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The Enigmatic Protein Kinase C-eta

Description: The purpose of this review article is to discuss how PKCη regulates various cellular processes that may contribute to its contrasting roles in cancer. Protein kinase C-eta (PKCη) is a unique member of the PKC family since its regulation is distinct from other PKC isozymes. PKCη was shown to regulate cell proliferation, differentiation and cell death.
Date: February 13, 2019
Creator: Basu, Alakananda
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Partner: UNT Health Science Center
open access

Thymus Functionality Needs More Than a Few TECs

Description: Article is a review exploring the contributions of the many stromal cell types participating in the formation, expansion, and contraction of the thymus under normal and pathophysiological processes. Such information will better inform approaches for restoring thymus functionality, including thymus organoid technologies, beneficial when an individuals’ own tissue is congenitally, clinically, or accidentally rendered non-functional.
Date: June 10, 2022
Creator: Bhalla, Pratibha; Su, Dong-Ming & van Oers, Nicolai S. C.
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Partner: UNT Health Science Center
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“Youth Are More Aware and Intelligent than Imagined”: The Mountain Air Youth Photovoice Project

Description: This article looks at respiratory illness in Appalachian Kentucky because it reports some of the highest rates of respiratory illness in the United States. As part of the Mountain Air Project, local youth were invited to share their perspectives on possible contributing factors to respiratory illness, and the authors undertook an exploratory study to determine the utility of photovoice to elicit such perspectives with this population. This study demonstrates the value of incorporating youth per… more
Date: October 11, 2019
Creator: Cardarelli, Katheryn M.; Paul, Marcy; May, Beverly; Dunfee, Madeline; Browning, Steven & Schoenberg, Nancy
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Partner: UNT Health Science Center
open access

Protein Modification by ADP-ribose via Acid-labile Linkages

Description: Article describing the preparation and chemical characterization of low molecular weight conjugates that were used as models for an acetal linkage between ADP-ribose and the hydroxyl group of a protein acceptor such as serine, threonine, tyrosine, hydroxyproline, or hydroxylysine residues. The amount of modification was approximately 16 pmol of ADP-ribose per mg of total protein, and proteins modified by acid-labile linkages were detected in all subcellular fractions examined, suggesting that t… more
Date: April 7, 1995
Creator: Cervantes-Laurean, Daniel; Loflin, Paul T.; Minter, David E.; Jacobson, Elaine L. & Jacobson, Myron K.
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Partner: UNT Health Science Center
open access

Expression and Function of Transient Receptor Potential Ankyrin 1 Ion Channels in the Caudal Nucleus of the Solitary Tract

Description: The article describes a study that tested and confirmed the hypothesis that TRPA1 expressed in the primary sensory afferents may modulate the function of second order NTS neurons. The expression of TRPA1 was detected in presynaptic locations, but not the somata of caudal NTS neurons that did not express TRPA1 mRNA or proteins. Moreover, caudal NTS neurons did not show somatodendritic responsiveness to TRPA1 agonists, while TRPA1 immunostaining was detected only in the afferent fibers.
Date: April 26, 2019
Creator: Feng, Lin; Uteshev, Victor V. & Premkumar, Louis S.
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Partner: UNT Health Science Center
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Transplanted Neural Stem Cells Modulate Regulatory T, γδ T Cells and Corresponding Cytokines after Intracerebral Hemorrhage in Rats

Description: Paper examines the effects of transplanted neural stem cells (NSCs) on subpopulations of T lymphocytes and their corresponding cytokines when used to treat brain injury, using rats as a case study.
Date: March 13, 2014
Creator: Gao, Lu; Lu, Qin; Huang, Li-Jie; Ruan, Lin-Hui; Yang, Jian-Jing; Huang, Wei-Long et al.
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Partner: UNT Health Science Center
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Transitioning from Acute to Chronic Pain: An Examination of Different Trajectories of Low-Back Pain

Description: The article examines the most recent trajectory research, and highlights the importance of developing a broader model for patient evaluation. Traditionally, there has been a widely accepted notion that the transition from acute to chronic pain follows a linear trajectory, where an injury leads to acute episodes, subacute stages, and progresses to a chronic pain condition. However, it appears that pain progression is much more complicated and individualized than this original unsupported assumpt… more
Date: May 17, 2018
Creator: Gatchel, Robert J.; Bevers, Kelley; Licciardone, John C.; Su, Jianzhong; Du, Ying & Brotto, Marco
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Partner: UNT Health Science Center
open access

Development of Biodegradable Nanocarriers Loaded with a Monoclonal Antibody

Description: This article examines the feasibility of encapsulating monoclonal antibodies within poly(lactic-co-glycolic acid) (PLGA) nanoparticles using a water/oil/water double emulsion solvent evaporation technique. This method can be used to prepare protective polymeric nanoparticles for transporting functional antibodies to the cytoplasmic compartment of cancer cells. The author's studies achieved successful formulation of antibody loaded polymeric nanoparticles, thus indicating that a PLGA-based antib… more
Date: February 12, 2015
Creator: Gdowski, Andrew; Ranjan, Amalendu; Mukerjee, Anindita & Vishwanatha, Jamboor
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Partner: UNT Health Science Center
open access

