Influence of a Human Lipodystrophy Gene Homologue on Neutral Lipid Accumulation in Arabidopsis Leaves
Description:
CGI-58 is the defective gene in the human neutral lipid storage disease called Chanarin-Dorfman syndrome. This disorder causes intracellular lipid droplets to accumulate in nonadipose tissues, such as skin and blood cells. Here, disruption of the homologous CGI-58 gene in Arabidopsis thaliana resulted in the accumulation of neutral lipid droplets in mature leaves. Mass spectroscopy of isolated lipid droplets from cgi-58 loss-of-function mutants showed they contain triacylglycerols with common l…
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Date:
August 2016
Creator:
James, Christopher Neal
Partner:
UNT Libraries