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open access

Hedgehog signaling is involved in acquired resistance to KRASG12C inhibitors in lung cancer cells

Description: Article states that although KRASG12C inhibitors have shown promising activity in lung adenocarcinomas harboring KRASG12C, acquired resistance to these therapies eventually occurs in most patients. The authors report that the hedgehog signal is induced by KRASG12C inhibitors and mediates KRAS re-expression in cancer cells treated with a KRASG12C inhibitor.
Date: January 16, 2024
Creator: Lee, Chaeyoung; Yi, Jawoon; Park, Jihwan; Ahn, Byungyong; Won, Young-Wook; Jeon, JiHeung et al.
Partner: UNT College of Engineering
open access

Mesenchymal stem cells aligned and stretched in self-assembling peptide hydrogels

Description: Article describes how the presented research highlights a novel approach using fmoc-protected peptide hydrogels for the encapsulation and stretching of mesenchymal stem cells. This study utilized a custom mechanical stretching device with a PDMS chamber to stretch human mesenchymal stem cells encapsulated in Fmoc hydrogels.
Date: December 19, 2023
Creator: Fouladgar, Farzaneh; Moslabeh, Forough G. Z.; Kasani, Yashesh V.; Rogozinski, Nick; Torres, Marc; Ecker, Melanie et al.
Partner: UNT College of Engineering
open access

Surface Nanostructures Enhanced Biocompatibility and Osteoinductivity of laser-Additively Manufactured CoCrMo Alloys

Description: Article describes how cobalt–chromium–molybdenum (CoCrMo) alloys are widely used in orthopedic implants due to their excellent corrosion and wear resistance and superior mechanical properties. In this study, the authors prepared CoCrMo alloys with surface nanostructures of various aspect ratios (AR) using laser-directed energy deposition (L-DED) and biocorrosion.
Date: December 6, 2023
Creator: Man, Kun; Mazumder, Sangram; Dahotre, Narendra B. & Yang, Yong
Partner: UNT College of Engineering
open access

Detergent-Based Decellularization for Anisotropic Cardiac-Specific Extracellular Matrix Scaffold Generation

Description: Article describes how cell-derived extracellular matrix has become increasingly popular in tissue engineering applications due to its ability to provide tailored signals for desirable cellular responses. The objective of this study was to assess the efficacy of two detergent-based decellularization methods: a combination of ethylenediaminetetraacetic acid and sodium dodecyl sulfate and a combination of sodium deoxycholate and deoxyribonuclease.
Date: November 17, 2023
Creator: Chen, Te-An; Sharma, Dhavan; Jia, Wenkai; Ha, Donggi; Man, Kun; Zhang, Jianhua et al.
Partner: UNT College of Engineering
open access

Multifaceted Shape Memory Polymer Technology for Biomedical Application: Combining Self-Softening and Stretchability Properties

Description: Article describes how thiol-ene polymers are a promising class of biomaterials with a wide range of potential applications, including organs-on-a-chip, microfluidics, drug delivery, and wound healing. This study investigated the incorporation of di-acrylate chain extenders to improve the stretchability and conformability of those flexible thiol-ene polymers.
Date: October 25, 2023
Creator: Chitrakar, Chandani; Torres, Marc Anthony; Rocha-Flores, Pedro Emanuel; Hu, Qichan & Ecker, Melanie
Partner: UNT College of Engineering
open access

Nanotopographical Cues Tune the Therapeutic Potential of Extracellular Vesicles for the Treatment of Aged Skeletal Muscle Injuries

Description: Article describes how skeletal muscle regeneration relies on the tightly temporally regulated lineage progression of muscle stem/progenitor cells (MPCs) from activation to proliferation and finally, differentiation. The authors developed an engineering strategy to tune the therapeutic potential of EVs using nanotopographical cues.
Date: October 5, 2023
Creator: Wang, Kai; Frey, Nolan; Garcia, Andres C.; Man, Kun; Yang, Yong; Gualerzi, Alice et al.
Partner: UNT College of Engineering
open access

Suppression of the antitumoral activity of natural killer cells under indirect coculture with cancer-associated fibroblasts in a pancreatic TIME-on-chip model

Description: Article describes how recently, natural killer cells emerged as a treatment option for various solid tumors. The effect of activated pancreatic stellate cells on natural killer cell-mediated anticancer efficacy under three-dimensional coculture conditions was investigated.
Date: September 27, 2023
Creator: Kim, Hyun-Ah; Kim, Hyunsoo; Nam, Min-Kyung; Park, Jong Kook; Lee, Moo-Yeal; Chung, Seok et al.
Partner: UNT College of Engineering
open access

Harnessing nanofiber alignment and pore size to promote stem cell self-renewal and differentiation

