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Extensively Drug-Resistant Tuberculosis (XDR-TB): Emerging Public Health Threats and Quarantine and Isolation

Description: This report the international saga of Andrew Speaker, a traveler thought to have XDR-TB, a drug-resistant form of tuberculosis, placed a spotlight on existing mechanisms to contain contagious disease threats and raised numerous legal and public health issues. It also discusses the application of various public health measures available to contain an emerging public health threat posed by an individual who ignores medical advice and attempts to board an airplane or take other forms of public transportation.
Date: November 26, 2010
Creator: Swendiman, Kathleen S. & Jones, Nancy Lee
Partner: UNT Libraries Government Documents Department

The Global Fund to Fight AIDS, Tuberculosis, and Malaria: U.S. Contributions and Issues for Congress

Description: The Global Fund to Fight AIDS, Tuberculosis, and Malaria (Global Fund, or the Fund) was established in 2002 as a public-private partnership that could provide significant financial support for global responses to HIV/AIDS, tuberculosis (TB), and malaria. This report provides background information on the Global Fund, summarizes key findings on the Global Fund's progress through 2009, outlines U.S. funding for the Fund, and analyzes issues Congress might consider as it debates the appropriate level of support to provide the Fund.
Date: August 3, 2010
Creator: Salaam-Blyther, Tiaji
Partner: UNT Libraries Government Documents Department

International HIV/AIDS, Tuberculosis, and Malaria: Key Changes to U.S. Programs and Funding

Description: This report describes U.S. efforts to combat international HIV/AIDS through the President's Emergency Plan for AIDS Relief (PEPFAR) including an overview of its implementation structure, key program elements, results, and funding from FY2004 through FY2008. It also details funding for tuberculosis, malaria, and U.S. contributions to the Global Fund during that time. This report discusses similarities and differences between H.R. 5501 and S. 2731 including proposed changes in program authorities and funding for HIV/AIDS, tuberculosis, and malaria programs.
Date: July 14, 2008
Creator: Moss, Kellie
Partner: UNT Libraries Government Documents Department

The Global Fund to Fight AIDS, Tuberculosis, and Malaria: Progress Report and Issues for Congress

Description: This report discusses the Global Fund to Fight AIDS and its progress to date, describes the funding procedure, details U.S. contributions to the organization, and presents some issues regarding the level of U.S. contributions that Congress might consider.
Date: April 14, 2008
Creator: Salaam-Blyther, Tiaji
Partner: UNT Libraries Government Documents Department

PEPFAR Reauthorization: Key Policy Debates and Changes to U.S. International HIV/AIDS, Tuberculosis, and Malaria Programs and Funding

Description: This report provides background on the President’s Emergency Plan for AIDS Relief (PEPFAR) implementation and results. It details actual and requested funding for U.S. bilateral and multilateral efforts to fight HIV/AIDS, tuberculosis, and malaria globally through FY2009. It discusses key policy debates surrounding international HIV/AIDS, malaria, and tuberculosis programs and funding as the 110th Congress considered legislation to reauthorize PEPFAR programs.
Date: January 29, 2009
Creator: Moss, Kellie
Partner: UNT Libraries Government Documents Department

The Global Fund to Fight AIDS, Tuberculosis, and Malaria: Issues for Congress and U.S. Contributions from FY2001 to FY2013

Description: The Global Fund to Fight AIDS, Tuberculosis, and Malaria (Global Fund, or the Fund) was established in 2002 as a public-private partnership that could provide significant financial support for global responses to HIV/AIDS, tuberculosis (TB), and malaria. In November 2011, the Global Fund Board announced that due to inadequate resources from donors, it would cancel its 11th round of funding, but would maintain support for existing activities to avoid disruptions in ongoing services. Global health advocates urge Congress to meet the President's FY2013 request for the Fund in order to support the sustainability of its activities and to encourage continued contributions from other donors. Although Congress has traditionally been a strong supporter of the Fund, several issues may affect congressional views about the Fund in the future, which are discussed in this report.
Date: May 15, 2012
Creator: Salaam-Blyther, Tiaji & Kendall, Alexandra E.
Partner: UNT Libraries Government Documents Department

