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Neutron-induced mutation experiments. Progress report, March 1, 1975-- February 29, 1976

Description: The relative mutagenic effectiveness of neutrons of different energies were compared with x radiation in mice and Drosophila oogonia employing X-linked recessive lethal and specific locus mutation tests. The energies and doses used were 0.68 MeV, 2 MeV, and 6 MeV (250 and 500$sup 0$R), and 15 MeV (250, 500, and 1000$sup 0$R). The data thus far collected from the recessive lethal test indicate that 0.68 MeV neutrons have the highest RBE among the energies tested, followed by 6 and 2 MeV. The spe… more
Date: November 1, 1975
Creator: Abrahamson, S.
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
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INEL BNCT Program

Description: This Bulletin presents a summary of accomplishments and highlights in the Idaho National Engineering Laboratory's (INEL) Boron Neutron Capture Therapy (BNCT) Program for August 1991. This bulletin includes information on the brain tumor and melanoma research programs, Power Burst Facility (PBF) technical support and modifications, PBF operations, and updates to the animal data charts.
Date: August 1, 1991
Creator: Ackermann, A. L.
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
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INEL BNCT Program: Bulletin, Volume 5, No. 7

Description: This Bulletin presents a summary of accomplishments and highlights in the Idaho National Engineering Laboratory's (INEL) Boron Neutron Capture Therapy (BNCT) Program for June, 1991. This bulletin includes information on the brain tumor and melanoma research programs, Power Burst Facility (PBF) technical support and modifications, PBF operations, and animal data charts. Specific highlights include: final-dosage-form BSH samples were analyzed for purity, with the sample from Centronic Ltd the mos… more
Date: July 1, 1991
Creator: Ackermann, A. L.
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
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Optimizing the Delivery of Short-Lived Alpha Particle-Emitting Isotopes to Solid Tumors

Description: The underlying hypothesis of this project was that optimal alpha emitter-based radioimmunotherapy (RAIT) could be achieved by pairing the physical half-life of the radioisotope to the biological half-life of the targeting vehicle. The project had two specific aims. The first aim was to create and optimize the therapeutic efficacy of 211At-SAPS-C6.5 diabody conjugates. The second aim was to develop bispecific-targeting strategies that increase the specificity and efficacy of alpha-emitter-based … more
Date: November 24, 2004
Creator: Adams, Gregory P.
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
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In Vivo Characterization of Human APOA5 Haplotypes

Description: Increased plasma triglycerides concentrations are an independent risk factor for cardiovascular disease. Numerous studies support a reproducible genetic association between two minor haplotypes in the human apolipoprotein A5 gene (APOA5) and increased plasma triglyceride concentrations. We thus sought to investigate the effect of these minor haplotypes (APOA5*2 and APOA5*3) on ApoAV plasma levels through the precise insertion of single-copy intact APOA5 haplotypes at a targeted location in the … more
Date: October 1, 2006
Creator: Ahituv, Nadav; Akiyama, Jennifer; Chapman-Helleboid, Audrey; Fruchart, Jamila & Pennacchio, Len A.
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
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Medical Sequencing at the extremes of Human Body Mass

Description: Body weight is a quantitative trait with significantheritability in humans. To identify potential genetic contributors tothis phenotype, we resequenced the coding exons and splice junctions of58 genes in 379 obese and 378 lean individuals. Our 96Mb survey included21 genes associated with monogenic forms of obesity in humans or mice, aswell as 37 genes that function in body weight-related pathways. We foundthat the monogenic obesity-associated gene group was enriched for rarenonsynonymous varian… more
Date: September 1, 2006
Creator: Ahituv, Nadav; Kavaslar, Nihan; Schackwitz, Wendy; Ustaszewski,Anna; Martin, Joes; Hebert, Sybil et al.
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
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Deletion of ultraconserved elements yields viable mice

Description: Ultraconserved elements have been suggested to retainextended perfect sequence identity between the human, mouse, and ratgenomes due to essential functional properties. To investigate thenecessities of these elements in vivo, we removed four non-codingultraconserved elements (ranging in length from 222 to 731 base pairs)from the mouse genome. To maximize the likelihood of observing aphenotype, we chose to delete elements that function as enhancers in amouse transgenic assay and that are near ge… more
Date: July 15, 2007
Creator: Ahituv, Nadav; Zhu, Yiwen; Visel, Axel; Holt, Amy; Afzal, Veena; Pennacchio, Len A. et al.
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
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Tissue responses to low protracted doses of high let radiations or photons: Early and late damage relevant to radio-protective countermeasures

Description: Early and late murine tissue responses to single or fractionated low doses of heavy charged particles, fission-spectrum neutrons or gamma rays are considered. Damage to the hematopoietic system is emphasized, but results on acute lethality, host response to challenge with transplanted leukemia cells and life-shortening are presented. Low dose rates per fraction were used in some neutron experiments. Split-dose lethality studies (LD 50/30) with fission neutrons indicated greater accumulation of … more
Date: January 1, 1988
Creator: Ainsworth, E. J.; Afzal, S. M. J.; Crouse, D. A.; Hanson, W. R. & Fry, R. J. M.
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
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Cataract production in mice by heavy charged particles

