Search Results

In the Details

Description: Work of art of oil on panel by artist Hannah Aaron as part of a 2020 MFA Exhibition, entitled "A Narrative Rewritten"
Date: 2020
Creator: Aaron, Hannah
Partner: UNT College of Visual Arts + Design

Left Hook

Description: Work of art of oil on canvas by artist Hannah Aaron as part of a 2020 MFA Exhibition, entitled "A Narrative Rewritten"
Date: 2020
Creator: Aaron, Hannah
Partner: UNT College of Visual Arts + Design
open access

A Narrative Rewritten

Description: In A Narrative Rewritten, I explore two distinct periods of my past. One group of work deals with the emotional effects of trauma I experienced as a child during years of practicing ballet. The other celebrates a pivotal moment of spiritual awakening that gave me the strength to confront internal falsehoods I previously developed. I paint from observation, to engage with my subject and to ground myself in the present moment. In my oil paintings, I paint representationally, while delving in to the spectrum of abstraction. I use imagery symbolically from ballet and boxing to represent a shift from inadequacy to empowerment.
Date: May 2020
Creator: Aaron, Hannah
Partner: UNT College of Visual Arts + Design

Nitpick

Description: Work of art of oil on canvas by artist Hannah Aaron as part of a 2020 MFA Exhibition, entitled "A Narrative Rewritten"
Date: 2020
Creator: Aaron, Hannah
Partner: UNT College of Visual Arts + Design

Perfect Bun

Description: Work of art of oil on canvas by artist Hannah Aaron as part of a 2020 MFA Exhibition, entitled "A Narrative Rewritten"
Date: 2020
Creator: Aaron, Hannah
Partner: UNT College of Visual Arts + Design

Psalm 144:1

Description: Work of art of oil on canvas by artist Hannah Aaron as part of a 2020 MFA Exhibition, entitled "A Narrative Rewritten"
Date: 2020
Creator: Aaron, Hannah
Partner: UNT College of Visual Arts + Design

Soft Hand

Description: Work of art of oil on canvas by artist Hannah Aaron as part of a 2020 MFA Exhibition, entitled "A Narrative Rewritten"
Date: 2020
Creator: Aaron, Hannah
Partner: UNT College of Visual Arts + Design

Health Reform Implementation Analysis: A Guide to Policy Development for Geriatric Care Planning, Integration and Evaluation

Description: In the context of health care delivery for senior citizens, this research utilizes three studies that examine the development and implementation of health policy and the factors that can directly or indirectly impact the effective delivery of health services to senior citizens. It utilizes three essays employing mixed methods (qualitative and quantitative) methods including semi structured interviews, multiple regression and partial least squares structural equation modelling to examine the extent to which the implementation of health services delivered attributes of primary and integrated care to seniors. The two essays identified methods, approaches and strategies of integrated care relevant to the development of policy that can be successfully implemented when the contextual issues that older people consider to be important in maintaining their functional capabilities and their motivation to improve health as perceived by them are addressed. Consequent upon the results from these studies, the third essay examines the methodological issues on integrated geriatric care implementation when guidelines for effective policy development identified were not followed. By highlighting the relationship between effective policy and patient satisfaction, these three essays' recommended approach enhances the theory of health design that confirms that theoretical models of primary care must incorporate the system, process and service delivery levels of care to optimize seniors health.
Date: August 2020
Creator: Abah, Theresa
Partner: UNT Libraries
open access

Stimulus Control Effects of Changes in Schedules of Reinforcement

Description: Sometimes, changes in consequences are accompanied by a clear stimulus change explicitly arranged by the experimenter. Other times when new consequences are in effect, there is little or no accompanying stimulus change explicitly arranged by the experimenter. These differences can be seen in the laboratory as multiple (signaled) schedules and mixed (unsignaled) schedules. The current study used college students and a single-subject design to examine the effects of introducing signaled and unsignaled schedules, and the transitions between them. In one phase, a card was flipped from purple to white every time the schedule was switched from VR-3 to FT-10. In another phase, the schedule still changed periodically, but the card always remained on the purple side. Results showed that the participants' responding was controlled by the schedule of reinforcement, by the color of the card, or both. These results suggest that changes in patterns of reinforcement lead to changes in stimulus control. In addition, the stimulus control for a behavior can come from several different sources. During teaching, it may facilitate the development of stimulus control to change the environment when a new behavior is required.
Date: August 2020
Creator: Abdel-Jalil, Awab
Partner: UNT Libraries

Impact of Anti-S2 Peptides on a Variety of Muscle Myosin S2 Isoforms and Hypertrophic Cardiomyopathy Mutants Revealed by Fluorescence Resonance Energy Transfer and Gravitational Force Spectroscopy

