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Investigation on the Pulmonary Effects of Intermetallic Beryllium Compounds. Final Report, January 1, 1976-December 31, 1978

Description: The pulmonary response to the exposure to tantalum and niobium beryllide, and a copper beryllium alloy was investigated. The findings were compared to beryllium metal as positive control. 2.5 or 0.5 mg as beryllium were given to rats by intratracheal intubation. At 30, 60, and 90 days after exposure the response was similar with each material. There was inflammatory infiltrate by lymphocytes, macrophage accumulation, and beginning fibrosis of the terminal bronchioles. Epithelial hyperplasia occ… more
Date: unknown
Creator: Stemmer, K. L.
Partner: UNT Libraries Government Documents Department
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Rat mammary carcinogenesis following neutron- or x-radiation

Description: From effects of neutron irradiation upon cell function; Neuherberg, F. R. Germany (20 Oct 1973). Sprague-Dawley female rats, 61 to 63 days of age, were given a single dose of either 0.10, 0.40, 1.6, or 6.4 rads of 0.43-MeV neutrons, or 28, 56, or 85 rads of 250-kVp x rays, or no radiation in a single experiment. The interim results, either in terms of percent of rats with mammary neoplasia or mean number of mammary neoplasms per rat, at the end of 14 months after irradiation, indicate that 0.10… more
Date: January 1, 1973
Creator: Shellabarger, C. J.; Kellerer, A. M.; Rossi, H. H.; Goodman, L. J.; Brown, R. D.; Mills, R. E. et al.
Partner: UNT Libraries Government Documents Department
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Rational approach to patient exposure to radiation in the hospital

Description: During radiotherapy for the treatment of neoplasms the radiation dose needs to be selected with great care and the treatment needs to be carried out with a high degree of precision and accuracy for maximum results. Data are presented on the probability of tumor control of Hodgkin's disease and carcinoma of the supraglottis following radiation treatment. The x radiation dose to patients during various diagnostic radiographic examinations is discussed and several methods are suggested for dose re… more
Date: January 1, 1975
Creator: Lanzl, L. H. & Moser, F. L.
Partner: UNT Libraries Government Documents Department
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Deposition translocation, and effects of transuranic particles inhaled by experimental animals

Description: Inhalation exposure constitutes the most likely route of entrance for transuranics into the body. Cancer is the most likely consequence of exposure, but several thousand workers have been exposed during the last 30 yrs without, so far, evidence of exposure-related effects. Several soluble and insoluble transuranic compounds have been studied in rodents and dogs, either alone or combined with exposure to other materials (e.g., PuO/sub 2/--UO/sub 2/ fuel and Na). These studies have provided a wid… more
Date: January 1, 1977
Creator: Craig, D. K.; Ballou, J. E.; Dagle, G. E.; Mahlum, D. D.; Park, J. F.; Sanders, C. L. et al.
Partner: UNT Libraries Government Documents Department
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Uranium miner lung cancer study. Progress report, July 1, 1976--July 1, 1977

Description: This study was initiated in 1957 by the U.S. Public Health and many facets of this project are reaching final objectives. Many new studies have developed in the course of this study and will continue. The projects supported by the Energy Research and Development Administration are of utmost importance and consist of: collection of material from uranium miners known to have cancer of the lung into a tumor registry; manual on pulmonary cytology; regression study of sputum cytological findings in … more
Date: October 3, 1977
Creator: Saccomanno, G.
Partner: UNT Libraries Government Documents Department
open access

Respiratory tract carcinogenesis induced by radionuclides in the Syrian hamister

Description: Syrian hamsters were exposed to lung irradiation by various modalities that differed in degree of localization and the fraction of lung exposed. The animals were given alpha emitters under several exposure conditions: intratracheal (IT) instillation of /sup 210/Po and /sup 239/PuO/sub 2/-ZrO/sub 2/ microspheres; inhalation (INH) of /sup 238/ /sup 239/PuO/sub 2/-ZrO/sub 2/ particles; and/or intravenous (IV) injection of /sup 238/ /sup 239/PuO/sub 2/-ZrO/sub 2/ microspheres. Beta-emitting /sup 14… more
Date: January 1, 1979
Creator: Smith, D. M.; Thomas, R. G. & Anderson, E. C.
Partner: UNT Libraries Government Documents Department
open access

Respiratory tract tumors in Syrian hamsters following inhalation of Pu--ZrO/sub 2/ particles. [Comparison with incidence of lung tumors following intravenous injection of PuO/sub 2//ZrO/sub 2/ microspheres]

Description: Inhalation of radionuclide-bearing particles remains one of the most intensely pursued problems concerning the nuclear industry. This route of entry is generally accepted as the most probable, in case of human exposure, with ingestion being the other prominent source of concern. Many laboratory investigations, such as those reported here, continue to evaluate the possible consequences that may present health problems to the public domain. Syrian hamsters of both sexes received either inhaled (I… more
Date: January 1, 1979
Creator: Thomas, R. G. & Smith, D. M.
Partner: UNT Libraries Government Documents Department
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Assessment of the radiological impact of the inactive uranium-mill tailings at Shiprock, New Mexico

Description: Uranium-mill tailings at an inactive site near Shiprock, New Mexico, contain an estimated 950 curies (Ci) of /sup 226/Ra together with its radioactive daughters. A radiological survey was conducted at this site in February 1976. Decontamination work and tailings stabilization performed at the site since that time have greatly changed conditions there and little effort was applied to quantification of potential health effects in comparison to the earlier consideration of the site at Salt Lake Ci… more
Date: December 1, 1979
Creator: Haywood, F. F.; Goldsmith, W. A.; Lantz, P. M.; Fox, W. F.; Shinpaugh, W. H. & Hubbard, H. M., Jr.
Partner: UNT Libraries Government Documents Department
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Desferal (DFO) induced Ga-67 washout from normal tissue, tumor and abscess in experimental animals

Description: In the experimental animal, desferal (DFO) given intravenously washes out Ga-67 from all tissues. This effect is not uniform: blood activity is reduced very markedly, while liver activity is less affected. Maximal effect of DFO occurs if given close to the Ga-67 injection. When the time interval between the two is increased, the absolute amount of Ga-67 excreted in the urine in excess of the spontaneous excretion is reduced. Administration of DFO does not effect Ga-67 gastrointestinal excretion… more
Date: January 1, 1980
Creator: Oster, Z. H.; Som, P.; Atkins, H. L. & Brill, A. B.
Partner: UNT Libraries Government Documents Department
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Progress report on research on human genetics in Iceland

Description: Records of the Icelandic population are being used to investigate the possible inheritance of disabilities and diseases as well as other characteristics and the effect of environment on man. The progress report of research covers the period from 1977 to 1980. The investigation was begun in 1965 by the Genetical Committee of the University of Iceland and the materials used are demographic records from the year 1840 to present and various medical information. The records are being computerized an… more
Date: October 31, 1980
Partner: UNT Libraries Government Documents Department
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