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ANXA1 inhibits miRNA-196a in a negative feedback loop through NF-kB and c-Myc to reduce breast cancer proliferation

Description: This article shows that miR196a was highly expressed in ER+MCF-7 breast cancer cells when compared to normal mammary gland cells, with expression levels negatively correlating to ANXA1.
Date: April 20, 2016
Creator: Yuan, Yi; Anbalagan, Durkeshwari; Lee, Lay Hoon; Samy, Ramar Perumal; Shanmugam, Muthu K.; Kumar, Alan Prem et al.
Partner: UNT College of Arts and Sciences

Idaho National Laboratory Experimental Program to Measure the Flow Phenomena in a Scaled Model of a Prismatic Gas-Cooled Reactor Lower Plenum for Validation of CFD Codes

Description: The experimental program that is being conducted at the Matched Index-of-Refraction (MIR) Flow Facility at Idaho National Laboratory (INL) to obtain benchmark data on measurements of flow phenomena in a scaled model of a prismatic gas-cooled reactor lower plenum using 3-D Particle Image Velocimetry (PIV) is presented. A description of the scaling analysis, experimental facility, 3-D PIV system, measurement uncertainties and analysis, experimental procedures and samples of the data sets that have been obtained are included. Samples of the data set that will be presented include mean-velocity-field and turbulence data in an approximately 1:7 scale model of a region of the lower plenum of a typical prismatic gas-cooled reactor (GCR) similar to a General Atomics Gas-Turbine-Modular Helium Reactor (GTMHR) design. This experiment has been selected as the first Standard Problem endorsed by the Generation IV International Forum. The flow in the lower plenum consists of multiple jets injected into a confined cross flow - with obstructions. The model consists of a row of full circular posts along its centerline with half-posts on the two parallel walls to approximate flow scaled to that expected from the staggered parallel rows of posts in the reactor design. The model is fabricated from clear, fused quartz to match the refractive-index of the mineral oil working fluid. The benefit of the MIR technique is that it permits high-quality measurements to be obtained without locating intrusive transducers that disturb the flow field and without distortion of the optical paths. An advantage of the INL MIR system is its large size which allows improved spatial and temporal resolution compared to similar facilities at smaller scales. Results concentrate on the region of the lower plenum near its far reflector wall (away from the outlet duct). Inlet jet Reynolds numbers (based on the jet diameter and the time-mean average ...
Date: September 1, 2008
Creator: Jr., Hugh M. McIlroy; McEligot, Donald M. & Pink, Robert J.
Partner: UNT Libraries Government Documents Department

IDAHO NATIONAL LABORATORY PROGRAM TO OBTAIN BENCHMARK DATA ON THE FLOW PHENOMENA IN A SCALED MODEL OF A PRISMATIC GAS-COOLED REACTOR LOWER PLENUM FOR THE VALIDATION OF CFD CODES

Description: The experimental program that is being conducted at the Matched Index-of-Refraction (MIR) Flow Facility at Idaho National Laboratory (INL) to obtain benchmark data on measurements of flow phenomena in a scaled model of a typical prismatic gas-cooled (GCR) reactor lower plenum using 3-D Particle Image Velocimetry (PIV) is presented. A detailed description of the model, scaling, the experimental facility, 3-D PIV system, measurement uncertainties and analysis, experimental procedures and samples of the data sets that have been obtained are included. Samples of the data set that are presented include mean-velocity-field and turbulence data in an approximately 1:7 scale model of a region of the lower plenum of a typical prismatic GCR design. This experiment has been selected as the first Standard Problem endorsed by the Generation IV International Forum. Results concentrate on the region of the lower plenum near its far reflector wall (away from the outlet duct). Inlet jet Reynolds numbers (based on the jet diameter and the time-mean average flow rate) are approximately 4,300 and 12,400. The measurements reveal undeveloped, non-uniform flow in the inlet jets and complicated flow patterns in the model lower plenum. Data include three-dimensional vector plots, data displays along the coordinate planes (slices) and charts that describe the component flows at specific regions in the model. Information on inlet flow is also presented.
Date: September 1, 2008
Creator: Jr., Hugh M. McIlroy; McEligot, Donald M. & Pink, Robert J.
Partner: UNT Libraries Government Documents Department

Particle Image Velocimetry Measurements and Analysis of Bypass Data for a Scaled 6mm Gap