The Global Fund to Fight AIDS, Tuberculosis, and Malaria: Issues for Congress and U.S. Contributions from FY2001 to FY2013

Description: This report examines formal interagency collaborative arrangements and activities, which are intended to enhance joint efforts and cooperation among independent federal agencies with shared responsibilities and overlapping jurisdictions. This report highlights some of the current challenges posed by HIV/AIDS, TB, and malaria, as well as several crosscutting policy issues that the 112th Congress may consider as it determines U.S. global health funding for these three diseases, including: Health Systems Strengthening, Country Ownership, Research and Development, Monitoring and Evaluation; and Bilateral vs. Multilateral Support.
Date: March 9, 2012
Creator: Salaam-Blyther, Tiaji & Kendall, Alexandra E.
Partner: UNT Libraries Government Documents Department

The Global Challenge of HIV/AIDS, Tuberculosis, and Malaria

Description: This report examines formal interagency collaborative arrangements and activities, which are intended to enhance joint efforts and cooperation among independent federal agencies with shared responsibilities and overlapping jurisdictions. This report highlights some of the current challenges posed by HIV/AIDS, TB, and malaria, as well as several crosscutting policy issues that the 112th Congress may consider as it determines U.S. global health funding for these three diseases, including: Health Systems Strengthening, Country Ownership, Research and Development, Monitoring and Evaluation; and Bilateral vs. Multilateral Support.
Date: February 23, 2012
Creator: Kendall, Alexandra E.
Partner: UNT Libraries Government Documents Department

The Global Challenge of HIV/AIDS, Tuberculosis, and Malaria

Description: This report examines formal interagency collaborative arrangements and activities, which are intended to enhance joint efforts and cooperation among independent federal agencies with shared responsibilities and overlapping jurisdictions. This report highlights some of the current challenges posed by HIV/AIDS, TB, and malaria, as well as several crosscutting policy issues that the 112th Congress may consider as it determines U.S. global health funding for these three diseases, including: Health Systems Strengthening, Country Ownership, Research and Development, Monitoring and Evaluation; and Bilateral vs. Multilateral Support.
Date: May 3, 2011
Creator: Kendall, Alexandra E.
Partner: UNT Libraries Government Documents Department

The Global Fund to Fight AIDS, Tuberculosis, and Malaria: Issues for Congress and U.S. Contributions from FY2001 to the FY2012 Request

Description: This report provides background information on the Global Fund, discusses changes the Global Fund has made to improve the efficiency of its programs and address allegations of corruption, outlines U.S. funding for the Fund, and analyzes issues Congress might consider as it debates the appropriate level of U.S support to provide the Fund.
Date: July 1, 2011
Creator: Salaam-Blyther, Tiaji
Partner: UNT Libraries Government Documents Department

The Global Fund to Fight AIDS, Tuberculosis, and Malaria: U.S. Contributions and Issues for Congress

Description: This report provides background information on the Global Fund, discusses changes the Global Fund has made to improve the efficiency of its programs and address allegations of corruption, outlines U.S. funding for the Fund, and analyzes issues Congress might consider as it debates the appropriate level of support to provide the Fund.
Date: May 3, 2011
Creator: Salaam-Blyther, Tiaji
Partner: UNT Libraries Government Documents Department

Tuberculosis: International Efforts and Issues for Congress

Description: This report discusses the infectious disease outbreaks, such as H5N1 avian influenza and severe acute respiratory syndrome (SARS), and tuberculosis (TB). The World Health Organization (WHO) estimates that someone contracts TB every second and that about one-third of all people in the world carry TB; most of these cases, however, are latent
Date: May 1, 2008
Creator: Salaam-Blyther, Tiaji
Partner: UNT Libraries Government Documents Department

