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Evaluation of the Quick Inventory of Depressive Symptomatology - Self-Report (QIDS-SR) in a spinal cord injury population.

Description: Spinal cord injury (SCI) is an acute and devastating event that results in significant and permanent life changes for the individuals who are injured, as well as their families and friends. Depression has received more attention from clinicians and researchers than any other psychological issue among persons with SCI. Measurement of depression in this population has a variety of methodological issues, including inconsistent assessments used (self-report versus clinical interviews), varying definitions of depression, inclusion and exclusion of physical symptoms in the assessment process, and use of measures that do not represent DSM-IV criteria for major depressive disorder. The primary goal of this study was to evaluate the Quick Inventory of Depressive Symptomatology - Self-Report (QIDS-SR) and provide descriptive analyses of this measure with persons with SCI. Results showed that somatic symptoms were more frequently endorsed than psychological symptoms in this population. Additionally, scores on the QIDS-SR were significantly associated with a depression diagnosis in the patient's medical chart. However, QIDS-SR scores were not found to be correlated inversely with quality of life scores as predicted. The QIDS-SR was shown to have good internal consistency and convergent validity with patients with SCI. However, it failed to demonstrate construct validity. The QIDS-SR has the potential to be a valid measure with this population and further analysis of the psychometric properties with patients with SCI is warranted.
Date: August 2008
Creator: Reed, Kristin
Partner: UNT Libraries

Identifying Changes in Resilience during Rehabilitation from a Spinal Cord Injury

Description: The study purposes were to identify changes in resilience, satisfaction with life (SWL), depression, spirituality, and functional independence (FI) and to examine the relationship between these variables, during the inpatient rehabilitation for a spinal cord injury (SCI). The sample included 42 individuals with a SCI, 33 males and 9 females, who were inpatients with a mean stay of 52 days (SD = 15.78). A repeated measures design was employed with questionnaires completed at three times during rehabilitation. Results indicated that there were significant changes in depression, satisfaction with life, spirituality, and FI during inpatient rehabilitation. Findings also indicated significant correlations between resilience, SWL, spirituality, and depression. Future studies developing interventions, and examining factors that predict resilience could help build resilience and may improve rehabilitation outcomes.
Date: May 2008
Creator: White, Brian Dale
Partner: UNT Libraries

LARP Long Nb3Sn Quadrupole Design

Description: A major milestone for the LHC Accelerator Research Program (LARP) is the test, by the end of 2009, of two 4m-long quadrupole magnets (LQ) wound with Nb{sub 3}Sn conductor. The goal of these magnets is to be a proof of principle that Nb{sub 3}Sn is a viable technology for a possible LHC luminosity upgrade. The design of the LQ is based on the design of the LARP Technological Quadrupoles, presently under development at FNAL and LBNL, with 90-mm aperture and gradient higher than 200 T/m. The design of the first LQ model will be completed by the end of 2007 with the selection of a mechanical design. In this paper we present the coil design addressing some fabrication technology issues, the quench protection study, and three designs of the support structure.
Date: June 1, 2008
Creator: Ambrosio, G.; Andreev, N.; Anerella, M.; Barzi, E.; Bossert, R.; Caspi, S. et al.
Partner: UNT Libraries Government Documents Department

The Pipe-Quadrupole, an Alternative for High Gradient Interaction Region Quadrupole Designs

Description: In the design of interaction region (IR) quadrupoles for high luminosity colliders such as the LHC or a possible upgrade of the Tevatron, the radiation heating of the coil windings is an important issue. Two obvious solutions to this problem can be chosen. The first is to reduce the heat load by added shielding, increased cooling with fins or using Nb{sub 3}Sn to increase the temperature margin. The second solution eliminates the conductor from the areas with the highest radiation intensity, which are located on the symmetry-axes of the midplanes of the coils. A novel quadrupole design is presented, in which the conductor is wound on four half-moon shaped supports, forming elongated toroid sections. The assembly of the four shapes yields a quadrupole field with an active flux return path, and a void in the high radiation area. This void can be occupied by a liquid helium cooling pipe to lower the temperature of the windings from the inside. The coil layout, harmonic optimization and mechanical design are shown, together with the calculated temperature rise for the radiation load of the LHC interaction region quadrupoles.
Date: December 12, 1996
Creator: Oort, J.M. van & Scanlan, R.M.
Partner: UNT Libraries Government Documents Department

