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Identification of Novel Cell Wall Components

Description: Our DOE Biosciences-funded work focused on the fungal cell wall and morphogenesis. We are especially interested in how new cell wall material is targeted to appropriate areas for polar (asymmetric) growth. Polar growth is the only way that filamentous fungi explore the environment to find suitable substrates to degrade. Work funded by this grant has resulted in a total of twenty peer-reviewed publications. In work funded by this grant, we identified nine Aspergillus nidulans temperature-sensiti… more
Date: October 26, 2009
Creator: Momany, Michelle
Item Type: Refine your search to only Report
Partner: UNT Libraries Government Documents Department
open access

A NON-CLEAVABLE UmuD VARIANT THAT ACTS AS A UmuD' MIMIC

Description: UmuD{sub 2} cleaves and removes its N-terminal 24 amino acids to form UmuD'{sub 2}, which activates UmuC for its role in UV-induced mutagenesis in E. coli. Cells with a non-cleavable UmuD exhibit essentially no UV-induced mutagenesis and are hypersensitive to killing by UV light. UmuD has been shown to bind to the beta processivity clamp (''beta'') of the replicative DNA polymerase, pol III. A possible beta-binding motif has been predicted in the same region of UmuD shown to be important for it… more
Date: October 26, 2005
Creator: Beuning, P J; Simon, S M; Zemla, A; Barsky, D & Walker, G C
Item Type: Refine your search to only Article
Partner: UNT Libraries Government Documents Department
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