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Predicting incident cardiovascular disease among African-American adults: A deep learning approach to evaluate social determinants of health in the Jackson heart study

Description: Article describes how the authors' study sought to leverage machine learning approaches to determine whether social determinants of health improve prediction of incident cardiovascular disease (CVD). Participants in the Jackson Heart study with no history of CVD at baseline were followed over a 10-year period to determine first CVD events.
Date: November 10, 2023
Creator: Morris, Matthew C.; Moradi, Hamidreza; Aslani, Maryam; Sims, Mario; Schlundt, David; Kouros, Chrystyna D. et al.
Item Type: Refine your search to only Article
Partner: UNT College of Information
open access

Inhaled diesel exhaust particles result in microbiome‑related systemic inflammation and altered cardiovascular disease biomarkers in C57Bl/6 male mice

Description: Article discusses the authors' investigation the hypothesis that exposure to inhaled diesel exhaust particles alters the gut microbiome and promotes microbial-related inflammation and cardiovascular disease biomarkers. To determine whether probiotics could prevent diet or DEP exposure mediated alterations in the gut microbiome or systemic outcomes, a subset of animals on the HF diet were treated orally with 0.3 g/day (~ 7.5 × 108 CFU/day) of Winclove Ecologic® Barrier probiotics throughout the … more
Date: February 9, 2022
Creator: Phillippi, Danielle T.; Daniel, Sarah; Pusadkar, Vaidehi; Youngblood, Victoria L.; Nguyen, Kayla N.; Azad, Rajeev K. et al.
Item Type: Refine your search to only Article
Partner: UNT College of Science
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Genomics of Cardiometabolic Diseases in Mexican Americans

Description: Presentation on the importance of studying underrepresented ethnicities in genomics, in particular those Hispanic/Latino ancestry. It was presented at the UNT Transdisciplinary Conference on Ancestral Genomics Research which was held virtually on November 20-21, 2020.
Date: November 21, 2020
Duration: 28 minutes 44 seconds
Creator: Hidalgo, Bertha
Item Type: Refine your search to only Video
Partner: University of North Texas
captions transcript

How Tiny Zebrafish and Their Surprisingly Human-Like Genome Can Benefit Medical Research

Description: Presentation highlighting the use of zebrafish to identify genes relating to predisposition to thromboembolism and cardiovascular disease in people with African ancestry. It was presented at the UNT Transdisciplinary Conference on Ancestral Genomics Research which was held virtually on November 20-21, 2020.
Date: November 21, 2020
Duration: 16 minutes 54 seconds
Creator: Jagadeeswaran, Pudur
Item Type: Refine your search to only Video
Partner: University of North Texas
open access

Oral Spore-Based Probiotic Supplementation Was Associated With Reduced Incidence of Post-Prandial Dietary Endotoxin, Triglycerides, and Disease Risk Biomarkers

Description: This article contains a study to determine if 30-d of oral spore-based probiotic supplementation could reduce dietary endotoxemia.
Date: August 15, 2017
Creator: McFarlin, Brian K.; Henning, Andrea L.; Bowman, Erin M.; Gary, Melody A. & Carbajal, Kimberly M.
Item Type: Refine your search to only Article
Partner: UNT College of Science
open access

Co-Funding for the Conference on Magnetic Resonance in Biological Systems

Description: The XXIst International Conference on Magnetic Resonance in Biological Systems (ICMRBS 2005), '60th anniversary of the discovery of Nuclear Magnetic Resonance,' was held between 16 and 21 January 2005 in Hyderabad, India. The meeting focused on a broad range of magnetic resonance methods as applied to studies of biological processes related to human health. The biennial ICMRBS has become the major venue for discussion of advances in nuclear and electron magnetic resonance (NMR & EMR/EPR) studie… more
Date: October 1, 2008
Creator: Alan McLaughlin, Ph.D., Director, Division of Applied Science & Technology, NIBIB, NIH
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
open access

Surgical Robotics Research in Cardiovascular Disease

Description: This grant is to support a research in robotics at three major medical centers: the University of Southern California-USC- (Project 1); the University of Alabama at Birmingham-UAB-(Project 2); and the Cleveland Clinic Foundation-CCF-(Project 3). Project 1 is oriented toward cardiovascular applications, while projects 2 and 3 are oriented toward neurosurgical applications. The main objective of Project 1 is to develop an approach to assist patients in maintaining a constant level of stress while… more
Date: February 29, 2008
Creator: Pohost, Gerald M; Guthrie, Barton L & Steiner, Charles
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
open access

Dynamics of Adipocyte Turnover in Humans

Description: Obesity is increasing in an epidemic fashion in most countries and constitutes a public health problem by enhancing the risk for cardiovascular disease and metabolic disorders such as type 2 diabetes. Owing to the increase in obesity, life expectancy may start to decrease in developed countries for the first time in recent history. The factors determining fat mass in adult humans are not fully understood, but increased lipid storage in already developed fat cells is thought to be most important… more
Date: July 16, 2007
Creator: Spalding, K; Arner, E; Westermark, P; Bernard, S; Buchholz, B; Bergmann, O et al.
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
open access