Description: Myosin subfragment-2 (S2) is an intrinsically unstable coiled coil. This dissertation tests if the mechanical stability of myosin S2 would influence the availability of myosin S1 heads to actin thin filaments. The elevated instability in myosin S2 coiled coil could be one of the causes for hypercontractility in Familial Hypertrophic Cardiomyopathy (FHC). As hypothesized FHC mutations, namely E924K and E930del, in myosin S2 displayed an unstable myosin S2 coiled coil compared to wild type as measured by Fluorescence Resonant Energy Transfer (FRET) and gravitational force spectroscopy (GFS). To remedy this, anti-S2 peptides; the stabilizer and the destabilizer peptides by namesake were designed in our lab to increase and decrease the stability of myosin S2 coiled coil to influence the actomyosin interaction. Firstly, the effectiveness of anti-S2 peptides were tested on muscle myosin S2 peptides across MYH11 (smooth), MYH7 (cardiac), and MYH2 (skeletal) with GFS and FRET. The results demonstrated that the mechanical stability was increased by the stabilizer and decreased by the destabilizer across the cardiac and skeletal myosin S2 isoform but not for the smooth muscle isoform. The destabilizer peptide had dissociation binding constants of 9.97 × 10-1 μM to MYH7 isoform, 1.00 μM to MYH2 isoform, and no impact on MYH11, and the stabilizer peptide had dissociation binding constants of 2.12 × 10-2 μM to MYH7 isoform, 3.41 × 10-1 μM to MYH2 isoform, and no impact on MYH11 revealed by FRET. In presence of the stabilizer, FRET assay, affinity of the E930del and E924K increased by 10.23 and 0.60 fold respectively. The force required to uncoil muscle myosin S2 peptides in the presence of the stabilizer peptide was more than in its absence in muscle myosin S2 isoforms of MYH7 (1.80 fold higher), MYH2 (1.40 fold higher), and E930del (2.60 fold higher) and no change for MYH11 …
Date: August 2020
Creator: Aboonasrshiraz, Negar
Partner: UNT Libraries

Adolescent Self-Theories of Singing Ability within the Choral Hierarchy

Description: The purpose of this study was to explore adolescent self-views of singing ability through both implicit theories and self-concept meaning systems. A secondary purpose of this study was to examine these self-views specifically in the context of a choral hierarchy. Using a researcher-designed survey instrument, I gathered data from middle- and high-school students currently enrolled in a choir program organized in a hierarchical structure. I analyzed descriptive statistics of survey responses to items designed to measure implicit theories of singing ability, singing self-concept, and goal orientation. I also examined differences among participants by ensemble placement in implicit theory and self-concept scores, correlation between implicit theory and self-concept, and whether implicit theory, self-concept, goal orientation, or current enrollment could predict future enrollment decisions. In addition to these quantitative measures, I coded open-ended responses to two failure scenarios and examined participant responses by ensemble and gender. Both implicit theory and self-concept scores were higher for participants at the top of the choral hierarchy than at the bottom. Open-ended responses, however, did not align with the implicit theory scale and a number of students presented a false growth mindset. Open-ended responses also indicated that failure scenarios were likely to result in an altered view of the self and shame in placement in an ensemble at the bottom of the choral hierarchy. The means scores for participants in the middle- and high-school ensembles in both implicit theory and self-concept were significantly different, with participants in the high-school ensembles having higher scores in both constructs. Implicit theory and self-concept were significantly related, and self-concept, goal orientation, and current enrollment significantly predicted future enrollment decisions.
Date: May 2020
Creator: Adams, Kari
Partner: UNT Libraries

Exploring the Impact of Decentralization of Decision Making and Complexity on Supply Chain Resilience

Description: The purpose of this three-essay dissertation is to synthesize and extend the effects of decentralization in decision-making and supply chain complexity in the context of supply chain resilience (SCRES).First essay contributes to theory and practice by expanding resilience thinking into including supply chain orientation and organizational structure and their implications and also responds to prior research arguing for the importance of identifying organizational factors that improve supply chain resilience. Second essay contributes to the supply chain organizational structure and SCRES literature by not just providing empirical support for decentralization of decision making in times of disruptions but more precisely by showing the factors that either impede or facilitate decentralization at the organizational level. Understanding the interplay among these factors is critical to explaining the lack of success for decentralization in the context of SCRES. Third essay contributes to practice by reviewing some of the major complexity drivers present in the supply chains and providing strategies along with a four-step process that practitioners can use to manage complexity.
Date: August 2020
Creator: Adana, Saban
Partner: UNT Libraries

