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Neuronal Network Analyses in vitro of Acute Individual and Combined Responses to Fluoxetine and Ethanol

Description: Embryonic murine neuronal networks cultured on microelectrode arrays were used to quantify acute electrophysiological effects of fluoxetine and ethanol. Spontaneously active frontal cortex cultures showed highly repeatable, dose-dependent sensitivities to both compounds. Cultures began to respond to fluoxetine at 3 µM and were shut off at 10-16 µM. EC50s mean ± S.D. for spike and burst rates were 4.1 ± 1.5 µM and 4.5 ± 1.1 µM (n=14). The fluoxetine inhibition was reversible and without effect on action potential wave shapes. Ethanol showed initial inhibition at 20 mM, with spike and burst rate EC50s at 52.0 ± 17.4 mM and 56.0 ± 17.0 mM (n=15). Ethanol concentrations above 100 -140 mM led to cessation of activity. Although ethanol did not change the shape and amplitude of action potentials, unit specific effects were found. The combined application of ethanol and fluoxetine was additive. Ethanol did not potentiate the effect of fluoxetine.
Date: August 2002
Creator: Xia,Yun
Partner: UNT Libraries

Characterizing Spontaneous Neurophysiological Activity with Measures of Statistical Serial Dependence: a Summary Statistic and an Extension of the Joint Interval Histogram

Description: Two measures which indicate statistical serial dependence were evaluated. The n-dimensional Average Stored Information index (ndASI) is a measure of conditional information, which compares the entropies of higher order conditional distributions to estimate average statistical serial dependence. The generalized ranked joint interval histogram (RJIH-o) is a new nonparametric graphical analysis method. It extends the joint interval histogram by depicting longer interval sequences and can be interpereted precisely analagously to the joint interval histogram. The generalized ranked joint interval histogram correctly represents independence in a Poisson process model and statistical serial dependence in a directionally reinforced Markov model. The generalized ranked joint interval histogram correctly depicts the underlying periodic and strange attractors in a standard map model. Both measures can be used to effectively analyze interspike interval sequences from spontaneous neurophsyiological activity effectively.
Date: August 1994
Creator: Weil, Jon C. (Jon Christopher)
Partner: UNT Libraries

Brain topography of leadership: neurophysiological correlates of the leadership opinion questionnaire

Description: Laboratory research was performed to understand leadership by attempting to link EEG baseline frequency patterns with data from the Leadership Opinion Questionnaire (LOQ) assessment survey. Research began with 293 right-handed males, 18-26 years old, who completed the LOQ. Based on their scores, 61 subjects grouped by the Ohio State Leadership Quadrants, were tested using brain-mapping technology.
Date: December 1995
Creator: Dukes, David Jefferson
Partner: UNT Libraries

Ultrastructural characteristics of cultured embryonic mouse olfactory epithelial and bulb cells

Description: This laboratory is involved in physiological and histochemical studies of olfactory tissue grown in cell culture in an attempt to create an in vitro model of the olfactory system. The present study is an in-depth ultrastructural study of the morphology of cultured olfactory cells to determine the extent of similarities and differences between cultured tissues and the intact olfactory system in vivo.
Date: August 1991
Creator: Guo, Luzhi
Partner: UNT Libraries