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The use of the bio-photometer in determining the dark adaptation of pre-school age children

Description: The degree to which the normal eye can adapt to the dark is related to or dependent upon the eye's ability to regenerate visual purple. The relationship of vitamin A to the visual cycle has caused much development in improved methods of detecting vitamin A deficiency. For the most part these methods have been applied to adults and school age children. This study seeks to analyze this method as applied to pre-school age children.
Date: August 1941
Creator: Wright, Mary Lou McCauley
Partner: UNT Libraries

Pandemic Influenza Pediatric Office Plan Template

Description: This is a planning tool developed by pediatric stakeholders that is intended to assist pediatric medical offices that have no pandemic influenza plan in place, but may experience an increase in patient calls/visits or workload due to pandemic influenza.
Date: January 1, 2010
Creator: CHE, HCTT
Partner: UNT Libraries Government Documents Department

RBC-coupled tPA prevents cerebrovasodilatory impairment and tissue injury in pediatric cerebral hypoxia/ischemia through inhibition of ERK MAPK unregulation

Description: Babies experience hypoxia (H) and ischemia (I) from stroke. The only approved treatment for stroke is fibrinolytic therapy with tissue-type plasminogen activator (tPA). However, tPA potentiates H/I-induced impairment of responses to cerebrovasodilators such as hypercapnia and hypotension, and blockade of tPA-mediated vasoactivity prevents this deleterious effect. Coupling tPA to RBCs reduces its CNS toxicity through spatially confining the drug to the vasculature. Mitogen activated protein kinase (MAPK), a family of at least 3 kinases, is upregulated after H/I. In this study we determined if RBC-tPA given before or after cerebral H/I would preserve responses to cerebrovasodilators and prevent neuronal injury mediated through the ERK MAPK pathway. Animals given RBC-tPA maintained responses to cerebrovasodilators at levels equivalent to pre-H/I values. CSF and brain parenchymal ERK MAPK was elevated by H/I and this upregulation was potentiated by tPA, but blunted by RBC-tPA. U 0126, an ERK MAPK antagonist, also maintained cerebrovasodilation post H/I. Neuronal degeneration in CA1 hippocampus and parietal cortex after H/I was exacerbated by tPA, but ameliorated by RBC-tPA and U 0126. These data suggest that coupling tPA to RBCs may offer a novel approach towards increasing the benefit/risk ratio of thrombolytic therapy for CNS disorders associated with H/I.
Date: January 1, 2008
Creator: Ganguly, Kumkum; Armstead, William M; Kiessling, J W; Chen, Xiao - Han; Smith, Douglas H; Higazi, Abd Ar et al.
Partner: UNT Libraries Government Documents Department

MicroCT-Based Skeletal Models for Use in Tomographic Voxel Phantoms for Radiological Protection

Description: ABSTRACT The University of Florida (UF) proposes to develop two high-resolution image-based skeletal dosimetry models for direct use by ICRP Committee 2’s Task Group on Dose Calculation in their forthcoming Reference Voxel Male (RVM) and Reference Voxel Female (RVF) whole-body dosimetry phantoms. These two phantoms are CT-based, and thus do not have the image resolution to delineate and perform radiation transport modeling of the individual marrow cavities and bone trabeculae throughout their skeletal structures. Furthermore, new and innovative 3D microimaging techniques will now be required for the skeletal tissues following Committee 2’s revision of the target tissues of relevance for radiogenic bone cancer induction. This target tissue had been defined in ICRP Publication 30 as a 10-m cell layer on all bone surfaces of trabecular and cortical bone. The revised target tissue is now a 50-m layer within the marrow cavities of trabecular bone only and is exclusive of the marrow adipocytes. Clearly, this new definition requires the use of 3D microimages of the trabecular architecture not available from past 2D optical studies of the adult skeleton. With our recent acquisition of two relatively young cadavers (males of age 18-years and 40-years), we will develop a series of reference skeletal models that can be directly applied to (1) the new ICRP reference voxel man and female phantoms developed for the ICRP, and (2) pediatric phantoms developed to target the ICRP reference children. Dosimetry data to be developed will include absorbed fractions for internal beta and alpha-particle sources, as well as photon and neutron fluence-to-dose response functions for direct use in external dosimetry studies of the ICRP reference workers and members of the general public
Date: March 30, 2010
Creator: Bolch, Wesley
Partner: UNT Libraries Government Documents Department

Scientific/Technical Report Bioenergetics Research Initiative Award number-DE-FG02-05ER64092

