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IN-VIVO DIAGNOSIS OF CHEMICALLY INDUCED MELANOMA IN AN ANIMAL MODEL USING UV-VISIBLE AND NIR ELASTIC SCATTERING SPECTROSCOPY: PRELIMINARY TESTING.

Description: Elastic light scattering spectroscopy (ESS) has the potential to provide spectra that contain both morphological and chromophore information from tissue. We report on a preliminary study of this technique, with the hope of developing a method for diagnosis of highly-pigmented skin lesions, commonly associated with skin cancer. Four opossums were treated with dimethylbenz(a)anthracene to induce both malignant melanoma and benign pigmented lesions. Skin lesions were examined in vivo using both UV… more
Date: January 1, 2001
Creator: A'AMAR, C.; LEY, R. & AL, ET
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
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Genome-Wide Identification and 3D Modeling of Proteins involved in DNA Damage Recognition and Repair (Final Report)

Description: DNA Damage Recognition and Repair (DDR&R) proteins play a critical role in cellular responses to low-dose radiation and are associated with cancer. We have performed a systematic, genome-wide computational analysis of genomic data for human genes involved in the DDR&R process. The significant achievements of this project include: 1) Construction of the computational pipeline for searching DDR&R genes, building and validation of 3D models of proteins involved in DDR&R; 2) Functional and structur… more
Date: August 12, 2005
Creator: Abagyan, Ruben & An, Jianghong
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
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A High-Performance VME-Based Acquisition System for Positron Emission Mammography

Description: A prototype for a practical and economical breast imaging system for cancer detection is currently under development at Jefferson Lab. The latest advances in bright, fast, crystal scintillators, compact position-sensitive photomultipliers (PSPMT), and high-performance digitizing and readout electronics are being used to develop a compact imager based on Positron Emission Tomography (PET). To facilitate the performance demands of the detector as well as the high number of readout channels, the d… more
Date: November 1, 2001
Creator: Abbott, D.J.; Weisenberger, A.; Majewski, S.; Kieper, D.; Kross, B.; Popov, V. et al.
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
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Health effects models for nuclear power plant accident consequence analysis: Modifications of models resulting from recent reports on health effects of ionizing radiation

Description: The Nuclear Regulatory Commission has sponsored several studies to identify and quantify the potential health effects of accidental releases of radionuclides from nuclear power plants. The most recent health effects models resulting from these efforts were published in two reports, NUREG/CR-4214, Rev. 1, Part 1 (1990) and Part 2 (1989). Several major health effects reports have been published recently that may impact the health effects models presented in these reports. This addendum to the Par… more
Date: August 1, 1991
Creator: Abrahamson, S.; Bender, M. A.; Boecker, B. B.; Scott, B. R. & Gilbert, E. S.
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
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Health effects models for nuclear power plant accident consequence analysis: Low LET radiation: Part 2, Scientific bases for health effects models

Description: This report provides dose-response models intended to be used in estimating the radiological health effects of nuclear power plant accidents. Models of early and continuing effects, cancers and thyroid nodules, and genetic effects are provided. Two-parameter Weibull hazard functions are recommended for estimating the risks of early and continuing health effects. Three potentially lethal early effects -- the hematopoietic, pulmonary and gastrointestinal syndromes -- are considered. Linear and li… more
Date: May 1, 1989
Creator: Abrahamson, S.; Bender, M.; Book, S.; Buncher, C.; Denniston, C.; Gilbert, E. et al.
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
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INEL BNCT Program

Description: This Bulletin presents a summary of accomplishments and highlights in the Idaho National Engineering Laboratory's (INEL) Boron Neutron Capture Therapy (BNCT) Program for August 1991. This bulletin includes information on the brain tumor and melanoma research programs, Power Burst Facility (PBF) technical support and modifications, PBF operations, and updates to the animal data charts.
Date: August 1, 1991
Creator: Ackermann, A. L.
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
open access

INEL BNCT Program: Bulletin, Volume 5, No. 7

Description: This Bulletin presents a summary of accomplishments and highlights in the Idaho National Engineering Laboratory's (INEL) Boron Neutron Capture Therapy (BNCT) Program for June, 1991. This bulletin includes information on the brain tumor and melanoma research programs, Power Burst Facility (PBF) technical support and modifications, PBF operations, and animal data charts. Specific highlights include: final-dosage-form BSH samples were analyzed for purity, with the sample from Centronic Ltd the mos… more
Date: July 1, 1991
Creator: Ackermann, A. L.
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
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INEL BNCT Program: Volume 5, No. 9

