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A Comparative Study of Four Genealogies to Determine Predisposition to Cancer

Description: This study was made in an effort first, to determine the mode of transmission of the inheritance of a predisposition to cancer as revealed through the analyses of four separate human genealogies, and second, to make a comparative study of the genealogies to determine whether the mode of transmission is the same.
Date: 1941
Creator: Andrew, Vivian Wilson
Partner: UNT Libraries

Caring for Cancer: Understanding the Access and Perceptions of Psychosocial Cancer Services in North Texas

Description: It is estimated that nearly 14.5 million Americans are living with cancer today. A commonly overlooked component to quality cancer care, as defined by the Institute of Medicine, is the role of psychological and social support. Better known as psychosocial support, these needs reflect a broad spectrum of obstacles or assets in an individual’s personal life that may help or hinder their healing experience. Some psychosocial examples include coping skills, transportation to medical appointments, or appropriate knowledge to mitigate the physical impacts of the cancer process. Research has shown that by addressing these potential needs, a better health outcome may be achieved for cancer patients. Through participant observation at local psychosocial service establishments and through semi-structured interviews with service providers and adults diagnosed with cancer living in the Dallas-Fort Worth region, this thesis research seeks to explore how local cancer patients are learning of psychosocial services available to them, what barriers may exist in accessing these services, and what individuals may be doing to address their psychosocial needs, both formally or informally. Results yielded recommendations for local psychosocial providers to adjust their marketing of services and kinds of services offered as well as yielded recommendations for future academic research.
Date: December 2014
Creator: Quirk, Lisa Erin
Partner: UNT Libraries

Identifying the Level of Prognostic Information Desired by People with Cancer

Description: The study explored whether certain factors might be used to distinguish between people with cancer who do or do not want detailed information about their disease progress, do or do not want to be informed if their disease is no longer considered curable, and who do or do not want an estimation of life expectancy if their disease is no longer considered curable. The factors included whether an individual has an internal versus external locus of control, uses an active coping strategy or a planning coping strategy, the level of spirituality, and age. Participants consisted of 51 people with cancer from a cancer center in the state of Washington. Results indicated that 98% wanted detailed information about their disease progress, 94% wanted to be informed if their disease was no longer considered curable, and 78% wanted an estimation of life expectancy if their disease was no longer considered curable. Due to the majority of the participants endorsing the need for prognostic information none of the factors (e.g. coping strategies, locus of control, spirituality) were able to predict the information needs of the patients with cancer. Clinical implications of this study suggest that physicians have an ongoing, open dialogue with their patients about their prognostic information needs. The dialogue might be especially important for patients undergoing active treatment for cancer, since it could affect treatment decisions.
Date: August 2010
Creator: Mallory, Laurel J.
Partner: UNT Libraries

Human alpha 1-acid glycoprotein: a study of genetic variation

Description: Human Alpha 1-acid Glycoprotein (AAG) was analyzed quantitavely and qualityatively for differences which could be associated with oncogenesis. Levels of seru, AAG were elevated in most mlignancies, particularly in malignant melanomas, malignant myelomas, and in solid tumors of the lung, kidney, colon, or other organs.
Date: August 1983
Creator: Thaxton, E. Simone
Partner: UNT Libraries

Preventing Cancer

Description: Poster presentation for the 2012 University Scholars Day at the University of North Texas discussing research on preventing, rather than curing, cancer.
Date: April 19, 2012
Creator: O'Hara, Matthew Patrick & Eve, Susan Brown
Partner: UNT Honors College

Final Report DOE Grant# DE-FG02-98ER62592: Second Cancers, Tumor p53, and Archaea Research

Description: The Northeast Regional Cancer Institute conducted cancer surveillance in Northeast Pennsylvania using data from the institute’s population-based regional cancer registry and the Pennsylvania Cancer Registry. The results of this surveillance have been used to set priorities for research and outreach activities at the Cancer Institute and selected results have been reported to medical professionals at member hospitals and in the community. One consistent observation of this surveillance was that colorectal cancer was unusually common in Northeast Pennsylvania; incidence was approximately 25% higher than the rate published for NCI’s Surveillance Epidemiology and End Results (SEER) Program. In addition, death rates form colorectal cancer in several counties in this region were above the 90Th percentile for colorectal cancer mortality in the United States. As a result of these observations, several activities have been developed to increase awareness of colorectal cancer and the value of screening for this cancer in both the lay and medical communities. Funding from this grant also provided support for a population-based study of cancer risk factors, screening practices, and related behaviors. This project continues beyond the termination of the present grant with funding from other sources. This project gathers data from a representative sample of adults residing in a six county area of Northeast Pennsylvania. Analyses conducted to date of the established risk factors for colorectal cancer have not revealed an explanation for the high incidence of this cancer in this population.
Date: January 14, 2006
Creator: Samuel M. Lesko, MD, MPH
Partner: UNT Libraries Government Documents Department

