Teratogenic and Mutagenic Potential of Triethylenemelamine, Ethyl Methanesulfonate, and N-Ethyl-N-Nitrosourea for Causing Fetal Anomalies in Mus Musculus
Description: In five separate experiments, weight-adjusted doses of TEM, EMS, and ENU were injected intraperitoneally into twelve week-old female mice six hours after mating. On day seventeen of gestation, the females were sacrificed and their uterine contents were examined. The effect of each agent was determined by its ability to cause malformations and death to the developing embryos. All treatment groups showed statistically significant elevated levels of malformations in comparison to their corresponding control groups. The reproductive damage induced in these experiments cannot be singularly attributed to teratogenesis or mutagenesis but a combination of the two.
Date: December 1987
Creator: Gans, Murry J. (Murry Joe)
Partner: UNT Libraries