A common allele on chromosome 9 associated with coronary heart disease

Description: Coronary heart disease (CHD) is a major cause of death in Western countries. Here we used genome-wide association scanning to identify a 58 kb interval on chromosome 9 that was consistently associated with CHD in six independent samples. The interval contains no annotated genes and is not associated with established CHD risk factors such as plasma lipoproteins, hypertension or diabetes. Homozygotes for the risk allele comprise 20-25% of Caucasians and have a {approx}30-40% increased risk of CHD… more
Date: March 1, 2007
Creator: McPherson, Ruth; Pertsemlidis, Alexander; Kavaslar, Nihan; Stewart, Alexandre; Roberts, Robert; Cox, David R. et al.
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
open access

In Vivo Characterization of Human APOA5 Haplotypes

Description: Increased plasma triglycerides concentrations are an independent risk factor for cardiovascular disease. Numerous studies support a reproducible genetic association between two minor haplotypes in the human apolipoprotein A5 gene (APOA5) and increased plasma triglyceride concentrations. We thus sought to investigate the effect of these minor haplotypes (APOA5*2 and APOA5*3) on ApoAV plasma levels through the precise insertion of single-copy intact APOA5 haplotypes at a targeted location in the … more
Date: October 1, 2006
Creator: Ahituv, Nadav; Akiyama, Jennifer; Chapman-Helleboid, Audrey; Fruchart, Jamila & Pennacchio, Len A.
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
open access

FISH CONSUMPTION, METHYLMERCURY, AND HUMAN HEART DISEASE.

Description: Environmental mercury continues to be of concern to public health advocates, both in the U.S. and abroad, and new research continues to be published. A recent analysis of potential health benefits of reduced mercury emissions has opened a new area of public health concern: adverse effects on the cardiovascular system, which could account for the bulk of the potential economic benefits. The authors were careful to include caveats about the uncertainties of such impacts, but they cited only a fra… more
Date: September 21, 2005
Creator: Lipfert, F. W. & Sullivan, T. M.
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
open access

Raman Spectroscopic Analysis of Biochemical Changes in Individual Triglyceride-Rich Lipoproteins in the Pre- and Postprandial State

Description: Individual triglyceride-rich lipoprotein (TGRL) particles derived from human volunteers are non-destructively analyzed by laser tweezers Raman microspectroscopy and information on their composition and distribution is obtained. The Raman signature of single optically trapped very low-density lipoproteins (VLDL), a subclass of TGRL, which play an important role in cardiovascular disease, exhibits distinct peaks associated with molecular vibrations of fatty acids, proteins, lipids, and structural… more
Date: September 13, 2004
Creator: Chan, J; Motton, D; Rutledge, J; Keim, N & Huser, T
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
open access

Use of tree-based models to identify subgroups and increase power to detect linkage to cardiovascular disease traits

Description: This article discusses the use of tree-based models to identify subgroups and increase power to detect linkage to cardiovascular disease traits.
Date: December 31, 2003
Creator: Costello, Tracy Jennifer; Swartz, Michael D.; Sabripour, Mahyar; Gu, Xiangjun; Sharma, Rishika & Etzel, Carol J.
Item Type: Refine your search to only Article
Partner: UNT College of Arts and Sciences
open access

Apolipoprotein AIF gene variant S347 is associated with increased risk of coronary heart disease and lower apolipoprotein AIV plasma concentrations

Description: The impact of common variants in the apolipoprotein gene cluster (APOC3-A4-A5) on prospective CHD risk was examined in healthy UK men. Of the 2808 men followed over nine years, 187 had a clinically defined CHD event. Examination of 9 single nucleotide polymorphisms (SNPs) in this group revealed that homozygotes for APOA4 S347 had significantly increased risk of CHD [Hazard ratio (HR) of 2.07 (95%CI 1.04-4.12)] while men homozygous for APOC3 1100T were protected (HR 0.28 (95%CI 0.09-0.87)). In s… more
Date: January 30, 2003
Creator: Wong, Wai-man R.; Hawe, Emma; Li, Lai K.; Miller, George J.; Nicaud, Viviane; Pennacchio, Len A. et al.
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
open access

Ethical and legal issues arising from complex genetic disorders. DOE final report

Description: The project analyzed the challenges raised by complex genetic disorders in genetic counselling, for clinical practice, for public health, for quality assurance, and for protection against discrimination. The research found that, in some settings, solutions created in the context of single gene disorders are more difficult to apply to complex disorders. In other settings, the single gene solutions actually backfired and created additional problems when applied to complex genetic disorders. The l… more
Date: October 9, 2002
Creator: Andrews, Lori
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
open access

PET IMAGING STUDIES IN DRUG ABUSE RESEARCH.

