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Naloxone Potentiation of Epinephrine Induced Vasoconstriction in Canine Skeletal Muscle Arteries

Description: Naloxone (NX) potentiated epinephrine (EPI) induced submaximal vasoconstriction in canine renal and skeletal muscle arterial segments, yet had no vasoconstrictor action alone. Developed tension generated in-vitro by 4 x 1mm. O.D. rings from 1st degree branches of canine femoral arteries was expressed as % of KCI induced maximum response. NX (10^-5 M) potentiated EPI induced submaximal contractions (34.2%) significantly more than contractions induced by norepinephrine, phenylephrine, lofexidine,… more
Date: August 1992
Creator: Stoll, Scott Thomas
Partner: UNT Libraries
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