Smad3 recruits the anaphase-promoting complex for ubiquitination and degradation of SnoN
Description:
Smad proteins mediate transforming growth factor-b signaling to regulate cell growth and differentiation. SnoN is an important negative regulator of TGFb signaling that functions to maintain the repressed state of TGFb target genes in the absence of ligand. Upon TGFb stimulation, Smad3 and Smad2 translocate into the nucleus and induce a rapid degradation of SnoN, allowing activation of TGFb target genes. Here we show that Smad2- or Smad3-induced degradation of SnoN requires the ubiquitin-depend…
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Date:
September 11, 2001
Creator:
Stroschein, Shannon L.; Bonni, Shirin; Wrana, Jeffrey L. & Luo, Kunxin
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UNT Libraries Government Documents Department