Search Results

Synthesis and Infrared Spectra of Substituted Phthalimidines

Description: A number of N-substituted-3-hydroxy-3-phenylphthal-imidines and some of the isomeric amides have been prepared in order to study changes in the infrared spectra of these compounds due to structural changes in the molecule, particularly with reference to a hydroxyl band at 3.0µ and a carbonyl band at 5.75µ.
Date: June 1962
Creator: Reeves, Linda R.
Partner: UNT Libraries

The Preparation of Pyridinium Derivatives by the Knoevenagel Condensation

Description: An attempt is made in the work described in this paper to extend the series started by Hall and Platas by means of a Knoevenagel condensation between 3-hydroxy-1,4-naphtho-quinone-2-(4-methylpyridinium) anhydride and various aromatic aldehydes giving rise to a series of unsaturated substituents on the four position of the pyridine ring.
Date: May 1955
Creator: Miller, Eugene James
Partner: UNT Libraries

Pyridine Derivatives of Naphthoquinone

Description: This paper deals with the preparation of pyridinium derivatives of naphthoquinone. The starting material was 2,3-dichloro-1,4-naphthoquinone, and it was reacted with pyridine and 4-n-alkyl-pyridine derivatives.
Date: August 1954
Creator: Platas, Oscar R.
Partner: UNT Libraries

Bis Ammonium Salts of Dialkylaminoalkoxypropionitriles

Description: This paper concerns the preparation of some bis derivatives of dialkylaminoalkoxypropionitirles from trimethylene, hexamethylene, octomethylene, and decamethylene bromides. These compounds are to be tested for curariform activity and anesthetic values by Parke, Davis and Company.
Date: August 1957
Creator: Woods, Roy Jack
Partner: UNT Libraries

Preparation of N-Substituted Hydroxylamines from Oxaziridines

Description: In many series of compounds, intensity of biological activity and chemical reactivity are proportional. Generally whenever a alkyl group replaces a reactive hydrogen atom, as would be the case for an N-substituted hydroxylamine as compared to hydroxylamine, the over-all biological activity of the resulting compound is lower than that of its nonalkylated analogue. Since toxicity and physiological activity are not proportional, this comparison can only suggest possible types of derivatives to prepare and test.
Date: January 1968
Creator: Truitt, Sharon G.
Partner: UNT Libraries

Synthesis of Selected 2-imidazolines

Description: Since Djerassi and Scholz found that 2-(aryloxy-methyl)imidazolines and their hydrochloride salts exhibit vasoconstrictive properties, the 1,2-(I) 1,3-(II) and 1,4-bis-(2-imidazolinylmethoxy) benzene (III) analogs (Fig. 1, p.2) were chosen for synthesis in order to test them for their effective vasoconstrictive characteristics and for whatever other physiological properties they might exhibit.
Date: June 1966
Creator: Maurer, Larry Eugene
Partner: UNT Libraries

Nitration of Thiophene Analogs of DDT

Description: Since thiophene very often yields compounds that are analogous to benzene derivatives in general physiological properties, it was decided to attempt to prepare the nitro and amino derivatives of 1,1,1-trichloro-2,2-bis-(2-thienyl)-ethane (V) as well as the nitro and amino derivatives of 2,2,3-trichloro-1,1-bis-(2-thienyl)-butane (VI).
Date: February 1953
Creator: Buttram, Jack Rhea
Partner: UNT Libraries

Conformational Analogs of Some Phytoactive Compounds

Description: In an effort to determine if there is a specific conformational structure which is most effective at the appropriate active physiological site, the synthesis of a group of sterically restricted analogs was undertaken. A portion of the polymethylene carbon skeleton of glutaric acid was replaced by selected aromatic carbons in benzenedicarboxylic acids to produce a series of ridged conformers, and the relative plant growth regulating properties of these derivatives were determined.
Date: August 1973
Creator: Skelton, Wm. Paul
Partner: UNT Libraries

Thiophene Analogs of DDT; O-Alkylhydorxylamine Hydrochorides; Dialkylaminoalkyl Esters of Phenoxyacetic Acid

Description: This thesis describes three separate and unrelated chemical experiments. The first investigates analogs for the compound DDT. The second investigates the properties of O-substituted hydroxylamines. The third investigates the action of slight changes to the structure of an antihistaminic agent.
Date: 1947
Creator: Mattison, Marjorie Bess
Partner: UNT Libraries

A-(Substitutedbenzenesulfonyl)-Substitutedacetophenones

Description: This thesis discusses the preparation of a-(o-nitro-p-methylphenylmercapto)-acetophenone by the reaction between acetophenone and o-nitro-p-methylbenzenesulfenyl chloride in boiling chloroform. The use of stannous chloride in glacial acetic acid for the reduction of nitro groups to amino groups was found generally satisfactory in spite of the difficulty often met with in isolating the amino product.
Date: 1948
Creator: Thomas, John Wylie
Partner: UNT Libraries

A Study of Sympathiomimetic Amines, Synthesis of O-Alkylhydroxylamines

Description: Although many sympathomimetic amines have been prepared, the perfect one has not yet been made. Chemists are still attempting to synthesize a selective drug with more prolonged effects and free from side reactions or compensatory vasodilation. With this idea in mind it seemed feasible to prepare a group of O-substituted hydroxylamines.
Date: 1947
Creator: Robbins, Margaret C.
Partner: UNT Libraries