Description: There is overwhelming evidence that addiction is a disease of the brain (Leshner, 1997). Yet public perception that addiction is a reflection of moral weakness or a lack of willpower persists. The insidious consequence of this perception is that we lose sight of the fact that there are enormous medical consequences of addiction including the fact that a large fraction of the total deaths from cancer and heart disease are caused by smoking addiction. Ironically the medical school that educates p… more
Date: January 29, 2001
Creator: Fowler, J. S.; Volkow, N. D.; Ding, Y. S.; Logan, J. & Wang, G. J.
Item Type: Refine your search to only Book
Partner: UNT Libraries Government Documents Department
open access

Use of Reactor-Produced Radioisotopes for Prevention Restenosis After Angioplasty

Description: Coronary heart disease leads to myocardial infarction and is a major cause of death in the US. Myocardial infarctions result from atherosclerotic plaque deposits in the coronary arteries, reducing blood flow through these arteries which supply oxygen and nutrients to the heart muscle. The two major approaches for restoring adequate blood flow are coronary bypass graft surgery and coronary angioplasty. Angioplasty is a routinely used clinical procedure, where a deflated balloon attached to the e… more
Date: December 21, 1999
Creator: Knapp, F.F. & Pipes, D.W.
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
open access

Ernest Orlando Berkeley National Laboratory - Fundamental and applied research on lean premixed combustion

Description: Ernest Orland Lawrence Berkeley National Laboratory (Berkeley Lab) is the oldest of America's national laboratories and has been a leader in science and engineering technology for more than 65 years, serving as a powerful resource to meet Us national needs. As a multi-program Department of Energy laboratory, Berkeley Lab is dedicated to performing leading edge research in the biological, physical, materials, chemical, energy, environmental and computing sciences. Ernest Orlando Lawrence, the La… more
Date: July 7, 1999
Creator: Cheng, Robert K.
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
open access

Use of Rhenium-188 Liquid-Filled Balloons for Inhibition of Coronary Restenosis After PTCA - A New Opportunity for Nuclear Medicine

Description: Although the use of ionizing radiation for the treatment of benign lesions such as keloids has been available for nearly one hundred years, only recently have the cost effective benefits of such technology for the inhibition of arterial restenosis following controlled vessel damage from balloon angioplasty been fully realized. In particular, the use of balloons filled with solutions of beta-emitting radioisotopes for vessel irradiation provide the benefit of uniform vessel irradiation. Use of s… more
Date: May 13, 1999
Creator: Knapp, Jr., F. F.; Spencer, R. H. & Stabin, M.
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
open access

Heart pathology determination from electrocardiogram signals by application of deterministic chaos mathematics. CRADA final report

Description: It is well known that the electrical signals generated by the heart exhibit nonlinear, chaotic dynamics. A number of heart pathologies alter heartbeat dynamics and/or the electrical properties of the heart, which, in turn, alter electrocardiogram signals. Electrocardiogram techniques in common use for diagnosing pathologies have limited sensitivity and specificity. This leads to a relatively high misdiagnosis rate for ventricular fibrillation. It is also known that the linear analysis tools uti… more
Date: March 1, 1999
Creator: Clapp, N. E.; Hively, L. M. & Stickney, R. E.
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
open access

Experimental validation of superconducting quantum interference device sensors for electromagnetic scattering in geologic structures

Description: This is the final report of a one-year, Laboratory Directed Research and Development (LDRD) project at Los Alamos National Laboratory (LANL). This project has supported the collaborative development with Sandia National Laboratories (SNL) and the University of New Mexico (UNM) of two critical components for a hand-held low-field magnetic sensor based on superconducting quantum interference device (SQUID) sensor technology. The two components are a digital signal processing (DSP) algorithm for b… more
Date: October 1, 1997
Creator: Krauss, R.H. Jr.; Flynn, E. & Ruminer, P.
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
open access

BEST: Bilingual environmental science training: Grades 5--6

Description: This booklet is one of a series of bilingual guides to environmental-science learning activities for students to do at home. Lesson objectives, materials required, procedure, vocabulary, and subjects integrated into the lesson are described in English. A bilingual glossary, alphabetized by English entries, with Spanish equivalents and definitions in both English and Spanish, follows the lesson descriptions, and is itself followed by a bibliography of English-language references. This booklet in… more
Date: March 1, 1996
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
open access

A human factors engineering approach to biomedical decision making: A new role for automatic target recognizer technologies

Description: This report identifies the key features noted as requirements in the diagnostic decision-making process of Single Photon Emission Computed Tomography (SPECT) cardiac imaging. The report discusses the critical issues that create the basic system framework for design of an automatic target recognizer (ATR) algorithm prototype to support diagnosis of coronary artery disease. Candidate feature discovery algorithms that may form the basis of future work include Adaptive Resonance Theory and Bayesian… more
Date: January 1, 1995
Creator: Sobel, A. L.; Stalker, K. T. & Yee, A.
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
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