Description: General Project Overview and Final Technical Report This equipment grant was utilized to enhance the infrastructure of the Human Performance Laboratory at Ball State University. The laboratories primary focus is human based exercise physiology conducting research in the areas of sports performance, aging and exercise, unloading (space flight and bed rest), pediatric exercise and clinical exercise physiology. The main equipment supported by this grant was an ultrasound unit for cardiac and skeletal muscle imaging at the whole organ level, microscope system for micro imaging of skeletal muscle tissue, running treadmill for energy expenditure assessment, autoclave for sterilization, and upgrade to our dual x‐ray absorptiometry (DEXA) system that was utilized for body composition measurements. The equipment was involved in several human metabolic and skeletal muscle research projects as highlighted above. In particular, this equipment served a support role for other large‐scale clinical projects funded by the National Institutes of Health (NIH), National Aeronautics and Space Administration (NASA), and corporate sponsors.
Date: December 4, 2009
Creator: Trappe, Scott A.
Partner: UNT Libraries Government Documents Department

[News Clip: Infant swimming]

Description: B-roll footage from the NBC 5 television station in Fort Worth, Texas, to accompany a news story about swimming lessons for infants. This story aired at 5 P.M.
Date: June 29, 2009, 5:00 p.m.
Creator: KXAS-TV (Television station : Fort Worth, Tex.)
Partner: UNT Libraries Special Collections

[News Clip: Liver transplant]

Description: Video footage from the KXAS-TV/NBC station in Fort Worth, Texas, covering a news story by reporter Larry Mullins about a mother who will be able to donate her liver to potentially save her daughter's life. This story aired at 6pm.
Date: unknown
Creator: KXAS-TV (Television station : Fort Worth, Tex.)
Location Info:
Partner: UNT Libraries Special Collections

Pediatric nuclear medicine

Description: This symposium presented the latest techniques and approaches to the proper medical application of radionuclides in pediatrics. An expert faculty, comprised of specialists in the field of pediatric nuclear medicine, discussed the major indications as well as the advantages and potential hazards of nuclear medicine procedures compared to other diagnostic modalities. In recent years, newer radiopharmaceuticals labeled with technetium-99m and other short-lived radionuclides with relatively favorable radiation characteristics have permitted a variety of diagnostic studies that are very useful clinically and carry a substantially lower radiation burden then many comparable X-ray studies. This new battery of nuclear medicine procedures is now widely available for diagnosis and management of pediatric patients. Many recent research studies in children have yielded data concerning the effacacy of these procedures, and current recommendations will be presented by those involved in conducting such studies. Individual papers are processed separately for the Energy Data Base.
Date: January 1, 1986
Partner: UNT Libraries Government Documents Department

Evaluation of the distribution of absorbed dose in child phantoms exposed to diagnostic medical x rays

Description: The purpose of this study was to determine, by theoretical calculation and experimental measurement, the absorbed dose distributions in two heterogeneous phantoms representing one-year- and five-year-old children from typical radiographic examinations for those ages. Theoretical work included the modification of an existing internal dose code which uses Monte Carlo methods to determine doses within the Snyder-Fisher mathematical phantom. A Ge(Li) detector and a pinhole collimator were used to measure x-ray spectra which served as input to the modified Monte Carlo codes which were used to calculate organ doses in children. The calculated and measured tissue-air values were compared for a number of organs. For most organs, the results of the calculated absorbed doses agreed with the measured absorbed doses within twice the coefficient of variation of the calculated value. The absorbed dose to specific organs for several selected radiological examinations are given for one-year-old, five-year-old, and adult phantoms.
Date: April 1, 1978
Creator: Chen, W. L.; Poston, J. W. & Warner, G. G.
Partner: UNT Libraries Government Documents Department

Development of mathematical pediatric phantoms for internal dose calculations: designs, limitations, and prospects

Description: Mathematical phantoms of the human body at various ages are employed with Monte Carlo radiation transport codes for calculation of photon specific absorbed fractions. The author has developed a pediatric phantom series based on the design of the adult phantom, but with explicit equations for each organ so that organ sizes and marrow distributions could be assigned properly. Since the phantoms comprise simple geometric shapes, predictive dose capability is limited when geometry is critical to the calculation. Hence, there is a demand for better phantom design in situations where geometry is critical, such as for external irradiation or for internal emitters with low energy photons. Recent advances in computerized axial tomography (CAT) present the potential for derivation of anatomical information, which is so critical to development of phantoms, and ongoing developmental work on compuer architecture to handle large arrays for Monte Carlo calculations should make complex-geometry dose calculations economically feasible within this decade.
Date: January 1, 1980
Creator: Cristy, M.
Partner: UNT Libraries Government Documents Department