726 Matching Results

Search Results

Biomedical engineering support. Annual report

Description: The purpose of this research was to provide the artificial heart design information necessary for the proper development of an implantable nuclear power supply for the artificial heart. A Kwan-Gett hemispherical artificial heant made of silicone rubber was attached to a mock circulation instrumented with pressure, volume and fiow transducers and measurements made of power input to the artificial heant at various locations, source of power losses and efficiencies of the artificial heart under a variety of pumping conditions, volumetric efficiency, pressure required to move the diaphragm of the artificial heat, required motion of the heant diaphragm and pumping characteristics of the antificial heant. The in vitro measurements have been verified by in vivo experiments in calves. The preliminary design of a pumping chamber for the nuclear powered heart has been completed. (auth)
Date: July 15, 1972
Creator: Kolff, W.J.
Partner: UNT Libraries Government Documents Department

Biomedical engineering research at DOE national labs

Description: Biomedical Engineering is the application of principles of physics, chemistry, nd engineering to problems of human health. The National Laboratories of the U.S. Department of Energy have been leaders in this scientific field since 1947. This inventory of their biomedical engineering projects was compiled in January 1999.
Date: March 1, 1999
Partner: UNT Libraries Government Documents Department

Biomedical engineering support. Quarterly progress report

Description: During the quarter covered by this progress report (December 15, 1971 to March 15, 1972), the effects of variations in arterial pressure and heart rate on cardiac ouiput, efficiency as measured at the heart diaphragm, maximum air chamber pressure, average input power to the heart diaphragm, maximum blood chamber pressure and volumetric efficiency have been determined at various atrial pressures for a 7 cm base Kwan-Gett artificial heart made of smooth Silastic and equipped with Silastic flap inflow and Silastic tricuspid outflow valves. One animal experiment has been completed in which the in vitro measurements made on the artificial heart were verified in vivo. A second animal experiment in which the output power of the artificial heart will be determined over a long period of time is now in progress. Preliminary consideration has been given to the establishment of a nuclear powered artificial heart system in vitro test program. A preliminary design of an artificial heart to be driven by a nuclear engine has been drawn. (auth)
Date: March 15, 1972
Creator: Kolff, W.J.
Partner: UNT Libraries Government Documents Department

Biomedical engineering support. Quarterly progress report

Description: During the quarter covered by this progress report (July 15October 15, 1972), the power requirements of a bench test heart pump were determined. Cardiac output response, peak pusher cup forces, and power efficiencies were also determined. These measurements were made in vitro. Several geometries of connectors for the heart pump were evaluated for fit in dead calves to determine a practical configuration. Two models of the nuclear engine were implanted in calves to evaluate the chronic effects of engine weight and size. (auth)
Date: October 15, 1972
Creator: Kolff, W.J.; Backman, D.K. & Sandquist, G.M.
Partner: UNT Libraries Government Documents Department

Biomedical engineering support. Quarterly progress report, June 15, 1971-- September 15, 1971

Description: A daily power profile for the artificial heart has been determined from the literature and equipment and instrumentation has been assembled for measuring the efficienciea and power losses in the Kwan-Geff antificial heart. (auth)
Date: October 11, 1971
Creator: Kolff, W.J. & Donovan, F.M. Jr.
Partner: UNT Libraries Government Documents Department

Biomedical engineering support. Quarterly progress report, September 15, 1971--December 15, 1971

Description: The power input to the air drive line, input to the air chamber, input to the pumping diaphragm and output from the Kwan-Gett artificial heart has been measured at different atrial pressures with a constant frequency of 120 beats per minute and constant mean arterial pressure of 100 mm Hg. These measurements were made in vitro. The various efficiencies, cardiac outputs and pressures corresponding to the power measurements were also determined. (auth)
Date: December 16, 1971
Creator: Kolff, W.J. & Donovan, F.M. Jr.
Partner: UNT Libraries Government Documents Department

Biomedical engineering support. Final report, June 15, 1971--June 30, 1979

Description: On June 15, 1971 the Institute for Biomedical Engineering at the University of Utah contracted with the USAEC to provide biomedical support for an Artificial Heart Program. The goal of the program was to conceive, design, construct and test a prototype artificial heart system powered by an implantable radioisotope heat source. The system would serve as a total artificial heart for animal experiments and for studies directed at developing a total heart replacement system for humans. The major responsibilities of the Institute during the eight year contract period were to design, construct and test all blood handling components of the system and prove in vivo accommodation, performance and adequacy of the system in experimental animals. Upon completion of development of the Implantable Version of the Bench Model Blood Pump, a long series of comprehensive in vitro and in vivo experiments were conducted. In vivo experiments with the system conducted in calves demonstrated the general accommodation, adequate performance and good capacity to sustain the calf as a heart model for up to 36 days. During the more successful in vivo experiments the implanted calves were able to eat, drink, stand, exercise on a treadmill, and exhibited normal blood chemistry and pulmonary function.
Date: January 1, 1979
Creator: Kolff, W.J.; Sandquist, G.; Olsen, D.B. & Smith, L.M.
Partner: UNT Libraries Government Documents Department

Biomedical engineering support. Quarterly progress report, October 15, 1972--February 15, 1973