Description: The purpose of the fluid dynamics experiments in the MIR (Matched Index of-Refraction) flow system at Idaho National Laboratory (INL) is to develop benchmark databases for the assessment of Computational Fluid Dynamics (CFD) solutions of the momentum equations, scalar mixing, and turbulence models for the flow ratios between coolant channels and bypass gaps in the interstitial regions of typical prismatic standard fuel element (SFE) or upper reflector block geometries of typical Modular High-temperature Gas-cooled Reactors (MHTGR) in the limiting case of negligible buoyancy and constant fluid properties. The experiments will use optical techniques, primarily particle image velocimetry (PIV) in the INL Matched Index of Refraction (MIR) flow system.
Date: September 1, 2012
Creator: Wolf, J.R.; Conder, T.E. & Schultz, R.R.
Partner: UNT Libraries Government Documents Department

Fundamental Studies of Copper Corrosion in Interconnect Fabrication Process and Spectroscopic Investigation of Low-k Structures

Description: In the first part of this dissertation, copper bimetallic corrosion and its inhibition in cleaning processes involved in interconnect fabrication is explored. In microelectronics fabrication, post chemical mechanical polishing (CMP) cleaning is required to remove organic contaminants and particles left on copper interconnects after the CMP process. Use of cleaning solutions, however, causes serious reliability issues due to corrosion and recession of the interconnects. In this study, different azole compounds are explored and pyrazole is found out to be a potentially superior Cu corrosion inhibitor, compared to the most widely used benzotriazole (BTA), for tetramethyl ammonium hydroxide (TMAH)-based post CMP cleaning solutions at pH 14. Micropattern corrosion screening results and electrochemical impedance spectroscopy (EIS) revealed that 1 mM Pyrazole in 8 wt% TMAH solution inhibits Cu corrosion more effectively than 10 mM benzotriazole (BTA) under same conditions. Moreover, water contact angle measurement results also showed that Pyrazole-treated Cu surfaces are relatively hydrophilic compared to those treated with BTA/TMAH. X-ray photoelectron spectroscopy (XPS) analysis supports Cu-Pyrazole complex formation on the Cu surface. Overall Cu corrosion rate in TMAH-based highly alkaline post CMP cleaning solution is shown to be considerably reduced to less than 1Å/min by addition of 1 mM Pyrazole. In the second part, a novel technique built in-house called multiple internal Reflection Infrared Spectroscopy (MIR-IR) was explored as a characterization tool for characterization of different low-k structures.In leading edge integrated circuit manufacturing, reduction of RC time delay by incorporation of porous ultra low-k interlayer dielectrics into Cu interconnect nanostructure continues to pose major integration challenges. The main challenge is that porous structure renders interlayer dielectrics mechanically weak, chemically unstable and more susceptible to the RIE plasma etching damages. Besides the challenge of handling weak porous ultra low-k materials, a lack of sensitive metrology to guide systematic development of plasma etching, ...
Date: December 2015
Creator: Goswami, Arindom
Partner: UNT Libraries

Applying lessons learned to enhance human performance and reduce human error for ISS operations

Description: A major component of reliability, safety, and mission success for space missions is ensuring that the humans involved (flight crew, ground crew, mission control, etc.) perform their tasks and functions as required. This includes compliance with training and procedures during normal conditions, and successful compensation when malfunctions or unexpected conditions occur. A very significant issue that affects human performance in space flight is human error. Human errors can invalidate carefully designed equipment and procedures. If certain errors combine with equipment failures or design flaws, mission failure or loss of life can occur. The control of human error during operation of the International Space Station (ISS) will be critical to the overall success of the program. As experience from Mir operations has shown, human performance plays a vital role in the success or failure of long duration space missions. The Department of Energy`s Idaho National Engineering and Environmental Laboratory (INEEL) is developed a systematic approach to enhance human performance and reduce human errors for ISS operations. This approach is based on the systematic identification and evaluation of lessons learned from past space missions such as Mir to enhance the design and operation of ISS. This paper describes previous INEEL research on human error sponsored by NASA and how it can be applied to enhance human reliability for ISS.
Date: September 1, 1998
Creator: Nelson, W.R.
Partner: UNT Libraries Government Documents Department

Large Matched-Index-of-Refraction (MIR) Flow Systems for International Collaboration In Fluid Mechanics

