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Characterization of Tolerance and Cross-tolerance between Noncompetitive N-methyl-D-aspartate (NMDA) Antagonists in Rats Trained to Self-administer Ketamine

Description: Ketamine and phencyclidine (PCP) are noncompetitive antagonists of the N-methyl-D-aspartate (NMDA) type of ligand-gated glutamate receptors. Both agents have high abuse liability, and may produce dependence. Tolerance to the reinforcing effects of drugs of abuse is widely regarded as a key component of the dependence process. Therefore, the present study was conducted to examine whether tolerance develops to the reinforcing effects of ketamine, and whether PCP and dizocilpine, a noncompetitive NMDA antagonist with negligible abuse liability, produce cross-tolerance to the reinforcing effects of ketamine. Further, identification of the neural mechanisms that underlie tolerance to the reinforcing effects of drugs may yield information regarding drug dependence.
Date: December 1995
Creator: Ward, Amie S. (Amie Sue)
Partner: UNT Libraries

Speaking for America ... Spencer Tracy.

Description: Black and white photograph of Spencer Tracy on a blue background. Text box contains a quote celebrating cultural diversity and tolerance in the armed forces and encouraging all Americans to follow their example after the war.
Date: unknown
Creator: Scholastic Magazines, Inc.
Partner: UNT Libraries Government Documents Department