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Plant Phenotype Characterization System

Description: This report is the final scientific report for the DOE Inventions and Innovations Project: Plant Phenotype Characterization System, DE-FG36-04GO14334. The period of performance was September 30, 2004 through July 15, 2005. The project objective is to demonstrate the viability of a new scientific instrument concept for the study of plant root systems. The root systems of plants are thought to be important in plant yield and thus important to DOE goals in renewable energy sources. The scientific … more
Date: September 9, 2005
Creator: McDonald, Daniel W & Michaels, Ronald B
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
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Rapid emergence of hepatitis C virus protease inhibitor resistance is expected

Description: Approximately 170 million people worldwide are infected with hepatitis C virus (HCV). Current therapy, consisting of pegylated interferon (PEG-IFN) and ribavirin (RBV), leads to sustained viral elimination in only about 45% of patients treated. Telaprevir (VX-950), a novel HCV NS3-4A serine protease inhibitor, has demonstrated substantial antiviral activity in patients with chronic hepatitis C genotype 1 infection. However, some patients experience viral breakthrough during dosing, with drug re… more
Date: January 1, 2009
Creator: Rong, Libin; Perelson, Alan S & Ribeiro, Ruy M
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
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Systems Biology Knowledgebase for a New Era in Biology A Genomics:GTL Report from the May 2008 Workshop

Description: Biology has entered a systems-science era with the goal to establish a predictive understanding of the mechanisms of cellular function and the interactions of biological systems with their environment and with each other. Vast amounts of data on the composition, physiology, and function of complex biological systems and their natural environments are emerging from new analytical technologies. Effectively exploiting these data requires developing a new generation of capabilities for analyzing an… more
Date: March 1, 2009
Creator: Gregurick, S.; Fredrickson, J. K. & Stevens, R.
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
open access

High quality copy number and genotype data from FFPE samples using Molecular Inversion Probe (MIP) microarrays

Description: A major challenge facing DNA copy number (CN) studies of tumors is that most banked samples with extensive clinical follow-up information are Formalin-Fixed Paraffin Embedded (FFPE). DNA from FFPE samples generally underperforms or suffers high failure rates compared to fresh frozen samples because of DNA degradation and cross-linking during FFPE fixation and processing. As FFPE protocols may vary widely between labs and samples may be stored for decades at room temperature, an ideal FFPE CN te… more
Date: February 24, 2009
Creator: Wang, Yuker; Carlton, Victoria E. H.; Karlin-Neumann, George; Sapolsky, Ronald; Zhang, Li; Moorhead, Martin et al.
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
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A new sieving matrix for DNA sequencing, genotyping and mutation detection and high-throughput genotyping with a 96-capillary array system

Description: Capillary electrophoresis has been widely accepted as a fast separation technique in DNA analysis. In this dissertation, a new sieving matrix is described for DNA analysis, especially DNA sequencing, genetic typing and mutation detection. A high-throughput 96 capillary array electrophoresis system was also demonstrated for simultaneous multiple genotyping. The authors first evaluated the influence of different capillary coatings on the performance of DNA sequencing. A bare capillary was compare… more
Date: November 8, 1999
Creator: Gao, David
Item Type: Refine your search to only Thesis or Dissertation
Partner: UNT Libraries Government Documents Department
open access

Evaluation of the Reproductive Success of Wild and Hatchery Steelhead in Hatchery and Natural and Hatchery Environments : Annual Report for 2008.

Description: This report summarizes the field, laboratory, and analytical work from December 2007 through November 2008 on a research project that investigates interactions and comparative reproductive success of wild and hatchery origin steelhead (Oncorhynchus mykiss) trout in Forks Creek, a tributary of the Willapa River in southwest Washington. First, we continued to successfully sample hatchery and wild (i.e., naturally spawned) adult and wild smolt steelhead at Forks Creek. Second, we revealed microsat… more
Date: December 5, 2008
Creator: Quinn, Thomas P.; Seamons, todd; Hauser, Lorenz & Naish, Kerry
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
open access