The Role of Injury-related Injustice Perception in Adjustment to Spinal Cord Injury: an Exploratory Analysis

Description: Research has begun to explore the presence and role of health-related injustice perceptions in samples of individuals who experience chronic pain associated with traumatic injury. Existing studies indicate that higher level of injustice perception is associated with poorer physical and psychosocial outcomes. However, to date, few clinical populations have been addressed. The aim of the current study was to explore injustice perceptions in a sample of individuals who have sustained a spinal cord injury (SCI), as research suggests that such individuals are likely to experience cognitive elements characteristic of injustice perception (e.g., perceptions of irreparable loss, blame, and unfairness). The study explored the relationship between participants’ level of perceived injustice and several variables associated with outcomes following SCI (depression, pain, and disability) at initial admission to a rehabilitation unit and at three months following discharge. The Injustice Experience Questionnaire was used to measure injustice perceptions. IEQ was found to significantly contribute to depression and anger at baseline. IEQ significantly contributed to depression, present pain intensity, and anger at follow-up. The implication of these preliminary findings may be beneficial for development of future interventions, as many individuals in the United States experience the lifelong physical and psychological consequences of SCI at a high personal and public cost.
Date: December 2015
Creator: Garner, Ashley Nicole
Partner: UNT Libraries

Medical Applications of Space Light-Emitting Diode Technology--Space Station and Beyond

Description: Space light-emitting diode (LED) technology has provided medicine with a new tool capable of delivering light deep into tissues of the body, at wavelengths which are biologically optimal for cancer treatment and wound healing. This LED technology has already flown on Space Shuttle missions, and shows promise for wound healing applications of benefit to Space Station astronauts.
Date: June 1, 1999
Creator: Whelan, H.T.; Houle, J.M.; Donohoe, D.L.; Bajic, D.M.; Schmidt, M.H.; Reichert, K.W. et al.
Partner: UNT Libraries Government Documents Department

Integrated Detection of Pathogens and Host Biomarkers for Wounds

Description: The increasing incidence and complications arising from combat wounds has necessitated a reassessment of methods for effective treatment. Infection, excessive inflammation, and incidence of drug-resistant organisms all contribute toward negative outcomes for afflicted individuals. The organisms and host processes involved in wound progression, however, are incompletely understood. We therefore set out, using our unique technical resources, to construct a profile of combat wounds which did or did not successfully resolve. We employed the Lawrence Livermore Microbial Detection Array and identified a number of nosocomial pathogens present in wound samples. Some of these identities corresponded with bacterial isolates previously cultured, while others were not obtained via standard microbiology. Further, we optimized proteomics protocols for the identification of host biomarkers indicative of various stages in wound progression. In combination with our pathogen data, our biomarker discovery efforts will provide a profile corresponding to wound complications, and will assist significantly in treatment of these complex cases.
Date: March 19, 2012
Creator: Jaing, C
Partner: UNT Libraries Government Documents Department

Head Trauma Release of Histamine from Dural Mast Cells Alters Blood-Brain Barrier: Attenuation with Zolantidine

Description: This study employed a new model of mild-to-moderate head trauma to specifically identify the role of dural mast cell (MC) histamine in trauma-induced increased permeability in the blood-brain barrier (BBB). A single line was scored partially through the left dorsal parietal skull. Immediately following the trauma, degranulation was seen in 39% of the MCs on the left and in 2% on the right. After a 20 min survival period, left duras showed 55% with MC degranulation (fewer with complete degranulation) compared to 34% on the right. In the other experiments two parallel lines were scored following the injection of Evan's blue. Histamine assay showed histamine increased in the left cortex to 154% at 5 min, 174% at 10 min, and 151% at 20 min. Fluorescent quantitation of extravasated Evan's blue at 20 min following the trauma gave an increase of 1385% over the value measured for the right cortex. Zolantidine, a selective histamine H2 receptor antagonist, administered at 10- and 20- mg/kg 30 min before the trauma blocked 65% of the Evan's blue extravasation compared with the control and 2.5 mg group.
Date: December 2000
Creator: Laufer, Susan R.
Partner: UNT Libraries