Description: Article describes how stem cell therapy holds immense potential for regenerative medicine, but its applications are limited due to the loss of pluripotency during in vitro expansion. This study reveals that the arrangement of electrospun fibers aligns with the distribution and strength of the electric field through both experimentation and simulation.
Date: July 25, 2023
Creator: Wei, Qiang; Blake, Laurence; Liu, Jiafeng; Man, Kun; Liang, Cindy; Teoh, Alexandra et al.
Partner: UNT College of Engineering
open access

Light-Controlled Cell–Cell Assembly Using Photocaged Oligonucleotides

Description: Article asserts that while techniques that allow one to control the arrangement of cells and direct contact between different cell types have been developed that expand upon simple co-culture methods, specific control over heterojunctions that form between cells is not easily accomplished with current methods, such as 3D cell-printing. In this article, DNA-mediated cell interactions are combined with cell-compatible photolithographic approaches to control cell assembly.
Date: May 23, 2023
Creator: Mathis, Katelyn; Kohon, Agia Ibnat; Black, Stephen & Meckes, Brian
Partner: UNT College of Engineering
open access

A Review of Rehabilitative and Assistive Technologies for Upper-Body Exoskeletal Devices

Description: Authors state that this journal review article focuses on the use of assistive and rehabilitative exoskeletons as a new opportunity for individuals with diminished mobility. Overall, this article serves as a valuable resource for individuals working in the field of assistive and rehabilitative exoskeletons, providing insight into the state of the art and potential areas for improvement.
Date: April 20, 2023
Creator: Hays, Emilly; Slayton, Jack; Tejeda-Godinez, Gary; Carney, Emily; Cruz, Kobe; Exley, Trevor et al.
Partner: UNT College of Engineering
open access

A consensus statement on detection of hippocampal sharp wave ripples and differentiation from other fast oscillations

Description: Article suggests that common standards for recording, detection, and reporting for intracranial recordings in humans that suggest their role in episodic and semantic memory does not exist. Authors of the article outline the methodological challenges involved in detecting ripple events and offer practical recommendations to improve separation from other high-frequency oscillations, and argue that shared experimental, detection, and reporting standards will provide a solid foundation for future t… more
Date: October 12, 2022
Creator: Liu, Anli A.; Henin, Simon; Abbaspoor, Saman; Bragin, Anatol; Buffalo, Elizabeth A.; Farrell, Jordan S. et al.
Partner: UNT College of Engineering
open access

An approach for reliably identifying high-frequency oscillations and reducing false-positive detections

Description: Article states that high-frequency oscillation (HFO), classified as ripples (80-240 Hz) and fast ripples (240-500 Hz), is regarded as a promising biomarker of epilepsy. The authors presented an integrated, multi-layered procedure capable of automatically rejecting HFOs from a variety of common false positives, such as motion, background signals, and sharp transients.
Date: September 2, 2022
Creator: Zhou, Yufeng; You, Jing; Kumar, Udaya; Weiss, Shennan A.; Bragin, Anatol; Engel Jr., Jerome et al.
Partner: UNT College of Engineering
open access

Wearable airbag technology and machine learned models to mitigate falls after stroke

Description: Article discusses wearable airbag technology that has been designed to detect and mitigate fall impact. However, this technology has not been validated for the stroke population, so authors investigated whether population-specific training data and modeling parameters are required to pre-detect falls in a chronic stroke population.
Date: June 17, 2022
Creator: Botonis, Olivia K.; Harari, Yaar; Embry, Kyle R.; Mummidisetty, Chaithanya K.; Riopelle, David; Giffhorn, Matt et al.
Partner: UNT College of Engineering
open access

Current methods for fabricating 3D cardiac engineered constructs

Description: Article is a review highlighting the various cell types found in cardiac tissues and how they correspond with current advanced fabrication methods for creating cardiac engineered constructs.
Date: May 20, 2022
Creator: Rogozinski, Nicholas; Yanez, Apuleyo; Bhoi, Rahulkumar; Lee, Moo-Yeal & Yang, Huaxiao
Partner: UNT College of Engineering
open access

Nanocrown electrodes for parallel and robust intracellular recording of cardiomyocytes

Description: Article develops vertically-aligned nanocrown electrodes that are mechanically robust and achieve > 99% success rates in obtaining intracellular access through electroporation. This technology development provides an advancement towards establishing an iAP screening assay for preclinical evaluation of drug-induced arrhythmogenicity.
Date: April 26, 2022
Creator: Jahed, Zeinab; Yang, Yang; Tsai, Ching-Ting; Foster, Ethan P.; McGuire, Allister F.; Yang, Huaxiao et al.
Partner: UNT College of Engineering
open access

