility. During mitigated event sequences safety engineered features, such as the residual heat removal (RHR) and cavity flood systems, provide sufficient protection for maintaining the structural integrity of the blanket system and its components. During unmitigated (with beam shutdown only) event sequences, passive features such as natural circulation, thermal inertia, and boil-off provide significant time for corrective measures to be taken.
Date: September 1, 1998
Creator: Hamm, L.L.; Lee, S.Y.; Shadday, M.A. & Smith, F.G. III
Partner: UNT Libraries Government Documents Department

A 3He{sup +}{sup +} RFQ accelerator for the production of PET isotopes

Description: Project status of the 3He{sup +}{sup +} 10.5 MeV RFQ Linear Accelerator for the production of PET isotopes will be presented. The accelerator design was begun in September of 1995 with a goal of completion and delivery of the accelerator to BRF in Shreveport, Louisiana by the summer of 1997. The design effort and construction is concentrated in Lab G on the Fermilab campus. Some of the high lights include a 25 mA peak current 3He` ion source, four RFQ accelerating stages that are powered by surplus Fermilab linac RF stations, a gas jet charge doubler, and a novel 540 degree bending Medium Energy Beam Transport (MEBT). The machine is designed to operate at 360 Hz repetition rate with a 2.5% duty cycle. The average beam current is expected to be 150-300 micro amperes electrical, 75- 150 micro amperes particle current.
Date: May 1, 1997
Creator: Pasquinelli, R.J. & Collaboration, E887
Partner: UNT Libraries Government Documents Department

Isotope production target irradiation experience at the annular core research reactor

Description: As a result of an Environmental Impact Statement (EIS) recently issued by the Department of Energy, Sandia National Laboratories (SNL) has been selected as the {open_quotes}most appropriate facility{close_quotes} for the production of {sup 99}Mo. The daughter product of {sup 99}Mo is {sup 99m}Tc, a radioisotope used in 36,000 medical procedures per day in the U.S.{close_quote} At SNL, the {sup 99}Mo would be created by the fission process in UO{sub 2} coated {open_quotes}targets{close_quotes} and chemically separated in the SNL Hot Cell Facility (HCF). SNL has recently completed the irradiation of five production targets at its Annular Core Research Reactor (ACRR). Following irradiation, four of the targets were chemically processed in the HCF using the Cintichem process.
Date: February 1, 1997
Creator: Talley, D.G.
Partner: UNT Libraries Government Documents Department

Magnet design concepts for the 100 MeV isotope production facility

Description: The North Port Target Facility proposal includes a 100 MeV beam line to be is built at the LANSCE accelerator. In developing cost and schedule estimates for the proposal the greatest uncertainties are associated with the kicker magnet that is needed to divert portions of the beam into the new beam line. This magnet must fit into a rigidly defined space within the transition region of the existing accelerator and must operate in synchrony with the current accelerator operations systems, In addition, it must not degrade the beam qualify when beam is directed to other areas of the complex. Because of these constraints the magnet must be specifically designed and built for this intended application. We have produced conceptual designs of a kicker-magnet and power supply that will meet all of the design requirements. The power supply design is based on a working design for the RIKI kicker magnet that switches 800 MeV beam into the PSR. This report presents the kicker-magnet and power-supply designs and cost and schedule estimates for incorporation into the EP facility proposal. The feasibility of various design alternatives are briefly discussed.
Date: October 7, 1996
Creator: Wadlinger, E.A.; Merrill, F.E. & Power, J.F.
Partner: UNT Libraries Government Documents Department

A new optical design for the BNL isotope production transport line

Description: The 200 MeV linac at BNL has recently been upgraded. As a result, 2.5 times more average beam current can be delivered to the Brookhaven Isotope Resource Center (BIRC), formerly called BLIP, a facility which produces radionuclides and radiopharmaceutical for the medical community, and also supports a research program seeking more effective diagnostic and therapeutic agents. The optics of the beam transport line to BIRC was redesigned to (a) reduce transverse fluctuations of the beam at the target due to any linac energy fluctuations, (b) produce a flat beam distribution at the target, in order to avoid melting certain target materials, and (c) handle the higher beam intensity while keeping radiation levels low. A profile monitor was also modified to monitor the flatness of the beam using the algebraic reconstruction technique (ART). The above improvements will be described, and results of the commissioning of the line during the 1996 running period will be discussed.
Date: October 1, 1996
Creator: Kponou, A.; Alessi, J.G.; Raparia, D.; Mapes, M. & Tsoupas, N.
Partner: UNT Libraries Government Documents Department

