In-Vitro and in-Vivo Characterization of Ruthenium-Bleomycin Compared to Cobalt- and Copper-Bleomycin
Description:
Bleomycin (BLM) has undergone extensive investigation both as a cancer chemotherapeutic agent, and as a carrier for radionuclides for tumor imaging. The available methods or the radionuclides used, however, have had limited effectiveness. Although labeling of BLM with /sup 103/Ru has been reported earlier, we carried out a study to develop a more reproducible method of labeling particularly for use with Brookhaven Linac Isotope Producer produced /sup 97/Ru. Ruthenium-97 has favorable physical p…
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Date:
January 1, 1986
Creator:
Shao, H. S.; Meinken, G. E.; Srivastava, S. C.; Slosman, D.; Sacker, D. F.; Som, P. et al.
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