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The Mechanism of Genetic Effect of P32 in Bacteria

Description: The biological effect of absorbed unstable isotopes is related, in some cases, to the chemical changes resulting from radioactive decay rather than to the accompanying radiations. The special geometric and metabolic characteristics of bacterial cultures are employed to show that genetic effects of P32 may be attributable to the rupture of the phosphate band in deoxyribose nucleic acid. Other examples to illustrate the use of the nuclear disintegration technique an an indicator of the specific c… more
Date: unknown
Creator: Rubin, B. A.
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
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Insulin and the Relation Between Phosphate Transport and Glucose Metabolism

Description: The experiments to be described were undertaken to correlate the metabolism of glucose by muscle with the transport of phosphate across the cell membrane, and the relative effects of insulin on the two processes. The isolated rat diaphragm was used as the experimental tissue, and P-32 phosphate and glucose uniformly labeled with C-14 were used as tracers. The selection of diaphragm was based on the finding first made by Gemmill (1) that the addition of the insulin to an incubation medium contai… more
Date: unknown
Creator: Sacks, Jacob & Sinex, F., Marott
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
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The control of polycythemia by marrow inhibition

Description: Experimental use of sodium radiophosphate (P32)in treatment of polycythemia is described. Treatment history is 66 patients treated with P32 alone, 32 patients treated with P32 followed within 4 months by venesections, 21 patients treated with P32 followed more than 4 months later by venesections, 6 patients treated exclusively by venesections, and 9 patients treated and followed elsewhere.
Date: August 9, 1949
Creator: Lawrence, J.H.
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
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Human radiation studies: Remembering the early years. Oral history of Donner Lab Administrator Baird G. Whaley, August 15, 1994

Description: Baird G. Whaley, Donner Lab Administrator, was interviewed by representatives of US DOE Office of Human Radiation Experiments (OHRE). The purpose of the interview was to capture the remembrances of Mr. Whaley concerning what he could relate on activities at the Donner Lab that pertain to the OHRE responsibilities. Following a brief biographical sketch, Mr. Whaley relates his experiences in administration at the LAB including funding activities, staffing concerns, intralaboraory politics, and re… more
Date: September 1, 1995
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
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Behavior of Institutional Incinerators When Used to Burn Radioactive Wastes: Final Project Report for August 1, 1950-November 1, 1952

Description: This report deals with the development of methods and techniques for measuring the amounts of radioisotope on the stack wall, in ash, stack gas and atmosphere during and after incineration in the conventional refuse-type destructor.
Date: November 1, 1952
Creator: Kruse, C. W.; Freese, P. V.; Machis, A. & Behn, V. C.
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
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Human radiation studies: Remembering the early years. Oral history of Dr. Nadine Foreman, M.D., August 19, 1994

Description: Dr. Nadine Foreman was interviewed by representatives of the US DOE Office of Human Radiation Experiments (OHRE). Dr. Foreman was selected for interview because of the position she held at the University of California, San Francisco. Following a brief biographical sketch, Dr. Foreman describes her work with Dr. Mayo Soley using I-131 in treatment of hyperthyroidism, selection criteria for patients in the radioiodine project, work with Dr. Earl Miller, work at Highland Hospital, radioiodine trea… more
Date: July 1, 1995
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
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Ingestion of phosphorus-32 at Massachusetts Institute of Technology, Cambridge, Massachusetts, identified on August 19, 1995

Description: On Monday, October 16, 1995, the Massachussetts Institue of Technology (MIT, the licensee) notified the US Nuclear Regulatory Commission (NRC) of an incident involving ingestion of phosphorus-32 by a researcher at the MIT Center for Cancer Research. The licensee informed the NRC that a researcher had reported the incident on August 19. The licensee initially estimated the intake as 500 microcuries (19 MBq) and the dose as 4000 millirem (40 mSv) to the individual. On October 12, the licensee inf… more
Date: December 1, 1995
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
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Robust detailed mapping of the human genome

Description: The project aimed to develop a procedure for mapping genomic sequences based on principles and markers different from those invoked in conventional restriction site-based mapping. The primary markers are to be regions of about 50 to 300bp with thermal stability (the temperature required for disordering of the helix) that is significantly lower than the stability of the adjacent segments and also regions of particularly high thermal stability. Sequence-tagged-sites and other segments of known se… more
Date: December 31, 1992
Creator: Lerman, L. S.
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
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[Cloning-idependent mapping technology for genomic fidelity, contig linking, C-DNA site analysis, and gene detection]. Final report