Development of the accelerator-driven energy production concept

Description: This is the final report of a three-year, Laboratory-Directed Research and Development (LDRD) project at the Los Alamos National Laboratory (LANL). Accelerator Driven Transmutation Technology (ADTT) offers a means of generating nuclear energy in a clean, safe way that can be attractive to the general public. However, there are issues associated with the energy story (both at the system level and technical detail) that have to be seriously addressed before the scientific community, the public, and potential industrial sponsors can be compellingly convinced of its cost/benefit.
Date: October 1, 1996
Creator: Venneri, F.; Beard, C. & Bowman, C.
Partner: UNT Libraries Government Documents Department

United States Department of Energy Office of Nuclear Energy, Isotope Production and Distribution Program financial statements, September 30, 1996 and 1995

Description: The charter of the Department of Energy (DOE) Isotope Production and Distribution Program (Isotope Program) covers the production and sale of radioactive and stable isotopes, associated byproducts, surplus materials such as lithium, and related isotope services. Service provided include, but are not limited to, irradiation services, target preparation and processing, source encapsulation and other special preparations, analyses, chemical separations, and leasing of stable isotopes for research purposes. Isotope Program products and services are sold worldwide for use in a wide variety of research, development, biomedical, and industrial applications. This report presents the results of the independent certified public accountants` audit of the Isotope Production and Distribution Program`s (Isotope) financial statements as of September 30, 1996.
Date: April 1, 1997
Partner: UNT Libraries Government Documents Department

Improving cancer treatment with cyclotron produced radionuclides. Comprehensive progress report, February 1, 1992--July 15, 1995

Description: This research continues the long term goals of promoting nuclear medicine applications by improving the scientific basis for tumor diagnosis, treatment and treatment follow-up based on the use of cyclotron produced radiotracers in oncology. This program fits into the nuclear medicine component of DOE`s mission, which is aimed at enhancing the beneficial applications of radiation, radionuclides, and stable isotopes in the diagnosis, study and treatment of human diseases. The grant includes 3 interactive components: Radiochemistry/Cyclotron; Pharmacology/Immunology; and Imaging Physics. An essential strategy is as follows: novel radionuclides and radiotracers developed in the Radiochemistry/Section under the DOE grant during the 1992--1995 will be employed in the Pharmacology/Immunology component in the period 1996--1999. Imaging Physics resolves relevant imaging related physics issues that arise during the experimentation that results. In addition to the basic research mission, this project also provides a basis for training of research scientists in radiochemistry, immunology, bioengineering and imaging physics.
Date: July 17, 1995
Creator: Larson, S.M. & Finn, R.D.
Partner: UNT Libraries Government Documents Department

Development of a commissioning plan for the APT linac

Description: The Accelerator Production of Tritium (APT) facility is based on a linac which incorporates both normal-conducting and superconducting RF technology and accelerates a 100-mA cw proton beam to an energy of 1,030 MeV or higher, depending on the desired production rate. Commissioning plans to achieve full power operation with minimum beam-induced activation of components have been evolving. This paper presents the main issues and the basic approaches that are now being discussed.
Date: December 1998
Creator: Funk, L. W.; Crandall, K. R.; Gilpatrick, J. D.; Gray, E. R.; Regan, A. H.; Rohlev, A. et al.
Partner: UNT Libraries Government Documents Department

Waste Processing To Support {sup 99}Mo Production at Sandia National Laboratories

Description: As part of the Isotope Production Program at Sandia National Laboratories New Mexico (SNL/NM), procedures are being finalized for the production of {sup 99}Mo from the irradiation of {sup 235}U-coated stainless steel targets at the Technical Area (TA) V reactor and hot cell facilities. Methods have been identified and tested for the management of the non-product (waste) material as the final step in the production process. These methods were developed utilizing the waste material from a series of cold and hot tests, beginning with depleted uranium powder and culminating with a test involving an irradiated {sup 235}U target with an initial fission product inventory of approximately 18,000 Ci at the end of the irradiation cycle.
Date: June 1, 1997
Creator: Longley, Susan; Carson, Susan & McDonald, Marion
Partner: UNT Libraries Government Documents Department

Production of radionuclides and their migration in groundwater: a Fermilab case history model

Description: Particle accelerators that are buried underground like those at Fermilab create a condition where soil can be activated. Naturally percolating groundwater becomes contaminated by leaching out some of the radioactivity as it migrates through the soil to the underlying aquifer. The Fermilab Concentration Model was formulated to account for and combine the fundamental processes of production, leaching, and migration. Its general features are described, then site-specific data from one of the target stations are used to make calculations and compare them to regulatory limits and DOE guidelines.
Date: August 1, 1997
Creator: Malensek, A.J.
Partner: UNT Libraries Government Documents Department