Description: During the quarter covered (October 15, 1972 to February 15, 1973), additional models of the nuclear engine were implanted in calves to evaluate the chronic effects of weight and size. Further characterization of the bench test heart pump was performed, The effect of pump rate on cardiac output was evaluated. The effect of outflow (anterial) pressure on cardiac output was evaluated. Bjork- Shiley valves with stainless steel disks and pyrolitic carbon disks were tested and the effect of cardiac output evaluated. A design of a quick connect system to enable rapid connection of the atrial cuffs and anterial graphs to the blood pump was undertaken. Molds of the implantable version of the ventricles were completed, and construction techniques and evaluation of the ventricles is now in progress. A protocol for the implantation of the pump mechanism into calves for testing is under consideration. (auth)
Date: February 15, 1973
Creator: Kolff, W.J.
Partner: UNT Libraries Government Documents Department

First operation of the medical research facility at the NSLS for coronary angiography

Description: The Synchrotron Medical Research Facility (SMERF) at the National Synchrotron Light Source has been completed and is operational for human coronary angiography experiments. The imaging system and hardware have been brought to SMERF from the Stanford Synchrotron Radiation Laboratory where prior studies were carried out. SMERF consists of a suite of rooms at the end of the high field superconducting wiggler X17 beamline and is classified as an Ambulatory health Care Facility. Since October of 1990 the coronary arteries of five patients have been imaged. Continuously improving image quality has shown that a large part of both the right coronary artery and the left anterior descending coronary artery can be imaged following a venous injection of contrast agent. 16 refs., 4 figs.
Date: January 1, 1991
Creator: Thomlinson, W.; Gmuer, N.; Chapman, D.; Garrett, R.; Lazarz, N.; Moulin, H. (Brookhaven National Lab., Upton, NY (United States)) et al.
Partner: UNT Libraries Government Documents Department

Development of the augmented musculature device.

Description: We developed an Augmented Musculature Device (AMD) that assists the movements of its wearer. It has direct application to aiding military and law enforcement personnel, the neurologically impaired, or those requiring any type of cybernetic assistance. The AMD consists of a collection of artificial muscles, each individually actuated, strategically placed along the surface of the human body. The actuators employed by the AMD are known as 'air muscles' and operate pneumatically. They are commercially available from several vendors and are relatively inexpensive. They have a remarkably high force-to-weight ratio--as high as 400:1 (as compared with 16:1 typical of DC motors). They are flexible and elastic, even when powered, making them ideal for interaction with humans.
Date: December 1, 2004
Creator: Rohrer, Brandon Robinson & Pankretz, Ty
Partner: UNT Libraries Government Documents Department

A survey of Asian life scientists :the state of biosciences, laboratory biosecurity, and biosafety in Asia.

Description: Over 300 Asian life scientists were surveyed to provide insight into work with infectious agents. This report provides the reader with a more complete understanding of the current practices employed to study infectious agents by laboratories located in Asian countries--segmented by level of biotechnology sophistication. The respondents have a variety of research objectives and study over 60 different pathogens and toxins. Many of the respondents indicated that their work was hampered by lack of adequate resources and the difficulty of accessing critical resources. The survey results also demonstrate that there appears to be better awareness of laboratory biosafety issues compared to laboratory biosecurity. Perhaps not surprisingly, many of these researchers work with pathogens and toxins under less stringent laboratory biosafety and biosecurity conditions than would be typical for laboratories in the West.
Date: February 1, 2006
Creator: Gaudioso, Jennifer Marie
Partner: UNT Libraries Government Documents Department

Quantum squeezed light for probing mitochondrial membranes and study of neuroprotectants.

Description: We report a new nanolaser technique for measuring characteristics of human mitochondria. Because mitochondria are so small, it has been difficult to study large populations using standard light microscope or flow cytometry techniques. We recently discovered a nano-optical transduction method for high-speed analysis of submicron organelles that is well suited to mitochondrial studies. This ultrasensitive detection technique uses nano-squeezing of light into photon modes imposed by the ultrasmall organelle dimensions in a semiconductor biocavity laser. In this paper, we use the method to study the lasing spectra of normal and diseased mitochondria. We find that the diseased mitochondria exhibit larger physical diameter and standard deviation. This morphological differences are also revealed in the lasing spectra. The diseased specimens have a larger spectral linewidth than the normal, and have more variability in their statistical distributions.
Date: January 1, 2005
Creator: Gourley, Paul Lee; Copeland, Robert Guild; McDonald, Anthony Eugene; Hendricks, Judy K. & Naviaux, Robert K. (University of California, San Diego, CA)
Partner: UNT Libraries Government Documents Department

Distinguishing morphological changes with polarized light scattering

Description: Results of work determining how different biological structures contribute to light scattering will be presented. Further, measurements of phantoms that mimic structural changes expected in vivo will be presented. It is found that polarized measurements can discriminate between phantoms with similar properties.
Date: January 1, 2002
Creator: Johnson, T. M. (Tamara M.); Aida, T. (Toru); Carpenter, S. (Susan); Freyer, J. P. (James P.) & Mourant, J. R. (Judith R.)
Partner: UNT Libraries Government Documents Department