Genomic analysis of the symbiotic marine crenarchaeon, Cenarchaeumsymbiosum

Description: Crenarchaea are ubiquitous and abundant microbial constituents of soils, sediments, lakes and ocean waters, yet relatively little is known about their fundamental evolutionary, ecological, and physiological properties. To better describe the ubiquitous nonthermophilic Crenarchaea, we analyzed the genome sequence of one representative, the uncultivated sponge symbiont, Cenarchaeum symbiosum. C. symbiosum genotypes coinhabiting the same host partitioned into two dominant populations, correspondin… more
Date: June 24, 2006
Creator: Hallam, Steven J.; Konstantinidis, Konstantinos T.; Brochier, Celine; Putnam, Nik; Schleper, Christa; Watanabe, Yoh-ichi et al.
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
open access

Functional genomics, an integrated approach. Final report for the Trieste component

Description: Phage display offers the possibility of selecting polypeptides (and the genes which encode them) from libraries of 10 billion or more different polypeptides on the basis of their abilities to bind target proteins and subdomains. The general principle of phage display relies on the coupling of phenotype and genotype in the phage. The specific aims of this project were threefold: (1) to produce a large phagemid antibody library; (2) to develop a general method for deriving antibodies against the … more
Date: November 1, 1999
Creator: Bradbury, Andrew
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
open access

Characterization of chemically modified hyperthermophilic enzymes for chemical syntheses and bioremediation reactions. 1998 annual progress report

Description: 'Remediation processes frequently involve species possessing limited solubility in water. The authors are interested in novel strategies that use molecularly-engineered enzymes with enhanced activity and stability for the remediation of recalcitrant compounds in organic media. Organic biocatalysis may be motivated by the nature of the substrate itself, or by augmented mass transport, ease of product recovery, or novel reaction pathways afforded by the organic solvent. However, naturally-occurri… more
Date: June 1, 1998
Creator: Kaufman, E. N. & Adams, M. W. W.
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
open access

Characterization of chemically modified enzymes for bioremediation-reactions. 1997 annual progress report

Description: 'Many, if not most, biological transformation reactions of interest to US Department of Energy (DOE) site remediation involve substrates that are only sparingly soluble in aqueous environments. Hence, destruction of these recalcitrant and toxic materials would benefit tremendously if their degradation could be performed in nonaqueous environments. Organic biocatalysis may be motivated by the nature of the substrate itself, augmented mass transport, ease of product recovery, or novel reaction pa… more
Date: September 1, 1997
Creator: Kaufman, E. N. & Adams, M. W. W.
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
open access

A novel biomarker for beryllium sensitization in humans. 1998 annual progress report

Description: 'Beryllium reactive T-lymphocytes can be used as an indicator of sensitization. Traditionally, their presence is detected by an in vitro proliferation assay. However, this test is capricious (results varying from day to day in the same laboratory) and insensitive (rarely positive before clinical symptoms ). The objective of this project is to obtain and characterize beryllium reactive T-cells from peripheral blood using the hprt T-cell mutation assay. T-cells are selected on the basis of their … more
Date: June 1, 1998
Creator: Albertini, R.J.
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
open access

A novel biomarker for beryllium sensitization in humans. 1997 annual progress report

Description: 'Overall, this project is designed to identify the beryllium reactive T-cell clones that are proliferating in vivo in individuals sensitized to beryllium. The basic method for identifying such clones is the hprt T-cell mutation assay. The rationale is that in vivo proliferating T-lymphocytes are more likely to undergo hprt mutations and/or be included in hprt mutant fractions of T-cells isolated from peripheral blood. T-lymphocytes isolated as hprt mutants from beryllium sensitized individuals … more
Date: January 1, 1997
Creator: Albertini, R.J.
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
open access

Putting Tumors in Context

Description: The interactions between cancer cells and their micro- and macroenvironment create a context that promotes tumor growth and protects it from immune attack. The functional association of cancer cells with their surrounding tissues forms a new 'organ' that changes as malignancy progresses. Investigation of this process might provide new insights into the mechanisms of tumorigenesis and could also lead to new therapeutic targets. Under normal conditions, ORGANS are made up of TISSUES that exchange… more
Date: October 1, 2001
Creator: Bissell, Mina & Radisky, Derek
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
open access