Description: This Bulletin presents a summary of accomplishments and highlights of the Idaho National Engineering Laboratory's (INEL) Boron Neutron Capture Therapy (BNCT) Program for September 1991. This bulletin includes information on the brain tumor and melanoma research programs, Power Burst Facility (PBF) technical support and modifications, PBF operations, and updates to the animal data charts.
Date: January 1, 1991
Creator: Ackermann, A. L.
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
open access

INEL BNCT Program: Volume 5, No. 9. Bulletin, September 1991

Description: This Bulletin presents a summary of accomplishments and highlights of the Idaho National Engineering Laboratory`s (INEL) Boron Neutron Capture Therapy (BNCT) Program for September 1991. This bulletin includes information on the brain tumor and melanoma research programs, Power Burst Facility (PBF) technical support and modifications, PBF operations, and updates to the animal data charts.
Date: December 31, 1991
Creator: Ackermann, A. L.
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
open access

Power Burst Facility/Boron Neutron Capture Therapy Program for cancer treatment

Description: This bulletin discusses activities during this reporting period in the areas of: supporting technology development; large animal model studies; melanoma project; human studies; stability, pharmacology, and toxicology of drugs; and PBF technical support. (FL)
Date: October 1, 1990
Creator: Ackermann, A. L.
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
open access

Power Burst Facility/Boron Neutron Capture Therapy program for cancer treatment, Volume 4, No. 7

Description: This report discusses the monthly progress of the Power Burst Facility/Boron Neutron Capture Therapy (PBF/BNLT) program for cancer treatment. Highlights of the PBF/BNCT Program during July 1990 include progress within the areas of: Gross boron analysis in tissue, blood, and urine; noninvasive boron quantitative determination; analytical radiation transport and interaction modeling for BNCT; large animal model studies; neutron source and facility preparation; administration and common support an… more
Date: July 1, 1990
Creator: Ackermann, A. L.
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
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Power Burst Facility/Boron Neutron Capture Therapy Program for cancer treatment

Description: This monthly bulletin describes activities in the following project areas during this reporting period: supporting technology development, large animal model studies, neutron source and facility preparation, administration and common support, and PBF operations. (FI)
Date: September 1, 1990
Creator: Ackermann, A.L. (ed.) & Dorn, R.V. III.
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
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Power Burst Facility/Boron Neutron Capture Therapy Program for cancer treatment

Description: This report discusses monthly progress in the Power Boron Facility/Boron Neutron Capture Therapy (PBF/BNCT) Program for Cancer Treatment. Highlights of the PBF/BNCT Program during August 1990 include progress within the areas of: Gross Boron Analysis in Tissue, Blood, and Urine, boron microscopic (subcellular) analytical development, noninvasive boron quantitative determination, analytical radiation transport and interaction modeling for BNCT, large animal model studies, neutron source and faci… more
Date: August 1, 1990
Creator: Ackermann, A.L. (ed.) & Dorn, R.V. III.
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
open access

Evaluation of cancer incidence among employees at the Los Alamos National Laboratory

Description: As part of the National Plutonium Workers Study, cancer incidence for 1969 to 1978 among employees of the Los Alamos National Laboratory was investigated. Incident cancers were identified by a computer match of the Los Alamos employed roster against New Mexico Tumor Registry files. The resulting numbers of total and site-specific cancers were compared to the numbers expected based on incidence rates for the State of New Mexico, specific for age, sex, ethnicity, and calendar period. For Anglo ma… more
Date: January 1, 1983
Creator: Acquavella, J. F.; Wilkinson, G. S.; Wiggs, L. D.; Tietjen, G. L. & Key, C. R.
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
open access

Optimizing the Delivery of Short-Lived Alpha Particle-Emitting Isotopes to Solid Tumors

Description: The underlying hypothesis of this project was that optimal alpha emitter-based radioimmunotherapy (RAIT) could be achieved by pairing the physical half-life of the radioisotope to the biological half-life of the targeting vehicle. The project had two specific aims. The first aim was to create and optimize the therapeutic efficacy of 211At-SAPS-C6.5 diabody conjugates. The second aim was to develop bispecific-targeting strategies that increase the specificity and efficacy of alpha-emitter-based … more
Date: November 24, 2004
Creator: Adams, Gregory P.
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
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Medical status of Marshallese accidentally exposed to 1954 Bravo fallout radiation: January 1980-December 1982

