Detection of early malignant changes in tissue cultured cells using a novel tumorigenicity assay in nude mice
Description:
Cultured cells were tested for tumorigenicity in nude mice using a new test involving implantation of cells grown on small gelatin sponges. The test was applied to mouse, hamster, and human cells, and the results were compared to a conventional tumorigenicity assay (injection of cell suspensions). The sponge assay was at least as sensitive as the conventional assay in all cases tested so far. In several instances the sponge assay could detect events not seen in the standard assay. Use of the sp…
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Date:
January 1, 1979
Creator:
Wells, R. S.; Campbell, E. W.; Holland, L. M.; Schwartzendruber, D. E. & Kraemer, P. M.
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UNT Libraries Government Documents Department