Burn Depth Estimation Based on Infrared Imaging of Thermally Excited Tissue

Description: Accurate estimation of the depth of partial-thickness burns and the early prediction of a need for surgical intervention are difficult. A non-invasive technique utilizing the difference in thermal relaxation time between burned and normal skin may be useful in this regard. In practice, a thermal camera would record the skin's response to heating or cooling by a small amount-roughly 5 C for a short duration. The thermal stimulus would be provided by a heat lamp, hot or cold air, or other means. Processing of the thermal transients would reveal areas that returned to equilibrium at different rates, which should correspond to different burn depths. In deeper thickness burns, the outside layer of skin is further removed from the constant-temperature region maintained through blood flow. Deeper thickness areas should thus return to equilibrium more slowly than other areas. Since the technique only records changes in the skin's temperature, it is not sensitive to room temperature, the burn's location, or the state of the patient. Preliminary results are presented for analysis of a simulated burn, formed by applying a patch of biosynthetic wound dressing on top of normal skin tissue.
Date: March 5, 1999
Creator: Dickey, F.M.; Hoswade, S.C. & Yee, M.L.
Partner: UNT Libraries Government Documents Department

High definition ultrasound imaging for battlefield medical applications

Description: A team has developed an improved resolution ultrasound system for low cost diagnostics. This paper describes the development of an ultrasound based imaging system capable of generating 3D images showing surface and subsurface tissue and bone structures. We include results of a comparative study between images obtained from X-Ray Computed Tomography (CT) and ultrasound. We found that the quality of ultrasound images compares favorably with those from CT. Volumetric and surface data extracted from these images were within 7% of the range between ultrasound and CT scans. We also include images of porcine abdominal scans from two different sets of animal trials.
Date: June 23, 1996
Creator: Kwok, K.S.; Morimoto, A.K.; Kozlowski, D.M.; Krumm, J.C.; Dickey, F.M.; Rogers, B et al.
Partner: UNT Libraries Government Documents Department

Megagauss Fields During Milliseconds

Description: A non-destructive, one megagauss magnet is now being designed in cooperation between Los Alamos and the National High Magnetic Field Laboratory (NHMFL) through joint funding by the US Department of Energy and the US NSF. The design combines two types of pulsed magnet now in use at the NHMFL: a capacitor-driven 'insert' magnet with a total pulse width of order 10 ms and a much larger 'outsert' magnet with a total pulse width of order 2 seconds that is driven by a controlled power source. The insert and outsert produce approximately 1/2 megagauss each. Although the design uses CuAg as the principal conductor further design efforts and materials development are exploring CuNb and stainless steel-clad copper as possible future alternatives. A crucial innovation was to employ wound steel strip (sheet) as a reinforcement in both insert and outsert coils. This gives extra strength due to the higher degree of cold-work possible in strip materials. For this leading edge magnet a key role is played by materials development. A major component, the 7 module 560 MVA controlled dc power supply required for the outsert, has been installed and commissioned.
Date: October 18, 1998
Creator: Campbell, L.J.; Embury, D.; Han, K.; Parkin, D.M.; Baca, A.; Kihara, K.H. et al.
Partner: UNT Libraries Government Documents Department

Nuclear Energy Research Initiative (NERI) Program Continuous Fiber Wound Ceramic Composite (CFCC) for Commercial Water Reactor Fuel-Technical Progress Report

Description: This project began on August 1, 1999. As of July 1, 2000, the progress has been in materials production, test planning, testing facility design & instruction, and calibration. One new subcontractor was added to provide a solution to the CFCC material permeability issue (Northwestern University). This is in addition to the three subcontracts that were previously in place (McDermott Technologies Inc. for continuous fiber reinforced ceramic tubing fabrication, Swales Aerospace for LOCA testing of tubes, and Massachusetts Institute of Technology for In Reactor testing of tubes).
Date: July 11, 2000
Partner: UNT Libraries Government Documents Department

Detection of Malingering on Raven's Standard Progressive Matrices and the Booklet Category Test

