CHO/HGPRT mutagenicity assay. II. Genetic basis of 6-thioguanine resistance
Description:
An essential aspect of any attempt to study mutation induction in mammalian cells is the demonstration that genetic alterations are the bases for the altered phenotypes. We have defined reproducible conditions for the selection of 6-thioguanine-resistant (TG/sup r) variants of Chinese hamster ovary (CHO) cells. It is known that many such variants contain altered forms of the enzyme hypoxanthine (Hx)-guanine phosphoribosyl transferase (HGPRT). Our question was whether every variant colony which …
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Date:
January 1, 1979
Creator:
O'; Neill, J. P. & Hsie, A. W.
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