Thermal Properties of Starch From New Corn Lines as Impacted by Environment and During Line Development

Description: The objectives of this research were to further characterize exotic by adapted corn inbreds by studying the impact of environment on their starch thermal properties, and investigating the development of starch thermal properties during kernel maturation by using differential scanning calorimetry (DSC). A method to expedite identification of unusual starch thermal traits was investigated by examining five corn kernels at a time, instead of one kernel, which the previous screening methods used. C… more
Date: December 12, 2003
Creator: Lenihan, Elizabeth M.
Item Type: Refine your search to only Thesis or Dissertation
Partner: UNT Libraries Government Documents Department
open access

Behavioral versus genetic determination of lipoproteins andidentical twins discordant for exercise

Description: Lipoprotein and weight differences between vigorously active and sedentary MZ twins are used to: (1) estimate the effects of training while controlling for genotype; (2) estimate genetic concordance in the presence of divergent lifestyles.
Date: June 1, 2004
Creator: Williams, Paul T.; Blanche, Patricia J. & Krauss, Ronald M.
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
open access

Genetic characterization of Lophopyrum elongatum salt tolerance and associated ion regulation as expressed in bread wheat. Final technical report

Description: Lophopyrum elongatum is a highly salt-tolerant relative of wheat. Its salt tolerance is partially expressed in the amphiploid from a cross between wheat cv. Chinese Spring and L. elongatum. Genetic studies showed that the tolerance of gradually imposed salt stress is controlled by L. elongatum chromosomes 3E, 4E, 5E, and 7E and the tolerance of suddenly imposed salt stress by chromosomes 3E, 5E, 6E, and 7E. In wheat, rye, barley, and Dasypyrum, chromosomes of the same homoeologous groups, 3, 5,… more
Date: October 7, 1997
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
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Mechanisms and genetic control of interspecific crossing barriers in Lycopersicon. Final report

Description: Deficiency of Lycopersicon esculentum allele (E) was observed from the RFLP and isozyme data of the F{sub 2} populations derived from the cross L. esculentum x L. pennellii. The genome composition of the F{sub 2} populations containing L. pennellii cytoplasm (F{sub 2}{sup Lp4}) has a lower proportion of the homozygous L. pennellii (PP) genotypes and a higher proportion of heterozygote (EP) genotypes than that of the F{sub 2} populations containing L. esculentum cytoplasm (F{sub 2}{sup Le}). A l… more
Date: April 30, 1997
Creator: Mutschler, M.A.
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
open access

A theoretical analysis of population genetics of plants on restored habitats

Description: Seed and propagules used for habitat restoration are not likely to be closely adapted to local site conditions. Rapid changes of genotypes frequencies on local microsites and/or microevolution would allow plants to become better adapted to a site. These same factors would help to maintain genetic diversity and ensure the survival of small endangered populations. The authors used population genetics models to examine the selection of genotypes during establishment on restored sites. Vegetative s… more
Date: July 1, 1997
Creator: Bogoliubov, A.G. & Loehle, C.
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
open access

Human genetic marker for resistance to radiations and chemicals. 1998 annual progress report

Description: 'The broad objective of the project is to understand the molecular basis for the response of cells to radiations and chemicals, with the pragmatic goal of being able to identify human subpopulations that are exceptionally sensitive to DNA damaging agents. The project focuses on HRAD9, a human orthologue of the fission yeast Schizosaccharomyces pombe gene rad9. S. pombe rad9::ura4+ mutant cells are highly sensitive to ionizing radiation, UV and many chemicals, such as the DNA synthesis inhibitor… more
Date: June 1, 1998
Creator: Lieberman, H.B.
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
open access

Human genetic marker for resistance to radiations and chemicals. 1997 annual progress report

Description: 'The specific aims listed in the original application will essentially be pursued as indicated. The major goal of the grant is to characterize a human homologue of the fission yeast Schizosaccharomyces pombe rad9 checkpoint control, radioresistance and chemoresistance gene, which is called HRAD9. The purpose is to gain information about the gene, including its structure and function, such that it can potentially be developed as a human genetic marker indicative of hypersensitivity to the delete… more
Date: January 1, 1997
Creator: Lieberman, H.B.
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
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