Laser desorption/ionization mass spectrometry for direct profiling and imaging of small molecules from raw biological materials
Description:
Matrix-assisted laser desorption/ionization(MALDI) mass spectrometry(MS) has been widely used for analysis of biological molecules, especially macromolecules such as proteins. However, MALDI MS has a problem in small molecule (less than 1 kDa) analysis because of the signal saturation by organic matrixes in the low mass region. In imaging MS (IMS), inhomogeneous surface formation due to the co-crystallization process by organic MALDI matrixes limits the spatial resolution of the mass spectral i…
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Date:
May 15, 2008
Creator:
Cha, Sangwon
Partner:
UNT Libraries Government Documents Department