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Ocular Hypotensive Effect of the α2-Adrenergic Agonist, Lofexidine

Description: A selective a2-adrenergic agonist, lofexidine, significantly reduced intraocular pressure (lOP) in intact ocular normotensive NZW rabbits, producing a differential dose-dependent decrease in IOP in'the ipsilateral and contralateral eye. Contralateral IOP reduction was most observable at low doses. Unilateral superior cervical ganglionectomy and extraocular muscle excision studies were undertaken to elucidate the factors influencing differential IOP reduction by lofexidine. Similar significant c… more
Date: August 1989
Creator: Tran, Tung Vu
Partner: UNT Libraries
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