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Description: Pair of gloves of ivory colored leather. On back of each glove is a stitched swirl design of 5 ribs. The gloves widen to end with piped hems, and extend to about mid-forearm. Appears to be a youth size. Stamped inside gloves: A) "ARIS" logo in hemisphere; "U.S. Pat. / Aug. 22'22"; and with various stamped numbers inside the glove for sewing and matching pieces. B) "5 3/4"; "U.S. Pat. / Sept 19'22 / Made in Germany"; and with various stamped numbers inside the glove for sewing and matching pieces.
Date: 1922
Creator: Aris
Partner: UNT College of Visual Arts + Design


Description: Gloves of light off white kid leather with brown piping. Hands have 3 darts outlined with brown thread on top; wrist portion extends almost to elbow; triangular inserts of same leather with tiny circles punched out lays over brown leather create full trumpet shaped wrist opening; vent at bottom wrist near hand with 2 pearl button closures. Stamped inside of left glove: "Made in Saxony"; "9468"; "V T ES / 1445"; "ARIS" (logo within arch); "US PAT / AUG 22 '27" Stamped inside of right glove: "6"; "US PAT / SEPT 19'22"' "3126 / 8"; "9468"
Date: 1927/1939
Creator: Aris Glove Company
Partner: UNT College of Visual Arts + Design

Heterozygosity for a Bub1 mutation causes female-specific germ cell aneuploidy in mice

Description: Aneuploidy, the most common chromosomal abnormality at birth and the main ascertained cause of pregnancy loss in humans, originates primarily from chromosome segregation errors during oogenesis. Here we report that heterozygosity for a mutation in the mitotic checkpoint kinase gene, Bub1, induces aneuploidy in female germ cells of mice, and that the effect increases with advancing maternal age. Analysis of Bub1 heterozygous oocytes showed that aneuploidy occurred primarily during the first meiotic division and involved premature sister chromatid separation. Furthermore, aneuploidy was inherited in zygotes and resulted in the loss of embryos after implantation. The incidence of aneuploidy in zygotes was sufficient to explain the reduced litter size in matings with Bub1 heterozygous females. No effects were seen in germ cells from heterozygous males. These findings show that Bub1 dysfunction is linked to inherited aneuploidy in female germ cells and may contribute to the maternal age-related increase in aneuploidy and pregnancy loss.
Date: June 24, 2009
Creator: Leland, Shawn; Nagarajan, Prabakaran; Polyzos, Aris; Thomas, Sharon; Samaan, George; Donnell, Robert et al.
Partner: UNT Libraries Government Documents Department


Description: Cigarette smoking in men has been associated with increased chromosomal abnormalities in sperm and with increased risks for spontaneous abortions, birth defects and neonatal death. Little is known, however, about the reproductive consequences of paternal exposure to second-hand smoke. We used a mouse model to investigate the effects of paternal exposure to sidestream (SS) smoke, the main constituent of second-hand smoke, on the genetic integrity and function of sperm, and to determine whether male germ cells were equally sensitive to mainstream (MS) and SS smoke. A series of sperm DNA quality and reproductive endpoints were investigated after exposing male mice for two weeks to MS or SS smoke. Our results indicated that: (i) only SS smoke significantly affected sperm motility; (ii) only MS smoke induced DNA strand breaks in sperm; (iii) both MS and SS smoke increased sperm chromatin structure abnormalities; and (iv) MS smoke affected both fertilization and the rate of early embryonic development, while SS smoke affected fertilization only. These results show that MS and SS smoke have differential effects on the genetic integrity and function of sperm and provide further evidence that male exposure to second-hand smoke, as well as direct cigarette smoke, may diminish a couple's chance for a successful pregnancy and the birth of a healthy baby.
Date: March 13, 2009
Creator: Polyzos, Aris; Schmid, Thomas Ernst; Pina-Guzman, Belem; Quintanilla-Vega, Betzabet & Marchetti, Francesco
Partner: UNT Libraries Government Documents Department

Phenotypic transition maps of 3D breast acini obtained by imaging-guided agent-based modeling

Description: We introduce an agent-based model of epithelial cell morphogenesis to explore the complex interplay between apoptosis, proliferation, and polarization. By varying the activity levels of these mechanisms we derived phenotypic transition maps of normal and aberrant morphogenesis. These maps identify homeostatic ranges and morphologic stability conditions. The agent-based model was parameterized and validated using novel high-content image analysis of mammary acini morphogenesis in vitro with focus on time-dependent cell densities, proliferation and death rates, as well as acini morphologies. Model simulations reveal apoptosis being necessary and sufficient for initiating lumen formation, but cell polarization being the pivotal mechanism for maintaining physiological epithelium morphology and acini sphericity. Furthermore, simulations highlight that acinus growth arrest in normal acini can be achieved by controlling the fraction of proliferating cells. Interestingly, our simulations reveal a synergism between polarization and apoptosis in enhancing growth arrest. After validating the model with experimental data from a normal human breast line (MCF10A), the system was challenged to predict the growth of MCF10A where AKT-1 was overexpressed, leading to reduced apoptosis. As previously reported, this led to non growth-arrested acini, with very large sizes and partially filled lumen. However, surprisingly, image analysis revealed a much lower nuclear density than observed for normal acini. The growth kinetics indicates that these acini grew faster than the cells comprising it. The in silico model could not replicate this behavior, contradicting the classic paradigm that ductal carcinoma in situ is only the result of high proliferation and low apoptosis. Our simulations suggest that overexpression of AKT-1 must also perturb cell-cell and cell-ECM communication, reminding us that extracellular context can dictate cellular behavior.
Date: February 18, 2011
Creator: Tang, Jonathan; Enderling, Heiko; Becker-Weimann, Sabine; Pham, Christopher; Polyzos, Aris; Chen, Chen-Yi et al.
Partner: UNT Libraries Government Documents Department