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Clinical Research: NIH Has Implemented Key Provisions of the Clinical Research Enhancement Act

Description: A letter report issued by the General Accounting Office with an abstract that begins "Clinical research is critical for the development of strategies for the prevention, diagnosis, prognosis, treatment, and cure of diseases. Clinical research has been defined as patient-oriented research, epidemiologic and behavioral studies, and outcomes research and health services research. The National Institutes of Health (NIH) is the principal federal agency that funds clinical research supporting individual clinical investigators, clinical trials, general and specialized clinical research centers, and clinical research training. For many years, there have been concerns that clinical research proposals are viewed less favorably than basic research during the peer review process at NIH and that clinical research has not received its fair share of NIH funding. In November 2000, the Clinical Research Enhancement Act was enacted to address some of these concerns. NIH reports that it has increased its financial support of clinical research and that spending on clinical research has kept pace with total NIH research spending. NIH has taken some steps to improve its peer review of clinical research applications. The Center for Scientific Review recently added two new peer review study sections for the review of clinical research applications--one for clinical cardiovascular science and other for clinical oncology. NIH has increased its support of general clinical research centers, as required by the act, although the program has grown more slowly than NIH's overall estimated expenditures on clinical research. NIH has established the four clinical research career enhancement award programs mandated by the act. Three of these programs have been implemented, and they support new and midcareer clinical investigators and institutional clinical research teaching programs. The fourth program is designed to support graduate training in clinical investigation. NIH has initiated a new extramural loan repayment program specifically for clinical investigators as required by ...
Date: September 18, 2002
Creator: United States. General Accounting Office.
Partner: UNT Libraries Government Documents Department

Comments on "A Neurobiological Model for Near-Death Experiences"

Description: Article presenting commentary on a neurobiological model proposed by Juan C. Saavedra-Aguilar and Juan S. Gómez-Jeria, which discusses the clinical similarities between temporal lobe seizures and near-death experiences (NDEs). Dr. Morse presents notes regarding his own research with colleagues based on similarities with various neurotransmitters.
Date: Summer 1989
Creator: Morse, Melvin L.
Partner: UNT Libraries

Participant Perspectives: Investigating the Experience of Low-Income Schizophrenics in Clinical Research Trials

Description: The continued investigation into the experiences of individuals with schizophrenia who participate in biomedical research trials is necessary in order to understand participants’ perspectives, motivations, attitudes, values, and beliefs. As important stakeholders in the clinical research process, participant feedback is significant and can help shed light on, not only their experiences, but also deepen understandings when it comes to clinical trial participants’ perceptions of informed consent and personal autonomy. Conducting ethical research demands the exploration of these issues and specifically targeting this vulnerable group helped to address a gap in the literature. This study was conducted for InSite Clinical Research and gathered data in the form of in-depth semi-structured interviews and a short survey instrument with 20 low-income adults diagnosed with schizophrenia that participate in clinical research trials. Findings indicate overall positive research experiences, with motivations aligning with previous research when it comes to trial participation including: altruism, personal benefit, access to medications, financial incentives, and psychosocial treatment. Learning about their illness and themselves, autonomy, and debriefing were also particularly important within this group. Unique to this sample were findings of friendship. Trust in the research staff was identified as a major underlying value and shaping factor impacting informed consent decisions. These conclusions have implications for recruitment and informed consent practices at InSite Clinical Research.
Date: May 2015
Creator: Green, Asha M.
Partner: UNT Libraries

Clinical Approaches to the Out-of-Body Experience

Description: Abstract: The author reviews aspects of the out-of-body experience (OBE) related to psychic experiences and personality traits, and describes a continuum of experiences of altered mind/body perception, from the prototypical OBE on the healthy end to schizophrenia and organic brain syndromes on the other end. The impact of the OBE on the individual's life is described, with suggestions for a psychoeducational approach to the clinical management of the patient with an OBE to allow maximum growth from the consciousness-expanding effects of the experience.
Date: Autumn 1989
Creator: Twemlow, Stuart W.
Partner: UNT Libraries

[News Clip: AMA president]

Description: Video footage from the WBAP-TV station in Fort Worth, Texas to accompany a story about Dr. Edward R. Annis of Miami, president of the American and World Medical Associations, who is in Fort Worth to address the Tarrant County Chapter of Texas Manufacturers Association. In this story, Dr. Annis criticizes legislation that results in decreased clinical research related to the development of new prescription drugs and the FDA's removal of the antidepressant medication Parnate from the market.
Date: May 28, 1964
Creator: WBAP-TV (Television station : Fort Worth, Tex.)
Partner: UNT Libraries Special Collections