Description: The capacity of Raven's Standard Progressive Matrices (SPM) and the Booklet Category Test (BCT) to discriminate between groups of brain-injured, simulated malingering, and normal participants was investigated in this study. Exploratory analyses were also conducted to examine the differences between groups categorized as sophisticated and naive fakers. Clinical decision rules and discriminant function analyses were utilized to identify malingerers. Clinical decision rules ranged in hit rates from 41% to 78%, in sensitivity from 2% to 100%, and in specificity from 86% to 100%. Discriminant functions ranged in hit rates from 81% to 86%, in sensitivity from 68% to 73% and in specificity from 82% to 87%. Overall, the least helpful detection method examined was below chance responding on either measure, while the most efficient was gross errors for SPM.
Date: December 1997
Creator: Isler, William C. (William Charles)
Partner: UNT Libraries

In Vitro Studies of Nuclear Changes in Mammalian CNS Neurons Subjected to Rapid Acceleration Impact Injury

Description: An in vitro model of Rapid Acceleration Impact (RAI) Injury was used to study the effects of multiple impact (220 g/impact, 3-5 sec intervals) trauma on cultures of murine CNS cells. Investigations with spinal cord cultures showed that 1) multiple impacts delivered tangential to the plane of cell growth caused neuronal death (12% after 3 impacts to 46% after 10 impacts); 2) multiple impacts delivered normal to the plane of cell growth were much less effective (8% dead after 10 impacts); 3) most neuronal death occurred within 15 minutes after injury 4) morphological changes observed included increased nuclear prominence and somal swelling; and 5) pretreatment with ketamine (0.1mM) reduced cell death from 51 to 14% and reduced somal swelling. Identical studies performed on cortical cultures revealed minimal differences between the two tissues in their response to multiple tangential impacts.
Date: May 1995
Creator: Wolf, Amy
Partner: UNT Libraries

Bridge Grafting of Fruit Trees

Description: This report discusses bridge grafting, which is a method for treating wounds on fruit trees inflicted by mice and rabbits. Instruction for successful bridge grafting are included.
Date: 1916
Creator: Fletcher, W. F.
Partner: UNT Libraries Government Documents Department

Neuronal Survival After Dendrite Amputation: Investigation of Injury Current Blockage

Description: After dendrite transection, two primary injury current pathways may acount for cell death: (1) the lesion current at the site of injury and (2) the voltage sensitive calcium channels along the dendrite. Lesions were made with a laser microbeam in mouse spinal monolayer cell cultures. Polylysine was tried as a positively charged "molecular bandage" to block the lesion current. The calcium channel blockers, verapamil and nifedipine, were used to reduce the calcium channel current. Control toxicity curves were obtained for all three compounds. The results show that neither verapamil, nifedipine, nor polylysine (MW: 3,300) protect nerve cells after dendrite amputation 100 ptm from the soma. The data also indicate that these compounds do not slow the process of cell death after such physical trauma.
Date: December 1988
Creator: Shi, Ri Yi
Partner: UNT Libraries

The Mechanical and Thermal Design for the MICE Focusing SolenoidMagnet System

Description: The focusing solenoids for MICE surround energy absorbers that are used to reduce the transverse momentum of the muon beam that is being cooled within MICE. The focusing solenoids will have a warm-bore diameter of 470 mm. Within this bore is a flask of liquid hydrogen or a room temperature beryllium absorber. The focusing solenoid consists of two coils wound with a copper matrix Nb-Ti conductor originally designed for MRI magnets. The two coils have separate leads, so that they may be operated at the same polarity or at opposite polarity. The focusing magnet is designed so that it can be cooled with a pair of 1.5 W (at 4.2 K) coolers. The MICE cooling channel has three focusing magnets with their absorbers. The three focusing magnets will be hooked together in series for a circuit stored-energy of about 9.0 MJ. Quench protection for the focusing magnets is discussed. This report presents the mechanical and thermal design parameters for this magnet, including the results of finite element calculations of mechanical forces and heat flow in the magnet cold mass.
Date: May 7, 2004
Creator: Yang, S.Q.; Green, M.A.; Barr, G.; Bravar, U.; Cobb, J.; Lau, W. et al.
Partner: UNT Libraries Government Documents Department