Description: The project was designed to develop and apply a novel unconventional approach to genome mapping based on physical properties of DNA that are a sensitive function of the base sequence, and so does not depend on the clonability of the sequences to be mapped nor on the presence of particular restriction sites. We have shown that a broad array of DNA fragments are retarded at nearly the same level in denaturing gradient gel electrophoresis (DGGE) if the segment with the lowest thermal stability has… more
Date: December 25, 1994
Creator: Lerman, L. S.
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
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Fast Neutron Flux Measurements for Shielding Applications

Description: Pressed sulfur pellets, irradiated for two hours at 10 w yielded satisfactory counting rates on an internal proportional counter for measuring fast neutrons. The pellets were counted in their original form and an equation applicable to thick sources was applied to obtain disintegration rates. Decay data and beta energy analyses indicated that the induced activity was due to P/ sup 32/. Cross section values reported in the literature for the S/sup 32/(n,p)P/ sup 32/ reaction involved were found … more
Date: August 27, 1959
Creator: Roy, M.
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
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Age estimates of stratospheric air

Description: It is shown that careful consideration of /sup 32/P//sup 7/Be ratios (both isotopes being generated in the atmosphere by cosmic radiation) not only yields information on the stratospheric or tropospheric origin of air masses. These ratios may also be used to determine the residence time in the stratosphere of tropospheric air that underwent upward transport through the tropopause and re-entered the troposphere at a later date. (auth)
Date: August 1973
Creator: Reiter, Elmar R.
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
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Biomedical Radioisotope Program. Progress report for quarter ending March 31, 1977

Description: Progress is reported for the applications of {sup 11}C, {sup 195m}Pt, and {sup 123m}Te. Of note in this report period is the presentation of images of rat adrenals with a {sup 123m}Te-labeled steriod and an investigation of steriod structural parameters which affect adrenal concentration. Two new {sup 195m}Pt-labeled compounds have been prepared for evaluation as chemotherapeutic agents.
Date: June 1, 1977
Creator: Poggenburg, J.K.
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
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Studies of the hemolytic effect of radiation

Description: These studies were aimed at elucidating affects of radiation in inducing hemolysis independent of inhibition of erythropoiesis. Research studies were conducted both on human patients and dogs. Phosphorus-32 in mc amounts were administered either intravenously or orally to patients suffering Polycythemia rubra vera. Dogs were treated with either P-32 or x-radiation. Hemoglobin metabolism was monitored in all test subjects by hematology, blood chemistry, and fecal excretion of hemoglobin cataboli… more
Date: July 10, 1945
Creator: Schwartz, S.; Katz, E.; Porter, L.M.; Jacobson, L.O. & Watson, C.J.
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
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Mechanisms of radiation-induced gene responses

Description: In the process of identifying genes differentially expressed in cells exposed ultraviolet radiation, we have identified a transcript having a 26-bp region that is highly conserved in a variety of species including Bacillus circulans, yeast, pumpkin, Drosophila, mouse, and man. When the 5` region (flanking region or UTR) of a gene, the sequence is predominantly in +/+ orientation with respect to the coding DNA strand; while in the coding region and the 3` region (UTR), the sequence is most frequ… more
Date: October 1996
Creator: Woloschak, G. E. & Paunesku, T.
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
open access

SMALL-ORDER SHAPE FACTORS IN In$sup 114$, P$sup 32$, AND Y$sup 9$$sup 0$

Description: The beta spectra of In/sup 114/, P/sup 32/, and Y/sup 90/ were stud ied closely in an intermediate-image beta-ray spectrometer and compared to theoretical predictions in terms of a linear shape factor of the form (1 + aW). The values obtained for a were s for P/sup 32/, and (-0.0047 plus or minus 0.0008)/mc/sup 2/ for Y/sup 90/, all for electron kinetic energies from about 200 kev up to near the maximum beta energies. Tests were made to give indications for spectrometer fidelity. Because of the… more
Date: April 1, 1961
Creator: Nichols, R. T.; McAdams, R. E. & Jensen, E. N.
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
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Mechanism and structure of the plant plasma membrane Ca{sup 2+}-ATPase

Description: Objectives of this project were the following: development of an enriched preparation of the red beet plasma membrane Ca{sup 2+} ATPase in order to develop a procedure for detergent solubilization of the enzyme from the membrane using detergents, resolution by a method which could be upscaled for batch isolation, and then reconstitution into liposomes to allow characterization of Ca{sup 2+} transport by the purified enzyme and; characterization of the reaction mechanism for the coupling of nucl… more
Date: December 31, 1993
Creator: Briskin, D. P.
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
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