Signaling to the P53 Tumor Suppressor Through Pathways Activated by Genotoxic and Non-Genotoxic Stresses.
Description:
The p53 tumor suppressor is a tetrameric transcription factor that is post-translational modified at {approx}18 different sites by phosphorylation, acetylation, or sumoylation in response to various cellular stress conditions. Specific posttranslational modifications, or groups of modifications, that result from the activation of different stress-induced signaling pathways are thought to modulate p53 activity to regulate cell fate by inducing cell cycle arrest, apoptosis, or cellular senescence…
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Date:
July 1, 2002
Creator:
Anderson, C. W. & Appella, E.
Item Type:
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UNT Libraries Government Documents Department