Search Results

Testing gene-environment interactions for rare and/or common variants in sequencing association studies

Description: Article describes study in which novel approaches to test the effects of gene-environment (GE) interactions of rare and/or common risk, and/or protective variants in sequencing association studies were developed.
Date: March 10, 2020
Creator: Zhao, Zihan; Zhang, Jianjun; Sha, Qiuying & Hao, Han
Partner: UNT College of Arts and Sciences

A gene based approach to test genetic association based on an optimally weighted combination of multiple traits

Description: In this article, the authors propose a statistical method by Testing an Optimally Weighted Combination of Multiple traits (TOW-CM) to test the association between multiple traits and multiple variants in a genomic region (a gene or pathway). They investigate the performance of the proposed method through extensive simulation studies. Their simulation studies show that the proposed method has correct type I error rates and is either the most powerful test or comparable with the most powerful tests. Additionally, they illustrate the usefulness of TOW-CM based on a COPDGene study.
Date: August 9, 2019
Creator: Zhang, Jianjun; Sha, Qiuying; Liu, Guanfu & Wang, Xuexia
Partner: UNT College of Arts and Sciences

Identification and characterization of a core set of ROS wave‐associated transcripts involved in the systemic acquired acclimation response of Arabidopsis to excess light

Description: Article reveal that the systemic transcriptomic response of plants to excess light stress is extensive in the context of systemic acquired acclimation and involves an early (2 min) and transient stage of transcript expression that includes thousands of genes.
Date: December 6, 2018
Creator: Zandalinas, Sara I.; Sengupta, Soham; Burks, David; Azad, Rajeev K. & Mittler, Ron
Partner: UNT College of Arts and Sciences

Local and Systemic Metabolic Responses during Light-Induced Rapid Systemic Signaling

Description: This article reports that local application of light stress to one rosette leaf of bolting Arabidopsis (Arabidopsis thaliana) plants resulted in a metabolic response that encompassed local, systemic and transport tissues, demonstrating a high degree of physical and metabolic continuity between different tissues throughout the plant.
Date: December 2018
Creator: Choudhury, Feroza K.; Devireddy, Amith R.; Azad, Rajeev K.; Shulaev, Vladimir & Mittler, Ron
Partner: UNT College of Arts and Sciences

GAW20: methods and strategies for the new frontiers of epigenetics and pharmacogenomics

Description: Article presents an overview of the data sets and the contributions analyzing data related to human lipid-related phenotypes, DNA methylation, and single-nucleotide markers in a study involving a pharmaceutical intervention.
Date: September 17, 2018
Creator: Tintle, Nathan L.; Fardo, David W.; de Andrade, Mariza; Aslibekyan, Stella; Bailey, Julia N.; Bermejo, Justo Lorenzo et al.
Partner: UNT College of Arts and Sciences

Methods and results from the genome-wide association group at Genetic Analysis Workshop 20

Description: This article summarizes the contributions from the Genome-wide Association Study group (GWAS group) of the GAW20. The GWAS group contributions focused on topics such as association tests, phenotype imputation, and application of empirical kinships. This summary article reports on promising statistical approaches and findings of the members of the GWAS group applied on real and simulated data which encompass the current topics of epigenetic and pharmacogenomics.
Date: September 17, 2018
Creator: Wang, Xuexia; Boekstegers, Felix & Brinster, Regina
Partner: University of North Texas

Existence of Solutions for Sublinear Equations on Exterior Domains

Description: This article proves the existence of an infinite number of radial solutions of Δu+K(r)ƒ(u) = 0, one with exactly n zeros for each nonnegative integer n on the exterior of the ball of radius R > 0, Bʀ, centered at the origin in ℝᴺ with u = 0 on ∂Bʀ and limᵣ→∞u(r) = 0 where N > 2, f is odd with ƒ < 0 on (0; β), ƒ > 0 on (β;∞), ƒ(u) ~ uᵖ with 0 < p < 1 for large u and K(r) ~ r-α with 0 < α < 2 for large r.
Date: October 10, 2017
Creator: Iaia, Joseph A.
Partner: UNT College of Arts and Sciences

Existence and Nonexistence of Solutions for Sublinear Equations on Exterior Domains

Description: This article studies radial solutions of Δu + K(r)ƒ(u) = 0 on the exterior of the ball of radius R > 0, BR, centered at the origin in ℝN with u = 0 on @BR where ƒ is odd with ƒ < 0 on (0; β), ƒ > 0 on (β;∞), f(u) ~ uᵖ with 0 < p < 1 for large u and K(r) ~ r⁻ᵅ for large r.
Date: December 29, 2016
Creator: Iaia, Joseph A.
Partner: UNT College of Arts and Sciences

Badly approximable points on self-affine sponges and the lower Assouad dimension

Description: This article highlights a connection between Diophantine approximation and the lower Assouad dimension by using information about the latter to show that the Hausdorff dimension of the set of badly approximable points that lie in certain non-conformal fractals, known as self-affine sponges, is bounded below by the dynamical dimension of these fractals. The results, which are the first to advance beyond the conformal setting, encompass both the case of Sierpiński sponges/carpets (also known as Bedford–McMullen sponges/carpets) and the case of Barański carpets.
Date: June 20, 2017
Creator: Das, Tushar; Fishman, Lior; Simmons, David & Urbański, Mariusz
Partner: UNT College of Arts and Sciences

Environmental vibrios represent a source of antagonistic compounds that inhibit pathogenic Vibrio cholerae and Vibrio parahaemolyticus strains

Description: This article predicts that marine-derived bacteria should inhibit Vibrio pathogens and may be a source of unique antibiotic compounds.
Date: March 10, 2017
Creator: Burks, David J.; Norris, Stephen; Kauffman, Kathryn M.; Joy, Abigail; Arevalo, Philip; Azad, Rajeev K. et al.
Partner: UNT College of Arts and Sciences

Interactions between mitoNEET and NAF-1 in cells

Description: This article uses yeast two-hybrid to demonstrate through vivo bimolecular fluorescence complementation (BiFC), direct coupling analysis (DCA), RNA-sequencing, ROS and iron imaging, and single and double shRNA lines with suppressed mNT, NAF-1 and mNT/NAF-1 expression, that mNT and NAF-1 directly interact in mammalian cells and could function in the same cellular pathway.
Date: April 20, 2017
Creator: Karmi, Ola; Holt, Sarah H.; Song, Luhua; Tamir, Sagi; Luo, Yuting; Bai, Fang et al.
Partner: UNT College of Arts and Sciences