Multifactorial Determinants of Change in Mental Disorder and Happiness among Older Americans

Description: Mental health is an intrinsic capability that constitute an essential component of healthy aging. Mental health is constituted by positive constructs such as happiness and negative constructs (mental disorders) such as depression. As people grow older, they become more prone to developing mental disorders which are linked to poorer quality of life, increased disability, increased utilization and cost of health services, and higher rates of suicide. This dissertation involved three studies that focused on factors that predict change in mental disorders and happiness of older Americans over a period of five years. Two waves of publicly available national representative data from the National Social Life Health and Aging Project (NSHAP) collected in 2010 and 2015 were used. A total of 2210 older adults within the ages 62-90 years were used in the analyses. Mental health measures were CES-Depression scale, HADS anxiety scale, and self-rated happiness. Essay 1 aimed to identify the important aspects of older adults' interaction with their neighborhood that predict the presence of mental disorder and happiness. Essay 2 evaluated the psychosocial factors that predict change in mental disorder and happiness of older adults, whereas essay 3 investigated the multifactorial determinants of change in mental disorder and happiness of older adults. These three essays provide insight into the impact of mental health in old age and the role of environmental, social, and demographic factors in successful aging. It also provides gaps for future research in the field of mental health and aging.
Date: August 2020
Creator: Adaralegbe, Adeleye Ayinde
Partner: UNT Libraries
open access

The Role of Eigenvalues of Parity Check Matrix in Low-Density Parity Check Codes

Description: The new developments in coding theory research have revolutionized the application of coding to practical systems. Low-Density Parity Check (LDPC) codes form a class of Shannon limit approaching codes opted for digital communication systems that require high reliability. This thesis investigates the underlying relationship between the spectral properties of the parity check matrix and LDPC decoding convergence. The bit error rate of an LDPC code is plotted for the parity check matrix that has different Second Smallest Eigenvalue Modulus (SSEM) of its corresponding Laplacian matrix. It is found that for a given (n,k) LDPC code, large SSEM has better error floor performance than low SSEM. The value of SSEM decreases as the sparseness in a parity-check matrix is increased. It was also found from the simulation that long LDPC codes have better error floor performance than short codes. This thesis outlines an approach to analyze LDPC decoding based on the eigenvalue analysis of the corresponding parity check matrix.
Date: August 2020
Creator: Adhikari, Dikshya
Partner: UNT Libraries

Identification, Characterization and Engineering of UDP-Glucuronosyltransferases for Synthesis of Flavonoid Glucuronides

Description: Flavonoids are polyphenolics compounds that constitute a major group of plant specialized metabolites, biosynthesized via the phenylpropanoid/polymalonate pathways. The resulting specialized metabolites can be due to decoration of flavonoid compounds with sugars, usually glucose, by the action of regiospecific UDP-glycosyltransferase (UGT) enzymes. In some cases, glycosylation can involve enzymatic attachment of other sugar moieties, such as glucuronic acid, galactose, rhamnose or arabinose. These modifications facilitate or impact the bioactivity, stability, solubility, bioavailability and taste of the resulting flavonoid metabolites. The present work shows the limitations of utilizing mammalian UDP-glucuronosyltransferases (UGATs) for flavonoid glucuronidation, and then proceeds to investigate plant UG(A)T candidates from the model legume Medicago truncatula for glucuronidating brain-targeted flavonoid metabolites that have shown potential in neurological protection. We identified and characterized several UG(A)T candidates from M. truncatula which efficiently glycosylate various flavonoids compounds with different/multiple regiospecificities. Biochemical characterization identified one enzyme, UGT84F9, that efficiently glucuronidates a range of flavonoid compounds in vitro. In addition, examination of the ugt84f9 gene knock-out mutation in M. truncatula indicates that UGT84F9 is the major UG(A)T enzyme that is necessary and sufficient for attaching glucuronic acid to flavonoid aglycones, particularly flavones, in this species. Finally, the identified UG(A)T candidates were analyzed via homology modeling and site-directed mutagenesis towards increasing the repertoire of UG(A)Ts applicable for synthesis of flavonoid glucuronides with potential human health benefits in neurological protection.
Date: December 2020
Creator: Adiji, Olubu Adeoye
Partner: UNT Libraries

Traffic-Generated Air Pollution-Exposure Mediated Expression of Factors Associated with Progression of Multiple Sclerosis in a Female Polipoprotein E Knockout Mouse Model