ALKBH7 Variant Related to Prostate Cancer Exhibits Altered Substrate Binding

Description: This article reports a targeted search for single nucleotide polymorphisms (SNPs) and functional impact characterization of human ALKBH family dioxygenases related to prostate cancer.
Date: September 23, 2016
Creator: Walker, Alice R.; Silvestrov, Pavel; Müller, Tina A.; Podolsky, Robert H.; Dyson, Gregory; Hausinger, Robert P. et al.
Partner: UNT College of Arts and Sciences

An Investigation of the Effect of Normative Systems on an Empirical Variable

Description: This investigation is concerned, with the problem of the normative constraints upon scientific research within the broad theoretical framework of the sociology of knowledge, i.e., the contention that knowledge is functionally related to the social system. The concepts "knowledge" and "Social system" are open to wide interpretation; however, in this study knowledge refers to an empirically verifiable variable and the social system is synonomous with the normative system.
Date: December 1971
Creator: Sizemore, Mark T.
Partner: UNT Libraries

Targeted abrogation of diverse signal transduction cascades by emodin for the treatment of inflammatory disorders and cancer

Description: Article on the targeted abrogation of diverse signal transduction cascades by emodin for the treatment of inflammatory disorders and cancer.
Date: December 1, 2013
Creator: Shrimali, Deepti; Shanmugam, Muthu K.; Kumar, Alan Prem; Zhang, Jingwen; Tan, Benny K-H; Ahn, Kwang Seok et al.
Partner: UNT College of Arts and Sciences

Targeted inhibition of tumor proliferation, survival, and metastasis by pentacyclic triterpenoids: Potential role in prevention and therapy of cancer

Description: Article on the targeted inhibition of tumor proliferation, survival, and metastasis by pentacyclic triterpenoids and the potential role in prevention and therapy of cancer.
Date: July 28, 2012
Creator: Shanmugam, Muthu K.; Nguyen, An H.; Kumar, Alan Prem; Tan, Benny K-H & Sethi, Gautam
Partner: UNT College of Arts and Sciences

Data Mining Techniques for Predicting Breast Cancer Survivability Among Women in the United States

Description: Poster for the 2014 UNT Graduate Exhibition in the Computer Science and Information Technology category. This poster discusses data mining techniques for predicting breast cancer survivability among women in the United States.
Date: March 1, 2014
Creator: Alshammari, Sultanah M.; Shah, Tawfiq M. & Huang, Yan
Partner: UNT College of Engineering

Biocompatible Graphene-based Growth of Cancer Cells: A Work in Progress

Description: Poster presentation for the 2012 University Scholars Day at the University of North Texas. This poster discusses research on the biocompatible graphene-based growth of cancer cells. Graphene is made of a single layer of carbon atoms. Recently is has been used to successfully differentiate stem cells in neural cells.
Date: April 19, 2012
Creator: Parks, Melissa & Verrill, Diane
Partner: UNT Honors College

Early Detection of Melanoma and other Cancers in Residents of Nevada

Description: The overall goal of this project was to develop simple and inexpensive tests to screen for the presence of early stage cancer in the residents of Nevada with a particular emphasis on the membership of the Hotel Employee Restaurant Employee International Union (HEREIU) in Las Vegas. Our specific goals were: 1) to develop a clinical database of individuals with cancer and to create a biological specimen Collection and Storage Systems (the NVCI bio-bank); 2) to initiate screening of individuals for proteomic markers indicating susceptibility to or the presence of specific cancers, e.g. breast, ovarian, prostate and bladder. In addition, we proposed the implementation of novel digital imaging technologies to detect melanoma; 3) to genotype blood samples from individuals who consent to participate in IRB approved research studies using a high throughput single nucleotide polymorphisms (SNP) method based on optical thin-film biosensor chip technology; and 4) to conduct biostatistical analysis of clinical, demographic, genetic, proteomic and digital imaging data to stratify the population cohort into relative risk groups for cancers that are prevalent in Nevada.
Date: October 30, 2006
Creator: David Ward, PhD and Nicholas Vogelzang, MD
Partner: UNT Libraries Government Documents Department

