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Toxicology of Aurin Tricarboxylic Acid and Its Antidotal Effectiveness Against Beryllium

Description: Monkeys and dogs were used in a series of studies designed to assess the ability of aurin tricarboxylic acid (ATA) to provide protection against acute beryllium poisoning. The acute LD/sub 50/ of ATA was found to be 344 mg/kg for monkeys and 164 mg/kg for dogs. Neither species exhibited significant hematological changes when given weekly ATA doses of 25 mg/kg over an 8-month period. The lethal intravenous dose of beryllium sulfate was 0.6 mg/kg for both dogs and monkeys, but the value increased to between 1 and 3 mg/kg when given by intratracheal injection. Acute toxic effects were not observed by either intravenous or intratracheal doses of suspensions of beryllium oxide. Treatment with ATA appeared to have therapeutic value in monkeys exposed to beryllium, but no significant response was observed in dogs. (auth)
Date: December 1, 1961
Creator: King, M. E.
Partner: UNT Libraries Government Documents Department

[News Clip: Monkeys pkg]

Description: Video footage from the KXAS-TV/NBC station in Fort Worth, Texas, to accompany a news story. This story aired at 10 P.M.
Date: April 10, 1994
Creator: KXAS-TV (Television station : Fort Worth, Tex.)
Partner: UNT Libraries Special Collections

Partial protection of SIV-infected rhesus monkeys against superinfection with a heterologous SIV isolate

Description: Although there is increasing evidence that individuals already infected with human immunodeficiency virus type 1 (HIV-1) can be infected with a heterologous strain of the virus, the extent of protection against superinfection conferred by the first infection and the biologic consequences of superinfection are not well understood. We explored these questions in the simian immunodeficiency virus (SIV)/rhesus monkey model of HIV-1/AIDS. We infected cohorts of rhesus monkeys with either SIVmac251 or SIVsmE660 and then exposed animals to the reciprocal virus through intrarectal inoculations. Employing a quantitative real-time PCR assay, we determined the replication kinetics of the two strains of virus for 20 weeks. We found that primary infection with a replication-competent virus did not protect against acquisition of infection by a heterologous virus but did confer relative control of the superinfecting virus. In animals that became superinfected, there was a reduction in peak replication and rapid control of the second virus. The relative susceptibility to superinfection was not correlated with CD4(+) T-cell count, CD4(+) memory T-cell subsets, cytokine production by virus-specific CD8(+) or CD4(+) cells, or neutralizing antibodies at the time of exposure to the second virus. Although there were transient increases in viral loads of the primary virus and a modest decline in CD4(+) T-cell counts after superinfection, there was no evidence of disease acceleration. These findings indicate that an immunodeficiency virus infection confers partial protection against a second immunodeficiency virus infection, but this protection may be mediated by mechanisms other than classical adaptive immune responses.
Date: January 1, 2009
Creator: Korber, Bette
Partner: UNT Libraries Government Documents Department

[News Script: Chimpanzee]

Description: Script from the WBAP-TV/NBC station in Fort Worth, Texas, relating a news story. This story aired at 12:00pm.
Date: April 7, 1969, 12:00 p.m.
Creator: WBAP-TV (Television station : Fort Worth, Tex.)
Partner: UNT Libraries Special Collections

[News Clip: Ape House]

Description: B-roll video footage from the KXAS-TV/NBC station in Fort Worth, Texas, to accompany a news story.
Date: April 25, 1979, 6:00 p.m.
Creator: KXAS-TV (Television station : Fort Worth, Tex.)
Partner: UNT Libraries Special Collections

[News Script: Monkey]

Description: Script from the WBAP-TV/NBC station in Fort Worth, Texas, covering a news story about Zip, a roller skating six year old ape, promoting a new toy.
Date: June 9, 1957
Creator: WBAP-TV (Television station : Fort Worth, Tex.)
Partner: UNT Libraries Special Collections

Evolutionary expansion and divergence in a large family of primate-specific zinc finger transcription factor genes