Harnessing Data to Assess Equity of Care by Race, Ethnicity and Language

Description: Study examines disparities in healthcare based on race, ethnicity and language (REaL) by utilizing inpatient (IP) core measures at Texas Health Resources, a large, faith-based, non-profit healthcare system located in Texas.
Date: December 22, 2015
Creator: Gracia, Amber; Cheirif, Jorge; Veliz, Juana; Reyna, Melissa; Vecchio, Mara & Aryal, Subhash
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Partner: UNT Health Science Center
open access

Pulmonary Carcinoid Surface Receptor Modulation Using Histone Deacetylase Inhibitors

Description: Study describes the use of a non-cytotoxic dose of histone deacetylase (HDAC) inhibitors to induce pulmonary carcinoid somatostatin receptor subtype 2 (SSTR2) expression to diagnose pulmonary carcinoids.
Date: June 3, 2019
Creator: Guenter, Rachael E.; Aweda, Tolulope; Matos, Danilea M. Carmona; Whitt, Jason; Chang, Alexander W.; Cheng, Eric Y. et al.
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Partner: UNT Health Science Center
open access

Treatment and Prevention of Recurrent Clostridium difficile Infection with Functionalized Bovine Antibody-Enriched Whey in a Hamster Primary Infection Model

Description: This article focuses on the development of an alternative drug for the treatment of Clostridium difficile infection (CDI). Oral administration of anti-CD-WPI is a functional therapy of CDI in infected hamsters for both primary treatment and prevention of recurrence. Thus, anti-CD-WPI could address the urgent unmet medical need for treating and preventing recurrent CDI in humans.
Date: February 6, 2019
Creator: Heidebrecht, Hans-Jürgen; Weiss, William J.; Pulse, Mark; Lange, Anton; Gisch, Karina; Kliem, Heike et al.
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Partner: UNT Health Science Center
open access

Safety of Continuous Infusion Ketorolac in Postoperative Coronary Artery Bypass Graft Surgery Patients

Description: This article evaluates the safety of continuous infusion ketorolac which is sometimes utilized for analgesia in postoperative coronary artery bypass graft (CABG) patients. This retrospective cohort study evaluated the primary outcome of mortality and secondary outcomes of incidence of bleeding and myocardial infarction (MI). No association was found between continuous infusion ketorolac and increased risk of mortality, MI, or bleeding events in postoperative CABG patients.
Date: June 28, 2016
Creator: Howard, Meredith L.; Warhurst, Robert D. & Sheehan, Courtney
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Partner: UNT Health Science Center
open access

Sarcoidosis and Its Splenic Wonder: A Rare Case of Isolated Splenic Sarcoidosis

Description: This article is a case study discussing a case of a 40-year-old female with isolated splenic sarcoidosis found to have isolated splenomegaly with multiple hypodense splenic lesions and no other multisystem involvement. Isolated splenomegaly is very rare and an uncommon presentation of sarcoidosis. This case is clinically challenging because of the extensive differential diagnosis. The authors conclude that sarcoidosis of the spleen, although rare, should be considered in the differential diagno… more
Date: November 5, 2018
Creator: Jhaveri, Khushali & Surani, Salim R.
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Partner: UNT Health Science Center
open access

The Implications of Cancer Stem Cells for Cancer Therapy

Description: This review summarizes the characteristics, evidences and development of CSCs, as well as implications and challenges for cancer treatment. Surgery, radiotherapy and chemotherapy are universally recognized as the most effective anti-cancer therapies. Recent studies have showed that cancer stem cells (CSCs), a small subpopulation of tumor cells, can generate bulk populations of nontumorigenic cancer cell progeny through the self-renewal and differentiation processes.
Date: December 5, 2012
Creator: Jiang, Wenjing; Peng, Jianhua; Zhang, Yue; Cho, William C. S. & Jin, Kunlin
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Partner: UNT Health Science Center
open access

The Potential Role of Nanotechnology in Therapeutic Approaches for Triple Negative Breast Cancer

Description: This review is focused on opportunities for developing new approaches for filling the current void in an effective treatment for Triple Negative Breast Cancer, TNBC, patients. Triple Negative Breast Cancer, TNBC, a highly aggressive and metastatic type of breast cancer, is characterized by loss of expression of the estrogen receptor (ER), progesterone receptor (PR), and a lack of overexpression of the human epidermal growth factor receptor 2 (HER2).
Date: June 18, 2013
Creator: Johnson, Rebecca; Sabnis, Nirupama; McConathy, Walter J. & Lacko, Andras G.
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Partner: UNT Health Science Center
open access

Alcohol Withdrawal and Brain Injuries: Beyond Classical Mechanisms

Description: This review attempts to provide integrated information at the levels of oxidative signaling mechanisms by which ethanol withdrawal (EW) provokes brain injuries and 17β-estradiol (E2) protects against it. Unmanaged sudden withdrawal from the excessive consumption of alcohol (ethanol) adversely alters neuronal integrity in vulnerable brain regions such as the cerebellum, hippocampus, or cortex.
Date: July 20, 2010
Creator: Jung, Marianna E. & Metzger, Daniel B.
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Partner: UNT Health Science Center
open access

Copycats in Pilot Aircraft-Assisted Suicides after the Germanwings Incident

Description: Paper describes studying aiming to evaluate changes in pilot aircraft-assisted suicide risks, i.e., a copycat effect, in the U.S. and Germany after the Germanwings 2015 incident in the French Alps.
Date: March 11, 2018
Creator: Laukkala, Tanja; Vuorio, Alpo; Bor, Robert; Budowle, Bruce; Navathe, Pooshan; Pukkala, Eero et al.
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Partner: UNT Health Science Center
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