Description: This report updates, for 1980 through 1982, the results of continuing medical surveillance of a Marshallese population accidentally exposed to radioactive fallout in March 1954. The originally exposed Marshallese population comprised 64 persons on Rongelap Atoll who each received, on the average, an estimated 190 rads of absorbed external gamma radiation, 18 on Ailingnae Atoll who received 110 rads, and 159 on Utirik who received 11 rads. There were, in addition, 3 persons in utero on Rongelap,… more
Date: January 1, 1984
Creator: Adams, W. H.; Harper, J. A.; Rittmaster, R. S.; Heotis, P. M. & Scott, W. A.
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
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Late biological effects from internal and external exposure

Description: Information on late biological effects of radiation was obtained from the long-term medical followup of a small population of Marshallese accidentally exposed to radioactive fallout from a thermonuclear test in 1954. Endocrine data are compatible with a sequence of nonstochastic radiation effects. The ingestion of radioisotopes of iodine produced clinical thyroid hypofunction in children, biochemical evidence of thyroid dysfunction in some adults, thyroid adenomatous module formation, and, as a… more
Date: January 1, 1985
Creator: Adams, W.H.
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
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Harvard-MIT research program in short-lived radiopharmaceuticals. Technical progress report, 1991

Description: This report presents research on radiopharmaceuticals. The following topics are discussed: antibody labeling with positron-emitting radionuclides; antibody modification for radioimmune imaging; labeling antibodies; evaluation of technetium acetlyacetonates as potential cerebral blood flow agents; and studies in technetium chemistry. (CBS)
Date: December 31, 1991
Creator: Adelstein, S. J.
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
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Harvard-MIT research program in short-lived radiopharmaceuticals

Description: This report presents research on radiopharmaceuticals. The following topics are discussed: antibody labeling with positron-emitting radionuclides; antibody modification for radioimmune imaging; labeling antibodies; evaluation of technetium acetlyacetonates as potential cerebral blood flow agents; and studies in technetium chemistry. (CBS)
Date: January 1, 1991
Creator: Adelstein, S.J.
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
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Development and radiotherapeutic application of /sup 211/At-labeled radiopharmaceuticals. Progress report, March 1, 1981-February 28, 1982

Description: This project is concerned with developing the potential of alpha-emitting radionuclides as agents for radiotherapy. Alpha-emitters seem ideally suited for his application because their high linear energy transfer and short range permit the deposition of considerable energy in a very small volume of tissue. Unlike the beta particles of /sup 131/I which have a range of about 1 to 2 mm in tissue, 5 to 7 MeV alpha particles would traverse only a few cell diameters. Among the available alpha-emitter… more
Date: January 1, 1981
Creator: Adelstein, S.J.; Zalutsky, M. & Bloomer, W.
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
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The Ghanaian Approach to the Development of an Effective Waste Management Regime

Description: In Ghana, radioactive waste is generated mainly from spent sealed sources, various nuclear applications--diagnostic and therapeutic procedures in medicine and measurement and processing techniques in industry. The radionuclide composition in the waste arising from industry, research and teaching includes 14C, 137Cs, 60Co, 241Am, 3H, 32P, 125I, 192Ir, 131I, 99m Tc, 35S and 90Sr. Ghana is strengthening its radioactive waste management infrastructure, which include the development of a legal frame… more
Date: February 24, 2003
Creator: Adu, P. S.; Gbadago, J. K. & Glover, E. T.
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
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Tissue responses to low protracted doses of high let radiations or photons: Early and late damage relevant to radio-protective countermeasures

Description: Early and late murine tissue responses to single or fractionated low doses of heavy charged particles, fission-spectrum neutrons or gamma rays are considered. Damage to the hematopoietic system is emphasized, but results on acute lethality, host response to challenge with transplanted leukemia cells and life-shortening are presented. Low dose rates per fraction were used in some neutron experiments. Split-dose lethality studies (LD 50/30) with fission neutrons indicated greater accumulation of … more
Date: January 1, 1988
Creator: Ainsworth, E. J.; Afzal, S. M. J.; Crouse, D. A.; Hanson, W. R. & Fry, R. J. M.
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
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Co-Funding for the Conference on Magnetic Resonance in Biological Systems

Description: The XXIst International Conference on Magnetic Resonance in Biological Systems (ICMRBS 2005), '60th anniversary of the discovery of Nuclear Magnetic Resonance,' was held between 16 and 21 January 2005 in Hyderabad, India. The meeting focused on a broad range of magnetic resonance methods as applied to studies of biological processes related to human health. The biennial ICMRBS has become the major venue for discussion of advances in nuclear and electron magnetic resonance (NMR & EMR/EPR) studie… more
Date: October 1, 2008
Creator: Alan McLaughlin, Ph.D., Director, Division of Applied Science & Technology, NIBIB, NIH
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
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