Diphenyloxazole Metabolism by Aryl Hydrocarbon Hydroxylase
Description:
2,5-Diphenyloxazole (PPO) was tested as a potential alternate inducer for the aryl hydrocarbon hydroxylase (AHH) system. Its apparent lack. of carcinogenicity and toxicity provide a possible system for investigation of enzyme systems related to chemical carcinogenesis without exposure of the researcher to potent carcinogenic compounds. These studies found PPO to be an inducer of AHH in cultured human lymphocytes. When PPO was utilized as a substrate for the AHH assay system, the major metabolit…
more
Date:
December 1976
Creator:
Abreu, Mary E.
Partner:
UNT Libraries