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Role of MicroRNAs and Their Downstream Targets in Zebrafish Thrombopoiesis

Description: Previous studies have shown that human platelets and megakaryocytes carry microRNAs suggesting their role in platelet function and megakaryocyte development, respectively. However, there is limited information on microRNAs' role in zebrafish thrombopoiesis. Zebrafish thrombocytes could be used as a model to study their role in megakaryocyte maturation and platelet function because thrombocytes have both megakaryocyte features and platelet properties. In our laboratory, I identified 15 microRNAs… more
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Date: May 2023
Creator: Al Qaryoute, Ayah
Item Type: Refine your search to only Thesis or Dissertation
Partner: UNT Libraries
open access

Identification of Hox Genes Controlling Thrombopoiesis in Zebrafish

Description: Thrombocytes are functional equivalents of mammalian platelets and also possess megakaryocyte features. It has been shown earlier that hox genes play a role in megakaryocyte development. Our earlier microarray analysis showed five hox genes, hoxa10b, hoxb2a, hoxc5a, hoxc11b and hoxd3a, were upregulated in zebrafish thrombocytes. However, there is no comprehensive study of genome wide scan of all the hox genes playing a role in megakaryopoiesis. I first measured the expression levels of each of … more
Date: December 2015
Creator: Sundaramoorthi, Hemalatha
Item Type: Refine your search to only Thesis or Dissertation
Partner: UNT Libraries
open access

Blood platelets and coagulation. Annual progress report, June 1, 1975--May 31, 1976. [/sup 75/Se tracer study of effects of thrombopoietin on platelet production in mice and rabbits]

Description: The primary emphasis during the past year has been extension of studies of platelet production and demonstration of a humoral agent (i.e., thrombopoietin) that regulates the production of platelets by megakaryocytes. Incorporation of selenomethionine-/sup 75/Se (/sup 75/SeM) into platelets was used to study the effect of partially purified fractions of plasma proteins upon platelet production in normal mice and rabbits. Significant increases in levels of /sup 75/SeM in circulating platelets wer… more
Date: January 1, 1976
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
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