Depression, Anxiety, Self-Esteem, and Coping in Children and Adolescents Newly Diagnosed with Cancer and Children and Adolescents on Cancer Treatment for a Period of Seven Months or Longer

Description: Differences in self-reported depression, anxiety, self-esteem, and coping were evaluated in two groups of pediatric oncology patients: newly diagnosed (less than six months post-diagnosis) (n=5) and patients on cancer treatment for seven months or longer (n=5). Participants (6 males, 4 females, ages 7-17 years) completed the Children's Depression Inventory (CDI), the State-Trait Anxiety Inventory for Children (STAIC), and the Culture-Free Self-Esteem Inventory (CFSEI-2); nine of the ten participants discussed in a semi-structured interview their personal experiences and feelings about having cancer. Although the newly diagnosed group had a higher mean score on the CDI than the 7 months or greater group, the difference was not significant (p = .054). The newly diagnosed group also had higher mean state and trait anxiety scores on the STAIC, indicating higher anxiety levels, and a slightly lower CFSEI-2 mean score, indicating slightly lower self-esteem than the 7 months or greater group, but differences were not at a statistically significant level (p>.05).
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Date: May 2000
Creator: Jones, Tracy L.
Partner: UNT Libraries

Comparative Models of the Impact of Social Support on Psychological Distress in Cancer Patients

Description: This study tested the relationship between Social Support, Psychological Distress, and Illness Stress in individuals who report cancer as a health condition. This study was based on archival data obtained from the Wave 1 of the Health and Retirement Study (HRS). The HRS provides a nationally representative sample of individuals aged 51 to 61 in 1992 and their spouses. The study sample was limited to cancer patients with a spouse or partner (n = 503). A structural equation modeling analysis procedure was used to test the theoretical models. Measures of social support were limited to variables assessing the participant's satisfaction with social support. Evidence was found for the Stress Prevention and the Support Deterioration models. This is congruent with previous research using measures of social support perception. Both the Stress Prevention and the Support Deterioration models predict a negative relationship between Illness Stress and Social Support. In addition, a univariate analysis of variance was used to test the stress buffering model. Similarly to other studies measuring the individual's degree of integration, or its perception, in the social network, the present research supported the only the Main Effect model and not the Stress Buffering model.
Date: May 2000
Creator: Forjaz, Maria João Bettencourt Pereira
Partner: UNT Libraries

Comparing Quality of Life: American and Portuguese Cancer Patients with Hematological Malignancies

Description: The purpose of this study is to investigate the differences and similarities of quality of life (QoL) in American and Portuguese cancer patients with hematological malignancies as well as the robustness of the measures cross-culturally. Portuguese participants were 98 patients and 49 accompanying persons and the American participants were 55 patients and 22 accompanying persons. Fifty (Portuguese sample) to 40% (American sample) of the patients came with an accompanying person who answered the questionnaire concerning the patient's QoL. The two cultural groups were characterized in terms of QoL (measured by the SF-36 and the FLIC), social support (Social Support Scale), socio-demographic and clinical variables. Portuguese patients reported a higher QoL. However, this result could be attributable to the fact that the two cultural samples differ in socio-economic status. The measures seem to be comparable for the Portuguese and American samples, at least in what concerns reliability and concurrent validity.
Date: December 1997
Creator: Forjaz, Maria João
Partner: UNT Libraries

Unconventional Cancer Treatments

Description: This report describes the unconventional cancer treatments that are most used by U.S. cancer patients; it describes the way in which people find out about them and how much they pay for them; reviews the claims made for them and the information base in support of the claims; suggests possible ways of generating valid information about their safety and effectiveness; and presents the legal issues surrounding unconventional treatments that have brought civil and criminal litigation to bear on the subject.
Date: September 1990
Creator: United States. Congress. Office of Technology Assessment.
Partner: UNT Libraries Government Documents Department