U.S. Response to the Global Threat of HIV/AIDS: Basic Facts

Description: This report highlights some of the current challenges posed by HIV/AIDS, tuberculosis (TB), and malaria, as well as several crosscutting policy issues that the 112th Congress may consider as it determines U.S. global health funding for these three diseases, including: Health Systems Strengthening, Country Ownership, Research and Development, Monitoring and Evaluation; and Bilateral vs. Multilateral Support.
Date: June 15, 2012
Creator: Kendall, Alexandra E.
Partner: UNT Libraries Government Documents Department

U.S. Response to the Global Threat of HIV/AIDS: Basic Facts

Description: This report highlights some of the current challenges posed by HIV/AIDS, tuberculosis (TB), and malaria. as well as several policy issues that the 112th Congress may consider as it determines U.S. global health funding for these three diseases. Also examined are policy issues that the 112th Congress may consider, including health systems strengthening, country ownership, research and development, monitoring and evaluation, and bilateral vs. multilateral support.
Date: February 22, 2011
Creator: Kendall, Alexandra E.
Partner: UNT Libraries Government Documents Department

U.S. Response to the Global Threat of Tuberculosis: Basic Facts

Description: Tuberculosis (TB) is one of the most widespread infectious diseases in the world, infecting an average of 9 million people annually. Although TB is curable, more than 1 million TB-related deaths occur each year. Due in part to a growing global response to TB, progress has been made in combating the disease. Globally, new TB infection rates have begun to slowly decline and TB mortality rates have decreased significantly since 1990. At the same time, absolute numbers of people infected with TB, particularly in Asia and Africa, continue to rise. Congress has recognized TB as an important humanitarian issue and increasingly as a potential threat to global security. In its second session, the 112th Congress will likely debate the appropriate funding levels and optimum strategy for addressing the continued challenge of global TB.
Date: January 5, 2012
Creator: Kendal, Alexandra E.
Partner: UNT Libraries Government Documents Department

Crystallization Process of Protein Rv0731c from Mycobacterium Tuberculosis for a Successful Atomic Resolution Crystal Structure at 1.2 Angstrom

Description: Proteins are bio-macromolecules consisting of basic 20 amino acids and have distinct three-dimensional folds. They are essential parts of organisms and participate in every process within cells. Proteins are crucial for human life, and each protein within the body has a specific function, such as antibodies, contractile proteins, enzymes, hormonal proteins, structural proteins, storage proteins and transport proteins. Determining three-dimensional structure of a protein can help researchers discover the remarkable protein folding, binding site, conformation and etc, in order to understand well of protein interaction and aid for possible drug design. The research on protein structure by X-ray protein crystallography carried by Li-Wei Hung's research group in the Physical Bioscience Division at Lawrence Berkeley National Laboratory (LBNL) is focusing on protein crystallography. The research in this lab is in the process of from crystallizing the proteins to determining the three dimensional crystal structures of proteins. Most protein targets are selected from Mycobacterium Tuberculosis. TB (Tuberculosis) is a possible fatal infectious disease. By studying TB target protein can help discover antituberculer drugs, and find treatment for TB. The high-throughput mode of crystallization, crystal harvesting, crystal screening and data collection are applied to the research pipeline (Figure 1). The X-ray diffraction data by protein crystals can be processed and analyzed to result in a three dimensional representation of electron density, producing a detailed model of protein structure. Rv0731c is a conserved hypothetical protein with unknown function from Mycobacterium Tuberculosis. This paper is going to report the crystallization process and brief structure information of Rv0731c.
Date: June 8, 2009
Creator: Zhu, Liang Cong
Partner: UNT Libraries Government Documents Department