Description: The cataractogenic effects of heavy charged particles have been evaluated in mice in relation to dose and ionization density (LET/sub infinity/). The study was undertaken due to the high potential for eye exposures to HZE particles among SPS personnel working in outer space. This has made it imperative that the relative biological effectiveness (RBE) in relation to LET/sub infinity/ for various particles be defined so that appropriate quality factors (Q) could be assigned for estimation of risk… more
Date: March 1, 1981
Creator: Ainsworth, E.H.; Jose, J.; Yang, V.V. & Barker, M.E.
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
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Temporal aspects of tumorigenic response to individual and mixed carcinogens. [Response of mouse skin to benzo(a)pyrene]

Description: Results are reported from experiments that involved either single or multiple doses of benzo(a)pyrene in mouse skin followed by prolonged observation. Preliminary results indicate linearity in dose and time and no evidence of recovery or enhancement for multiple doses of initiator given for extended periods of time. (auth)
Date: February 1, 1976
Creator: Albert, R. E. & Burns, F. J.
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
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Temporal aspects of tumorigenic response to individual and mixed carcinogens. Comprehensive progress report, June 1, 1975--May 31, 1978. [Mouse skin, rats, hamsters]

Description: The research proposed here is designed to obtain a better understanding of the temporal kinetics of tumor induction when one or more carcinogens are present simultaneously or sequentially for prolonged periods of time. Studies done to date under this contract have shown that carcinogenesis in mouse skin by polycyclic aromatic hydrocarbon carcinogens is consistent with the induction of dependent and autonomous cell transformations by the carcinogen followed by the conversion of autonomous tumor … more
Date: February 1, 1978
Creator: Albert, R. E.; Burns, F. J. & Altshuler, B.
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
open access

Temporal aspects of tumorigenic response to individual and mixed carcinogens. Progress report, October 1, 1978-September 30, 1979

Description: The research proposed here is designed to obtain a better understanding of the temporal kinetics of tumor induction when one or more carcinogens are present simultaneously or sequentially for prolonged periods of time. Studies done to date under this contract have shown that carcinogenesis in mouse skin by polycyclic aromatic hydrocarbon carcinogens is consistent with the induction of dependent and autonomous cell transformations by the carcinogen followed by the conversion of autonomous tumor … more
Date: June 1, 1979
Creator: Albert, R. E.; Burns, F. J. & Altshuler, B.
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
open access

Cellular oncogene expression following exposure of mice to {gamma}-rays

Description: We examined the effects of total body exposure of BCF1 mice to {gamma}-rays (300 cGy) in modulating expression of cellular oncogenes in both gut and liver tissues. We selected specific cellular oncogenes (c-fos, c-myc, c-src, and c-H-ras), based on their normal expression in liver and gut tissues from untreated mice. As early as 5 min. following whole body exposure of BCF1 mice to {gamma}-rays we detected induction of mRNA specific for c-src and c-H-ras in both liver and gut tissues. c-fos RNA … more
Date: June 12, 1991
Creator: Anderson, A. & Woloschak, G. E.
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
open access

Air blast studies with animals. Part II.

Description: Goats under Nembutal and mice were exposed in a shock tube modified to give longer-duration overpressures and equipped with ports for photography. Except for ear damage, displacement still seemed to be the major cause of injury in goats in the 4-foot section of the tube. However, it was found that mice were killed, apparently by pure blast, in a particular position in a particular type of side chamber attached to the higher-pressure, smaller-diameter, section of the tube. The relation between m… more
Date: April 1, 1961
Creator: Anderson, R. S.; Stemler, F. W. & Rogers, E. B.
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
open access

Monochromosomal hybrids for the analysis of the human genome

Description: In this research project the authors proposed to develop rodent/human hybrid cell lines each containing a single different human chromosome. The human chromosomes will be marked with Ecogpt and stably maintained by selection in the hybrid cells. The experimental approach to produce the proposed cell lines involve the following: they will first transfer a cloned selectable marker, Ecogpt (an E. coli gene for xanthine-guanine phosphoribosyltransferase: XGPRT) to normal diploid human cells using a… more
Date: January 1, 1990
Creator: Athwal, R. S.
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
open access

Monochromosomal hybrids for the analysis of the human genome

Description: We have already produced monochromosomal hybrids for 2/3 of the human genome and we have generated sufficient biological materials to complete the proposed panels of hybrid cell lines. We have developed experimental procedures to identify marked chromosomes in human cell lines prior to their transfer to rodent cells. This would eliminate redundancy in the production of monochromosomal hybrids and therefore help expedite completion of the hybrid cell panels. We have also developed a highly sensi… more
Date: January 1, 1992
Creator: Athwal, R. S.
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
open access

Monochromosomal hybrids for the analysis of the human genome. Technical report

Description: We have already produced monochromosomal hybrids for 2/3 of the human genome and we have generated sufficient biological materials to complete the proposed panels of hybrid cell lines. We have developed experimental procedures to identify marked chromosomes in human cell lines prior to their transfer to rodent cells. This would eliminate redundancy in the production of monochromosomal hybrids and therefore help expedite completion of the hybrid cell panels. We have also developed a highly sensi… more
Date: December 31, 1992
Creator: Athwal, R. S.
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
open access

Use of molecular hybridization to explore genetic relationships. Progress report, July 1, 1975--March 31, 1976. [Primates, mice, Drosophila]

Description: Progress is reported on the following research projects: distribution of rDNA in lymphocyte chromosomes of the gibbon; site of 55 DNA in chromosomes of the baboon; satellite associations and rDNA; polymorphisms in rDNA of mouse chromosomes; effect of prephotographing on hybridization; histone and immunoglobulin gene mapping; and rDNA magnification in Drosophila. (HLW)
Date: January 1, 1976
Creator: Atwood, K. C.
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
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