Description: Environmental air pollution is one risk factor associated with the onset and progression of multiple sclerosis (MS). In this project, we investigated the effects of ubiquitous traffic-generated pollutants, namely a mixture of gasoline and diesel vehicle exhaust (MVE), on signaling pathways associated with the pathophysiology of MS in the central nervous system (CNS) of either ovary intact (ov+) or ovariectomized (ov-) female Apolipoprotein (Apo) E-/-. Specifically, we investigated whether a subchronic inhalation exposure to MVE (200 PM μg/m3; 6 hr/d, 7d/wk, 30d) vs. filtered air (FA) controls altered myelination, T cell infiltration, blood-brain barrier (BBB) integrity, or production of reactive oxygen species (ROS) and expression of neuroinflammation markers in the CNS ov+ and ov- Apo E-/- mice. Our results revealed that inhalation exposure to MVE resulted in increased demyelination and CD4+ and CD8+ T cell infiltration, associated with alterations in BBB integrity. Disruption of the BBB was evidenced by decreased tight junction (TJ) protein expression, increased matrix metalloproteinase (MMPs) activity, and increased permeability of immunoglobin (Ig) G, which were more pronounced in the MVE ov- group. Moreover, MVE-exposure also promoted ROS and neuroinflammatory signaling in the CNS of ov+ and ov- mice, compared to FA groups. To analyze mechanisms that may contribute to MVE-exposure mediated inflammatory signaling in the CNS, we examined the NF-κB signaling pathway components, namely IKK subunits, IKKα, and IKKβ, as well as RelA. MVE -exposure did not alter the expression of either IKKα and IKKβ or RelA. However, increased expression of IKKα and IKKβ mRNA was observed in both FA ov- and MVE ov- groups, indicating female sex steroid hormone signaling involvement. Investigation of hormone receptors expression revealed a reduction in cerebral ERα mRNA expression, compared to ov+ mice; however, MVE-exposure resulted in an even further decrease in expression of ERα mRNA, while ERβ and PRO …
Date: December 2020
Creator: Adivi, Anna
Partner: UNT Libraries
open access

Military Religio: Caesar's Religiosity Vindicated by Warfare

Description: Gaius Julius Caesar remains one of the most studied characters of antiquity. His personality, political career, and military campaigns have garnered numerous scholarly treatments, as have his alleged aspirations to monarchy and divinity. However, comparatively little detailed work has been done to examine his own personal religiosity and even less attention has been paid to his religion in the context of his military conquests. I argue that Caesar has wrongly been deemed irreligious or skeptical and that his conduct while on campaign demonstrates that he was a religious man. Within the Roman system of religion, ritual participation was more important than faith or belief. Caesar pragmatically manipulated the Romans' flexible religious framework to secure military advantage almost entirely within the accepted bounds of religious conduct. If strict observance of ritual was the measure of Roman religiosity, then Caesar exceeded the religious expectations of his rank and office. The evidence reveals that he was an exemplar of Roman religio throughout both the Gallic Wars (58-51BC) and the subsequent Civil Wars (49-45BC).
Date: August 2020
Creator: Adkins, Austin L
Partner: UNT Libraries

Analysis of the Cytochrome P450 and the UDP-Glucuronosyltransferases Families and Vitamin D3 Supplementation in Anoxia Survival in Caenorhabditis elegans

Description: Alteration in diet and knockdown of detoxification genes impacts the response of C. elegans to oxygen deprivation stress. I hypothesized that feeding worms a vitamin D3-supplementation diet would result in differential oxygen deprivation stress response. We used a combination of wet lab and transcriptomics approach to investigate the effect of a vitamin-D3 supplemented diet on the global gene expression changes and the anoxia response phenotype of C. elegans (Chapter 2). C. elegans genome consists of 143 detoxification genes (cyp and ugt). The presence of a significant number of genes in these detoxification families was a challenge with identifying and selecting specific cyp and ugt genes for detailed analysis. Our goal was to understand the evolution, phylogenetic, and expression of the detoxification enzymes CYPs and UGTs in C. elegans (Chapter 3). We undertook a phylogenetic and bioinformatics approach to analyze the C. elegans, detoxification family. Phylogenetic analysis provided insight into the association of the human and C. elegans xenobiotic/endobiotic detoxification system. Protein coding genes in C. elegans have been predicted to be human orthologs. The results of this work demonstrate the role of C. elegans in the identification and characterization of vitamin D3 induced alterations in gene expression profile and anoxia response phenotypes and the identification of human orthologs for the detoxification enzymes and provides insight into the gene expression pattern.
Date: December 2020
Creator: Agarwal, Sujata
Partner: UNT Libraries
Back to Top of Screen