Rapid Reagentless Detection of M. tuberculosis H37Ra in Respiratory Effluents

Description: Two similar mycobacteria, Mycobacteria tuberculosis H37Ra and Mycobacteria smegmatis are rapidly detected and identified within samples containing a complex background of respiratory effluents using Single Particle Aerosol Mass Spectrometry (SPAMS). M. tuberculosis H37Ra (TBa), an avirulent strain, is used as a surrogate for virulent tuberculosis (TBv); M. smegmatis (MSm) is utilized as a near neighbor confounder for TBa. Bovine lung surfactant and human exhaled breath condensate are used as first-order surrogates for infected human lung expirations from patients with pulmonary tuberculosis. This simulated background sputum is mixed with TBa or MSm and nebulized to produce conglomerate aerosol particles, single particles that contain a bacterium embedded within a background respiratory matrix. Mass spectra of single conglomerate particles exhibit ions associated with both respiratory effluents and mycobacteria. Spectral features distinguishing TBa from MSm in pure and conglomerate particles are shown. SPAMS pattern matching alarm algorithms are able to distinguish TBa containing particles from background matrix and MSm for >50% of the test particles, which is sufficient to enable a high probability of detection and a low false alarm rate if an adequate number of such particles are present. These results indicate the potential usefulness of SPAMS for rapid, reagentless tuberculosis screening.
Date: January 29, 2008
Creator: Adams, K L; Steele, P T; Bogan, M J; Sadler, N M; Martin, S; Martin, A N et al.
Partner: UNT Libraries Government Documents Department

Tuberculosis in the Nursing Home: A Policy and Procedure Manual

Description: Tuberculosis in the nursing home is an ever-growing problem for the health care community. The incidence of tuberculosis in the United States has risen alarmingly since 1982, and high-population environments such as nursing homes are among the places where it is most prevalent. The first part of this document is an introduction to the current concerns faced by nursing home infection control personnel. It includes information about the history, symptoms, and epidemiology of the disease, as well as other topics. The second part is a policy and procedure manual that contains a basic guide to methodical testing for tuberculosis, steps for dealing with active cases of the disease, and suggestions for education of nursing home health care workers.
Access: This item is restricted to UNT Community Members. Login required if off-campus.
Date: May 2000
Creator: Mounts, Camilla M.
Partner: UNT Libraries

Development of Oral Fomulation of SCV-07 for Use in Tuberculosis

Description: An evaluation of the immunomodulatory peptide SCV-07 was conducted as a possible therapeutic treatment for tuberculosis. This evaluation included mouse models, clinical trials and various forms of the drug such as liquid injection and development of an oral pill. It was found that SCV-07 significantly increased the survival rate of animals infected with lethal doses of Mycobacterium bovis. It enhanced the functional activity of macrophages in a dose-dependent fashion. The combination of SCV-07 with bacteriostatic drugs, such as izoniazid, was particularly effective. Phase II clinical trials in a TB clinic demonstrated that the usage of the injection form of SCV-07 for lung TB treatment in combination with standard chemotherapy decreased the quantity of patients with positive sputum assays for Mycobacteria, promoted healing of cavities in lungs, stabilized parameters of cell immunity, and resulted in a significant improvement in the general condition of patients. Clinical trials results of the oral drug form are still being evaluated.
Date: November 16, 2007
Partner: UNT Libraries Government Documents Department

Analyzing Tuberculosis Vulnerabilities and Variables in Tarrant County

Description: Over 9 million new cases of tuberculosis (TB) were reported worldwide in 2013. While the TB rate is much lower in the US, its uneven distribution and associated explanatory variables require interrogation in order to determine effective strategies for intervention and control. However, paucity of case data at fine geographic scales precludes such research. This research, using zip code level data from 837 confirmed TB cases in Tarrant County obtained from Texas Department of State Health Services, explores and attempts to explain the spatial patterns of TB and related risk markers within a framework of place vulnerability. Readily available census data is then used to characterize the spatial variations in TB risk. The resulting model will enable estimations of the geographic differences in TB case variables using this readily available census data instead of time-consuming and expensive individual data collection.
Date: December 2016
Creator: McGlone, John
Partner: UNT Libraries