Flexible and Stretchable Bioelectronics

Description: Article reviewing several several flexible and stretchable materials used as substrate, stretchable electrical conduits and encapsulation, design modifications for stretchability, fabrication techniques, methods of signal transmission and monitoring, and the power sources for these stretchable bioelectronics. Ultimately, these bioelectronic devices can be used for wide range of applications from skin bioelectronics and biosensing devices, to neural implants for diagnostic or therapeutic purpose… more
Date: February 23, 2022
Creator: Chitrakar, Chandani; Hedrick, Eric; Adegoke, Lauren & Ecker, Melanie
Partner: UNT College of Engineering
open access

Pathological Targets for Treating Temporal Lobe Epilepsy: Discoveries From Microscale to Macroscale

Description: This review article summarizes the latest neuropathological discoveries at the molecular, cellular, and tissue levels involving both animal and patient studies, aiming to explore epileptogenesis and highlight new potential targets in the diagnosis and treatment of temporal lobe epilepsy (TLE).
Date: January 7, 2022
Creator: You, Jing; Huang, Haiyan; Chan, Clement T. Y. & Li, Lin
Partner: UNT College of Engineering
open access

Bioengineering Systems for Modulating Notch Signaling in Cardiovascular Development, Disease, and Regeneration

Description: This article is a review summarizing the significant roles of Notch signaling in individual cardiac cell types. It covers the bioengineering systems of microfluidics, hydrogel, spheroid, and 3D bioprinting and provides insights into ancillary supports of bioengineering systems, varied types of cardiovascular cells, and advanced characterization approaches in further refining Notch signaling in cardiovascular development, disease, and regeneration.
Date: September 30, 2021
Creator: Huerta Gomez, Angello; Joshi, Sanika; Yang, Yong; Tune, Johnathan D. & Zhao, Ming-Tao
Partner: University of North Texas
open access

Deep learning for peptide identification from metaproteomics datasets

Description: This article explores a proposed deep-learning-based algorithm called DeepFilter for improving peptide identifications from a collection of tandem mass spectra. The authors find that DeepFilter is believed to generalize properly to new, previously unseen peptide-spectrum-matches and can be readily applied in peptide identification from metaproteomics data.
Date: July 8, 2021
Creator: Feng, Shichao; Sterzenbach, Ryan & Guo, Xuan
Partner: UNT College of Engineering
open access

Differential Responses of Transplanted Stem Cells to Diseased Environment Unveiled by a Molecular NIR-II Cell Tracker

Description: This article develops a molecular cell tracker with a strong fluorescence signal in the second near-infrared (NIR-II) window (1,000-1,700 nm) for real-time monitoring of in vivo cell behaviors in both healthy and diseased animal models to address the issue of precisely and quantitatively evaluating the in vivo cell distribution, migration, and engraftment in stem cell therapy.
Date: June 9, 2021
Creator: Chen, Hao; Yang, Huaxiao; Zhang, Chen; Chen, Si; Zhao, Xin; Zhu, Mark et al.
Partner: UNT College of Engineering
open access

Using a microprocessor knee (C-Leg) with appropriate foot transitioned individuals with dysvascular transfemoral amputations to higher performance levels: a longitudinal randomized clinical trial

Description: Article evaluating whether advanced prostheses can provide better safety and performance capabilities to maintain and improve quality of life in individuals who are predominantly designated MFCL level K2. This study used a 13 month longitudinal clinical trial to determine the benefits of using a C-Leg and 1M10 foot in individuals at K2 level with transfemoral amputation due to vascular disease.
Date: May 25, 2021
Creator: Jayaraman, Chandrasekaran; Mummidisetty, Chaithanya K.; Albert, Mark; Lipschutz, Robert; Hoppe-Ludwig, Shenan; Mathur, Gayatri et al.
Partner: UNT College of Engineering
open access

Detection of Parkinson's Disease Through Automated Pupil Tracking of the Post-illumination Pupillary Response

Description: This article describes a system for pupil size estimation with a user interface to allow rapid adjustment of parameters and extraction of pupil parameters of interest in order to identify Parkinson's disease (PD) as early as possible.
Date: March 25, 2021
Creator: Tabashum, Thasina; Zaffer, Adnaan; Yousefzai, Raman; Colletta, Kalea; Jost, Mary Beth; Park, Youngsook et al.
Partner: UNT College of Engineering
open access

Overview of MMP-13 as a Promising Target for the Treatment of Osteoarthritis

Description: This article is a review that illustrates the involvement of MMP-13 in the initiation and progression of Osteoarthritis (OA) through the regulation of MMP-13 activity at the molecular and epigenetic levels, as well as the strategies that have been employed against MMP-13. The aim of this review is to identify MMP-13 as an attractive target for inhibitor development in the treatment of OA.
Date: February 9, 2021
Creator: Hu, Qichan & Ecker, Melanie
Partner: UNT College of Engineering
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