Description: Although most genes are conserved as one-to-one orthologs in different mammalian orders, certain gene families have evolved to comprise different numbers and types of protein-coding genes through independent series of gene duplications, divergence and gene loss in each evolutionary lineage. One such family encodes KRAB-zinc finger (KRAB-ZNF) genes, which are likely to function as transcriptional repressors. One KRAB-ZNF subfamily, the ZNF91 clade, has expanded specifically in primates to comprise more than 110 loci in the human genome, yielding large gene clusters in human chromosomes 19 and 7 and smaller clusters or isolated copies at other chromosomal locations. Although phylogenetic analysis indicates that many of these genes arose before the split between old world monkeys and new world monkeys, the ZNF91 subfamily has continued to expand and diversify throughout the evolution of apes and humans. The paralogous loci are distinguished by sequence divergence within their zinc finger arrays indicating a selection for proteins with different DNA binding specificities. RT-PCR and in situ hybridization data show that some of these ZNF genes can have tissue-specific expression patterns, however many KRAB-ZNFs that are near-ubiquitous could also be playing very specific roles in halting target pathways in all tissues except for a few, where the target is released by the absence of its repressor. The number of variant KRAB-ZNF proteins is increased not only because of the large number of loci, but also because many loci can produce multiple splice variants, which because of the modular structure of these genes may have separate and perhaps even conflicting regulatory roles. The lineage-specific duplication and rapid divergence of this family of transcription factor genes suggests a role in determining species-specific biological differences and the evolution of novel primate traits.
Date: September 28, 2005
Creator: Hamilton, A T; Huntley, S; Tran-Gyamfi, M; Baggott, D; Gordon, L & Stubbs, L
Partner: UNT Libraries Government Documents Department

Chimpanzee chromosome 12 is homologous to human chromosome 2q

Description: Most of the 46 human chromosomes find their counterparts in the 48 chimpanzee chromosomes except for chromosome 2 which has been hypothesized to have been derived from a centric fusion of two chimpanzee acrocentric chromosomes. These two chromosomes correspond to the human chromosomes 2p and 2g. This conclusion is based primarily on chromosome banding techniques, and the somatic cell hybridization technique has also been used. (HLW)
Date: January 1, 1977
Creator: Sun, N. C.; Sun, C. R.Y. & Ho, T.
Partner: UNT Libraries Government Documents Department

Chimpanzee chromosome 13 is homologous to human chromosome 2p

Description: Similarities between human and chimpanzee chromosomes are shown by chromosome banding techniques and somatic cell hybridization techniques. Cell hybrids were obtained from the chimpanzee lymphocyte LE-7, and the Chinese hamster mutant cell, Gal-2. Experiments showed that the ACPL, MDHs, and Gal-Act genes could be assigned to chimpanzee chromosome 13, and since these genes have been assigned to human chromosme 2p, it is suggested that chimpanzee chromosome 13 is homologous to human chromosome 2p. (HLW)
Date: January 1, 1977
Creator: Sun, N. C.; Sun, C. R.Y. & Ho, T.
Partner: UNT Libraries Government Documents Department

[News Clip: Monkeys]

Description: Video footage from the KXAS-TV/NBC station in Fort Worth, Texas, to accompany a news story. Story aired at 6pm.
Date: July 7, 1995, 6:00 p.m.
Creator: KXAS-TV (Television station : Fort Worth, Tex.)
Partner: UNT Libraries Special Collections

[News Clip: Ape picnic]

Description: Video footage from the KXAS-TV/NBC station in Fort Worth, Texas, to accompany a news story. This story aired at 6:00 P.M.
Date: 1980
Creator: KXAS-TV (Television station : Fort Worth, Tex.)
Partner: UNT Libraries Special Collections

[News Script: Monkey]

Description: Script from the WBAP-TV/NBC station in Fort Worth, Texas, covering a news story about a squirrel monkey named "O No" that escaped its enclosure at the Dallas Zoo.
Date: June 29, 1958
Creator: WBAP-TV (Television station : Fort Worth, Tex.)
Partner: UNT Libraries Special Collections

[News Script: Monkey]

Description: Script from the WBAP-TV/NBC station in Fort Worth, Texas, covering a news story about the Fort Worth Zoo creating an "animal to animal" program at Forest Park in Fort Worth, Texas.
Date: February 21, 1962
Creator: WBAP-TV (Television station : Fort Worth, Tex.)
Partner: UNT Libraries Special Collections

[News Script: Gibbon]

Description: Script from the WBAP-TV/NBC station in Fort Worth, Texas, covering a news story about the birth of a monkey at the Fort Worth's Forest Park zoo.
Date: December 29, 1963
Creator: WBAP-TV (Television station : Fort Worth, Tex.)
Partner: UNT Libraries Special Collections

[News Script: Roaming Rhesus]

Description: Script from the WBAP-TV station in Fort Worth, Texas, covering a news story about Jocko, the Roaming Rhesus, escaping from his home.
Date: April 12, 1951
Creator: WBAP-TV (Television station : Fort Worth, Tex.)
Partner: UNT Libraries Special Collections