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Dose calculation and treatment planning for the Brookhaven NCT Facility

Description: Consistency of the calculated to measured fluxes and doses in phantoms is important for confidence in treatment planning for Boron Neutron Capture Therapy at the Brookhaven Medical Research Reactor (BMRR). Two phantoms have been used to measure the thermal and epithermal flux and gamma dose distributions for irradiations at the BMRR and these are compared to MCNP calculations. Since MCNP calculations in phantoms or models would be lengthy if the calculations started each time with fission neutr… more
Date: December 31, 1992
Creator: Liu, H. B. & Brugger, R. M.
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
open access

Dose calculation and treatment planning for the Brookhaven NCT Facility

Description: Consistency of the calculated to measured fluxes and doses in phantoms is important for confidence in treatment planning for Boron Neutron Capture Therapy at the Brookhaven Medical Research Reactor (BMRR). Two phantoms have been used to measure the thermal and epithermal flux and gamma dose distributions for irradiations at the BMRR and these are compared to MCNP calculations. Since MCNP calculations in phantoms or models would be lengthy if the calculations started each time with fission neutr… more
Date: January 1, 1992
Creator: Liu, H.B. & Brugger, R.M.
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
open access

An epithermal neutron beam from the MURR and from an accelerator source compared to the beam at the BMRR

Description: An ideal neutron beam for BNCT is a beam of epithermal neutrons, forward directed, and free of gamma rays and thermal and fast neutrons. Three neutron beams were evaluated, and compared: (1) the operating Brookhaven Medical Research Reactor (BMRR) epithermal beam, (2) the designed Missouri University Research Reactor (MURR) epithermal beam, and (3) the accelerator-based epithermal neutron beam designed by Wu. These neutron beams were compared with respect to the neutron spectra, neutron and gam… more
Date: December 31, 1992
Creator: Liu, H. B. & Brugger, R. M.
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
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Criticality evaluation for the storage of converter plates in drums

Description: A criticality safety evaluation was performed to support the temporary storage of 20%-enriched uranium converter plates for future use in the Brookhaven Medical Research Reactor (BMRR). A total of twelve such plates each containing approximately one kilogram of the {sup 235}U will be stored in DOT-certified 6M-drums, which have the same dimensions as standard 55-gallon drums except that they are twice as high (178.5cm). Each drum contains a Celotex liner surrounding a central 12.7cm-dia steel p… more
Date: December 31, 1993
Creator: Hu, J. P.; Rorer, D. C. & Liu, H. B.
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
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Doses delivered to normal brain under different treatment protocols at Brookhaven National Laboratory

Description: As of October 31, 1996, 23 glioblastoma multiforme patients underwent BNCT under several treatment protocols at the Brookhaven Medical Research Reactor. For treatment planning and dosimetry purposes, these protocols may be divided into four groups. The first group comprises protocols that used an 8-cm collimator and allowed a peak normal brain dose of 10.5 Gy-Eq to avolume of 1 cm{sup 3} were the thermal neutron flux was maximal (even if it happened to be in the tumor volume). The second group … more
Date: December 31, 1996
Creator: Capala, J.; Coderre, J.A. & Liu, H.B.
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
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A comparison of the dose RBE and the biological dosimetry approaches for treatment planning in BNCT

Description: Treatment planning for clinical trials with boron neutron capture therapy (BNCT) is complicated substantially by the fact that the radiation field generated by the activating external neutron beam is composed of several different types of radiation, i.e., fast neutrons, recoil protons from elastic collisions with hydrogen, gamma rays from the reactor and from neutron capture by body hydrogen, protons from nitrogen capture, and the products of the NCT interaction. Furthermore, the relative contr… more
Date: January 1, 1992
Creator: Laster, B. H.; Liu, H. B.; Gordon, C. R. & Bond, V. P.
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
open access

A comparison of the dose RBE and the biological dosimetry approaches for treatment planning in BNCT

Description: Treatment planning for clinical trials with boron neutron capture therapy (BNCT) is complicated substantially by the fact that the radiation field generated by the activating external neutron beam is composed of several different types of radiation, i.e., fast neutrons, recoil protons from elastic collisions with hydrogen, gamma rays from the reactor and from neutron capture by body hydrogen, protons from nitrogen capture, and the products of the NCT interaction. Furthermore, the relative contr… more
Date: December 31, 1992
Creator: Laster, B. H.; Liu, H. B.; Gordon, C. R. & Bond, V. P.
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
open access

Gadolinium as an element for neutron capture therapy

Description: At BNL, preparations are being made to test in vitro compounds containing Gd and compare their response to the response of GD-DTPA to determine if one or several compounds can be located that enter the cells and enhance the Auger effect. Two similar rotators with positions for cell vials that have been constructed for these tests. The first rotator is made of only paraffin which simulates healthy tissue and provides control curves. The second rotator has 135 ppM of Gd-157 in the paraffin to sim… more
Date: December 31, 1992
Creator: Brugger, R. M.; Liu, H. B.; Laster, B. H.; Gordon, C. R.; Greenberg, D. D. & Warkentien, L. S.
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
open access

Technical aspects of boron neutron capture therapy at the BNL Medical Research Reactor

Description: The Brookhaven Medical Research Reactor, BMRR, is a 3 MW heterogeneous, tank-type, light water cooled and moderated, graphite reflected reactor, which was designed for biomedical studies. Early BNL work in Boron Neutron Capture Therapy (BNCT) used a beam of thermal neutrons for experimental treatment of brain tumors. Research elsewhere and at BNL indicated that higher energy neutrons would be required to treat deep seated brain tumors. Epithermal neutrons would be thermalized as they penetrated… more
Date: July 1, 1997
Creator: Holden, N. E.; Rorer, D. C.; Patti, F. J.; Liu, H. B.; Reciniello, R. & Chanana, A. D.
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
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Boron neutron capture therapy of glioblastoma multiforme using the p- boronophenylalanine-fructose complex and epithermal neutrons

Description: The amino acid analogue p-boronophenylalanine (BPA) is under investigation as a neutron capture agent for BNCT of glioblastoma multiforme. A series of patients undergoing surgical removal of tumor received BPA orally as the free amino acid. Favorable tumor/blood boron concentration ratios were obtained but the absolute amount of boron in the tumor would have been insufficient for BNCT. BPA can be solubilized at neutral pH by complexation with fructose (BPA-F). Studies with rats suggest that int… more
Date: December 31, 1994
Creator: Coderre, J. A.; Chanana, A. D.; Joel, D. D.; Liu, H. B.; Slatkin, D. N.; Wielopolski, L. et al.
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
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