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Application of Cultured Neuronal Networks for Use as Biological Sensors in Water Toxicology and Lipid Signaling.

Description: This dissertation research explored the capabilities of neuronal networks grown on substrate integrated microelectrode arrays in vitro to be applied to toxicological research and lipid signaling. Chapter 1 details the effects of chlorine on neuronal network spontaneous electrical activity and pharmacological sensitivity. This study demonstrates that neuronal networks can maintain baseline spontaneous activity, and respond normally to pharmacological manipulations in the present of three times… more
Access: Restricted to the UNT Community Members at a UNT Libraries Location.
Date: August 2004
Creator: Dian, Emese Emöke
Item Type: Refine your search to only Thesis or Dissertation
Partner: UNT Libraries
open access

Optimization of Cell Culture Procedures for Growing Neural Networks on Microelectrode Arrays

Description: This thesis describes the development of an optimized method for culturing dissociated, monolayer neuronal networks from murine frontal cortex and midbrain. It is presented as a guidebook for use by cell culture specialists and laboratory personnel who require updated and complete procedures for use with microelectrode array (MEA) recording technology. Specific cell culture protocols, contamination prevention and control, as well common problems encountered within the cell culture facility, are… more
Date: December 2007
Creator: Santa Maria, Cara L.
Item Type: Refine your search to only Thesis or Dissertation
Partner: UNT Libraries
open access

Concentration-dependent Effects of D-Methylphenidate on Frontal Cortex and Spinal Cord Networks in vitro

Description: Spontaneously active frontal cortex and spinal cord networks grown on microelectrode arrays were used to study effects of D-methylphenidate. These central nervous system tissues have relatively low concentrations of dopaminergic and noradrenergic neurons compared to the richly populated loci, yet exhibit similar neurophysiological responses to methylphenidate. The spontaneous spike activity of both tissues was inhibited in a concentration-dependent manner by serial additions of 1-500 µM methylp… more
Date: December 2004
Creator: Miller, Benjamin R.
Item Type: Refine your search to only Thesis or Dissertation
Partner: UNT Libraries
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