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in subjects: "Spermatogenesis"  
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Chromosomal mosaicism in mouse two-cell embryos after paternal exposure to acrylamide

Description: Chromosomal mosaicism in human preimplantation embryos is a common cause ofspontaneous abortions, however, our knowledge of its etiology is limited. We used multicolor fluorescence in situ hybridization (FISH) painting to investigate whether paternally-transmitted chromosomal aberrations result in mosaicism in mouse 2-cell embryos. Paternal exposure to acrylamide, an important industrial chemical also found in tobacco smoke and generated during the cooking process of starchy foods, produced sig… more
Date: October 14, 2008
Creator: Marchetti, Francesco; Bishop, Jack; Lowe, Xiu & Wyrobek, Andrew J
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
open access

Detection of structural and numerical chomosomal abnormalities by ACM-FISH analysis in sperm of oligozoospermic infertility patients

Description: Modern reproductive technologies are enabling the treatment of infertile men with severe disturbances of spermatogenesis. The possibility of elevated frequencies of genetically and chromosomally defective sperm has become an issue of concern with the increased usage of intracytoplasmic sperm injection (ICSI), which can enable men with severely impaired sperm production to father children. Several papers have been published about aneuploidy in oligozoospermic patients, but relatively little is k… more
Date: November 10, 2003
Creator: Schmid, T. E.; Brinkworth, M. H.; Hill, F.; Sloter, E.; Kamischke, A.; Marchetti, F. et al.
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
open access

DNA repair decline during mouse spermiogenesis results in the accumulation of heritable DNA damage

Description: The post-meiotic phase of mouse spermatogenesis (spermiogenesis) is very sensitive to the genomic effects of environmental mutagens because as male germ cells form mature sperm they progressively lose the ability to repair DNA damage. We hypothesized that repeated exposures to mutagens during this repair-deficient phase result in the accumulation of heritable genomic damage in mouse sperm that leads to chromosomal aberrations in zygotes after fertilization. We used a combination of single or fr… more
Date: February 21, 2008
Creator: Marchetti, Francesco; Marchetti, Francesco & Wryobek, Andrew J
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
open access

DNA Repair Decline During Mouse Spermiogenesis Results in the Accumulation of Heritable DNA Damage

Description: The post-meiotic phase of mouse spermatogenesis (spermiogenesis) is very sensitive to the genomic effects of environmental mutagens because as male germ cells form mature sperm they progressively lose the ability to repair DNA damage. We hypothesized that repeated exposures to mutagens during this repair-deficient phase result in the accumulation of heritable genomic damage in mouse sperm that leads to chromosomal aberrations in zygotes after fertilization. We used a combination of single or fr… more
Date: December 1, 2007
Creator: Marchetti, Francesco; Marchetti, Francesco & Wyrobek, Andrew J.
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
open access

DNA repair efficiency in germ cells and early mouse embryos and consequences for radiation-induced transgenerational genomic damage

Description: Exposure to ionizing radiation and other environmental agents can affect the genomic integrity of germ cells and induce adverse health effects in the progeny. Efficient DNA repair during gametogenesis and the early embryonic cycles after fertilization is critical for preventing transmission of DNA damage to the progeny and relies on maternal factors stored in the egg before fertilization. The ability of the maternal repair machinery to repair DNA damage in both parental genomes in the fertilizi… more
Date: January 18, 2009
Creator: Marchetti, Francesco & Wyrobek, Andrew J.
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
open access

Effect of graded doses of ionizing radiation on the human testis. [X rays]

Description: Sixty-seven human subjects with normal testicular function were subjected to acute testicular irradiation in doses ranging from 8R to 600 R. Post irradiation observations included sperm counts and morphology, and radioimmunoassays for levels of reproductive steroids and hormones in urine (later plasma). Preliminary results and irradiation procedures are tabulated. An overview and analysis of results to date is published in a separate communication. (ERB)
Date: January 1, 1974
Creator: Rowley, M J; Leach, D R; Warner, G A & Heller, C G
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
open access

Molecular dosimetry of chemical mutagens: measurement of molecular dose and DNA repair germ cells

Description: Molecular dosimetry in the germ cells of male mice is reviewed with regard to in vivo alkylation of sperm heads, in vivo alkylation of sperm DNA, and possible alkylation of sperm protamine. DNA repair in male germ cells is reviewed with regard to basic design of experiments, DNA repair in various stages of spermatogenesis, effect of protamine on DNA repair following treatment with EMS or x radiation, and induction of DNA repair by methyl methanesulfonate, propyl methanesulfonate, and isopropyl … more
Date: January 1, 1975
Creator: Sega, G.A.
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
open access

Spermatogonial stem cell renewal in the mouse as revealed by $sup 3$H- thymidine labeling and irradiation

Description: Procedures are described for sectioning and staining mouse testes, x- irradiation of mice, and classification of developing sperm cells. Tables are presented to show frequency of labeled cells following exposure to various doses of x radiation. A discussion is presented of types of spermatogonia surviving various radiation doses and times of incorporation of $sup 3$H-TdR in the cycle of the seminiferous epithelium. Models of stem cell renewal systems are described. (HLW)
Date: January 1, 1975
Creator: Oakberg, E.F. & Huckins, C.
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
open access

"The Success of Captive Broodstock Programs Depends on High In-Culture Survival, ..." [from the Abstract], 2006-2007 Progress Report.

Description: The success of captive broodstock programs depends on high in-culture survival, appropriate development of the reproductive system, and the behavior and survival of cultured salmon after release, either as adults or juveniles. Continuing captive broodstock research designed to improve technology is being conducted to cover all major life history stages of Pacific salmon. Accomplishments detailed in this report are listed below by major objective. Objective 1: This study documented that captivel… more
Date: April 8, 2009
Creator: Berejikian, Barry A.
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
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