Description: In recent international collaboration, INL and Uni. Erlangen have developed large MIR flow systems which can be ideal for joint graduate student education and research. The benefit of the MIR technique is that it permits optical measurements to determine flow characteristics in complex passages and around objects to be obtained without locating a disturbing transducer in the flow field and without distortion of the optical paths. The MIR technique is not new itself; others employed it earlier. The innovation of these MIR systems is their large size relative to previous experiments, yielding improved spatial and temporal resolution. This report will discuss the benefits of the technique, characteristics of the systems and some examples of their applications to complex situations. Typically their experiments have provided new fundamental understanding plus benchmark data for assessment and possible validation of computational thermal fluid dynamic codes.
Date: July 1, 2010
Creator: McEligot, Donald M.; Becker, Stefan & Hugh M. McIlroy, Jr.
Partner: UNT Libraries Government Documents Department

A multi-dimensional entropy model of jazz improvisation for music information retrieval.

Description: Jazz improvisation provides a case context for examining information in music; entropy provides a means for representing music for retrieval. Entropy measures are shown to distinguish between different improvisations on the same theme, thus demonstrating their potential for representing jazz information for analysis and retrieval. The calculated entropy measures are calibrated against human representation by means of a case study of an advanced jazz improvisation course, in which synonyms for "entropy" are frequently used by the instructor. The data sets are examined for insights in music information retrieval, music information behavior, and music representation.
Date: December 2005
Creator: Simon, Scott J.
Partner: UNT Libraries

[News Clip: Mir Problems]

Description: Video footage from the KXAS-TV/NBC station in Fort Worth, Texas, to accompany a news story. This story aired at 10:00 P.M.
Date: August 25, 1997
Creator: KXAS-TV (Television station : Fort Worth, Tex.)
Partner: UNT Libraries Special Collections

Interfacial Electrochemistry of Cu/Al Alloys for IC Packaging and Chemical Bonding Characterization of Boron Doped Hydrogenated Amorphous Silicon Films for Infrared Cameras

Description: We focused on a non-cooling room temperature microbolometer infrared imaging array device which includes a sensing layer of p-type a-Si:H component layers doped with boron. Boron incorporation and bonding configuration were investigated for a-Si:H films grown by plasma enhanced chemical deposition (PECVD) at varying substrate temperatures, hydrogen dilution of the silane precursor, and dopant to silane ratio using multiple internal reflection infrared spectroscopy (MIR-IR). This study was then confirmed from collaborators via Raman spectroscopy. MIR-IR analyses reveal an interesting counter-balance relationship between boron-doping and hydrogen-dilution growth parameters in PECVD-grown a-Si:H. Specifically, an increase in the hydrogen dilution ratio (H2/SiH4) or substrate temperature was found to increase organization of the silicon lattice in the amorphous films. It resulted in the decrease of the most stable SiH bonding configuration and thus decrease the organization of the film. The new chemical bonding information of a-Si:H thin film was correlated with the various boron doping mechanisms proposed by theoretical calculations. The study revealed the corrosion morphology progression on aluminum alloy (Al, 0.5% Cu) under acidic chloride solution. This is due to defects and a higher copper content at the grain boundary. Direct galvanic current measurement, linear sweep voltammetry (LSV), and Tafel plots are used to measure corrosion current and potential. Hydrogen gas evolution was also observed (for the first time) in Cu/Al bimetallic interface in areas of active corrosion. Mechanistic insight that leads to effective prevention of aluminum bond pad corrosion is explored and discussed. (Chapter 4) Aluminum bond pad corrosion activity and mechanistic insight at a Cu/Al bimetallic interface typically used in microelectronic packages for automotive applications were investigated by means of optical and scanning electron microscopy (SEM), energy dispersive X-ray spectroscopy (EDX) and electrochemistry. Screening of corrosion variables (temperature, moisture, chloride ion concentration, pH) have been investigated to find their effect on ...
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Date: May 2016
Creator: Ross, Nick Mark
Partner: UNT Libraries

[News Clip: MIR]

Description: Video footage from the KXAS-TV/NBC station in Fort Worth, Texas, to accompany a news story. This story aired at 5:00 P.M.
Date: August 13, 1997
Creator: KXAS-TV (Television station : Fort Worth, Tex.)
Partner: UNT Libraries Special Collections