67 Matching Results

Search Results

UNT 125th Anniversary Steering Committee Second Meeting

Description: Document created by UNT's 125th Anniversary Steering Committee about the prioritization of possible events, programs, and activities for the 125th Celebration. A list of attending committee representatives is included as well as a brief agenda.
Date: March 2, 2015
Creator: University of North Texas 125th Anniversary Steering Committee
Location Info:
Partner: UNT Libraries Special Collections

Can You Hear Me Now? Benefits of Frequency-Modulated (FM) Systems for Adults and Children Using Cochlear Implants: A Meta-Analysis Approach [Presentation]

Description: Presentation for the 2007 University Scholars Day at the University of North Texas discussing research on the benefits of frequency-modulated (FM) systems for adults and children using cochlear implants.
Date: March 29, 2007
Creator: Kleineck, Mary Pat & Schafer, Erin
Partner: UNT Honors College

Analysis of Auditory Measures in Normal Hearing Young Male Adult Cigarette Smokers Using Multiple Variable Selection Methods with Predictive Validation Assessments

Description: Article on an analysis of auditory measures in normal hearing young male adult cigarette smokers using multiple variable selection methods with predictive validation assessments.
Date: October 25, 2009
Creator: Gopal, Kamakshi V.; Herrington, Richard & Pearce, Jacquelin
Partner: UNT College of Arts and Sciences

In Vitro Cortical Networks for Disease Modeling and Drug Evaluation

Description: In translational research, disease models in preclinical studies are used as media for discovery of drugs or novel therapeutics. Development of in vitro models for various neurological diseases that enable efficient pharmacological or toxicological screening has been ongoing but challenging. Recognizing the potential benefit of in vitro disease models, dysfunctions in the cortical neuronal networks were induced to mimic the functional pathology of neurological symptoms using microelectrode arrays. Two different disease states – tinnitusand excitotoxicity – were investigated and discussed. In this model, pentylenetetrazol-induced increase in spontaneous firing rate and synchrony in the auditory cortical networks was used as correlate of tinnitus. Potential tinnitus treatment drugs from several different classes – including the novel class of potassium channel openers – were screened and quantified. The potentialtherapeutic values of these drugs were also discussed as the basis for drug repurposing. Functional excitotoxicity was induced by cisplatin (a cancer drug that causes neurological sideeffects) and glutamate (the major excitatory neurotransmitter). As proof-of-principle that the model may contribute to expediting the development of therapeutics, cisplatin excitotoxicity wasprevented by the antioxidant D-methionine, while glutamate excitotoxicity was prevented by ceftriaxone (a modulator of a glutamate reuptake transporter). In the latter part of the study, with results linking two of the screened drugs L-carnitine and D-methionine to GABAA receptor activation, it was demonstrated that this model not only served as an efficient drug-screening platform, but can be utilized to functionally investigate the underlying mechanism of drugs. Inaddition, several practical or conceptual directions for future studies to improve on this in vitro disease model are suggested.
Date: December 2013
Creator: Wu, Calvin
Partner: UNT Libraries

Dynamic Measurement of Intraoral Pressure and Sound Pressure With Laryngoscopic Characterization During Oboe Performance

Description: Measurements of intraoral pressure (IOP) and sound pressure level (SPL) were taken of four oboists as they performed two sets of musical exercises: (1) crescendo-decrescendo from pp to ff and back to pp on the pitches D4, G4, C5 and A5, and (2) straight and vibrato performances of the same four pitches at mf. Video images of the vocal tract were also made using flexible fiberoptic nasoendoscopy (FFN). IOP and SPL data were captured in real time by the WinDaq®/Lite software package, with the dB meter located 8-9 inches in directly front of the oboe bell. The study yielded minimum and maximum values from 21.04 to 57.81 mm Hg and from 65.53 to 100.89 dB across all pitches examined. Discussion is included for the following topics: (1) the oboe’s sound envelope, or functional range of IOP and SPL values at different pitch levels, including the nonlinearity in the relationship between IOP and SPL on the oboe, (2) the static activation and kinetic maintenance thresholds for reed vibration, (3) the effect of vibrato on IOP/SPL, (4) the utilization of the vocal tract during execution of dynamic changes and vibrato, and (5) the impact of player experience on control of physical variables.
Date: December 2011
Creator: Adduci, Michael Douglas
Partner: UNT Libraries

The Effects of Selective Serotonin Reuptake Inhibitors (Ssri) on Auditory Measures in Clinically Depressed Subjects.

Description: The purpose of this study was to investigate the relationship between selective serotonin reuptake inhibitor (SSRI) medication on auditory skills in clinically depressed subjects. Experimental subjects prescribed an SSRI were tested in a medicated and an unmedicated condition, and the test results were compared. Furthermore, the experimental group was compared with a control group consisting of normal subjects. Test measures included pure tone audiometry, tympanometry, acoustic reflex thresholds, and auditory electrophysiologic measures such as auditory brainstem and auditory late responses. An assessment scale for depression (Beck Depression Inventory-II) was also used. Results indicated statistically significant differences for the BDI-II between the control and experimental groups for both conditions. Electrophysiologic measures indicated a significantly shorter latency for auditory late potential P1 at 55 dBnSL, and a significantly larger amplitude at 45 dBnSL for the N1/P2 component for the unmedicated group. Although the other measures showed trends, they did not reach significance.
Date: May 2002
Creator: Goodale, Elizabeth S.
Partner: UNT Libraries

The Effects of Selective Serotonin Reuptake Inhibitors (SSRI) on Auditory Measures in Women

Description: This study examined the relationship between selective serotonin reuptake inhibitor (SSRI) medication and auditory measures in clinically depressed women. Experimental subjects were tested in both a medicated and unmedicated condition. Experimental subjects were compared to a normal control group; additionally intrasubject comparison was made within the experimental group. Test measures included: audiometry, tympanometry, otoacoustic emissions, uncomfortable loudness level, masking level difference, SCAN-A, Synthetic Sentence Identification (SSI), and the low predictability section of the Revised Speech in noise (RSPIN). The unmedicated group scored significantly less favorably than the control group on the following tests; SCAN-A (composite, filtered words, and auditory figure ground), R-SPIN (0MCR condition in both the right and left ears). Additionally, the unmedicated group scored significantly less favorably than the medicated group on the SSI (-20MCR condition right ear only) and of the R-SPIN (0MCR condition right ear only). Other test measures indicated consistent trends but did reach significance.
Date: May 2002
Creator: Briley, Kelly Anne
Partner: UNT Libraries

A preliminary study on the effect of selective serotonin reuptake inhibitors on peripheral and lower brainstem auditory processing.

Description: This study compared auditory behavioral and physiologic measures in normal control subjects and subjects prescribed with a selective serotonin reuptake inhibitor (SSRI) who were yet to take the drug and those currently taking an SSRI. Test measures used were pure tone averages (PTA), acoustic reflex thresholds, uncomfortable loudness levels (UCL), otoacoustic emissions, masking level difference, temporal integration, amplitude resolution, and Beck Depression Inventory-II (BDI-II) scores. Results indicated that there was a significant difference in the amplitude resolution of the unmedicated group when compared to the medicated and the control group. There was also a significant positive correlation between dynamic range (difference between UCL and PTA) and amplitude resolution. The BDI-II revealed a significant difference between the scores of the unmedicated and the control group as well as the medicated and the control group. Although other test measures indicated differences between the groups, the differences were not statistically significant.
Access: This item is restricted to UNT Community Members. Login required if off-campus.
Date: May 2001
Creator: Carney, Lara E.
Partner: UNT Libraries