In vivo-detection, localization and measurement of radionuclides in man: a detection system for the localization amd measurement of small amounts of photon emitters. Progress report, March 1, 1981-October 31, 1981
Description: The design, construction, and testing of a photon detection system which will yield, simultaneously, information proportional to both the magnitude and location of sources of radioactivity are under investigation. The operating principle of the detector system, active collimation, allows spatial resolution by utilizing the crystal elements themselves as the collimating device; hence a greater counting efficiency is attainable. Two approaches have been tested thus far: in the first, the differences in characteristics of various crystals are utilized as the means of separating events occurring in each of five crystals viewed by a single phototube; in the second, smaller, single crystal/phototube elements are used in the array. Mathematical processing of the counts from the individual crystal elements is then employed in conjunction with their geometric relationship to develop both positional data and to quantify the amount of radioactivity. By utilizing crystal elements in an active collimation configuration and incorporating them in an array which permits these crystals to be alternately advanced and retracted in a programmed, ordered manner, a high degree of spatial resolution is achievable without compromising system sensitivity. The experiments include development of the optimal crystal configuration and the evolving of data processing techniques to translate detector response into precise source position information for localization or imaging purposes. Such a system could add another dimension in studies involving uptake, distribution, and retention of radionuclide labeled compounds because of its ability to actively track, in vivo, the distribution of these compounds. In addition, it should be possible to study, dynamically, the motion of organs, such as the heart or lungs, through which these compounds move. (ERB)
Date: November 1, 1981
Creator: Laurer, G. R.
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